STAT5-IN-1 - STAT 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESTAT5-IN-1Cat. No.: HY-101853CAS No.: 285986-31-4分式: CHNO分量: 293.28作靶點(diǎn): STAT作通路: JAK/STAT Signaling; Stem Cell/Wnt儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 20 mg/mL (68.19 mM; Need ul

2、trasonic)H2O : 90% corn oilSolubility: 2 mg/mL (6.82 mM); Precipitated solution; Need ultrasonicBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 STAT5-IN-1是STAT5 的抑制劑，對(duì) STAT5 亞型的 IC50 值為 47 M。IC50 & Target STAT547 M (IC50)體外研究 The signal transducer and activator of transcripti

3、on 5 (STAT5) is a member of the STAT family of proteins,implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. Thefunctions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent(IC50500 M). STAT5-IN-1 block

4、 STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of thehydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5,but leads to complete loss of selectivity against other STAT family members 1.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Nat Commun. 2018 Nov 19;9(1):4874

5、. Biomaterials. 2017 Jun;130:14-27. Front Immunol. 2018 Aug 13;9:1755. Biol Blood Marrow Transplant. 2019 Jun 10. pii: S1083-8791(19)30366-0. SSRN. 2019 Apr.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Mller J, et al. Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem. 2008 Mar 25;9(5):723-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;