Mcl1-IN-2 _Bcl-2 Family 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMcl1-IN-2Cat. No.: HY-12826CAS No.: 292057-76-2分式: CHNOS分量: 333.41作靶點(diǎn): Bcl-2 Family作通路: Apoptosis儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 33.33 mg/mL (99.97 mM; Need ultrasonic)Mass

2、Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.9993 mL 14.9966 mL 29.9931 mL5 mM 0.5999 mL 2.9993 mL 5.9986 mL10 mM 0.2999 mL 1.4997 mL 2.9993 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分

3、指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.50 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.50 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Mcl1-IN-2種髓細(xì)胞因 1 (Mcl-1)

4、抑制劑。IC50 & Target Mcl-1體外研究 Mcl1-IN-2 (Compound 2) is a Mcl-1 inhibitor, though without a reported IC50 value 1.REFERENCES1. Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. BioorgMed Chem. 2013 Nov 1;21(21):6642-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: