MF498 _Prostaglandin Receptor Antagonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMF498Cat. No.: HY-10794CAS No.: 915191-42-3分式: CHNOS分量: 603.69作靶點(diǎn): Prostaglandin Receptor作通路: GPCR/G Protein儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 31 mg/mL (51.35 mM)* means solubl

2、e, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.6565 mL 8.2824 mL 16.5648 mL5 mM 0.3313 mL 1.6565 mL 3.3130 mL10 mM 0.1656 mL 0.8282 mL 1.6565 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；

3、澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.14 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.14 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small

4、 Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (4.14 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 MF498種新型的選擇性前列腺素E4受體(EP4受體)拮抗劑，與EP4受體具有強(qiáng)親和, Ki 為0.7 nM。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) J Virol. 2018 Sep 26;92(20). pii: e01018-18.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Clark P, et al. MF4

5、98 N-4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo3,4-gquinolin-7-yl)-3-methylbenzylsulfonyl-2-(2-methoxyphenyl)acetamide, a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58