Astragalin-Astragaline-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAstragalinCat. No.: HY-N0015CAS No.: 480-10-4Synonyms: Astragaline; 3-Glucosylkaempferol; Kaempferol 3-D-glucopyranoside分式: CHO分量: 448.38作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mont

2、h溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (223.03 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.2303 mL 11.1513 mL 22.3025 mL5 mM 0.4461 mL 2.2303 mL 4.4605 mL10 mM 0.2230 mL 1.1151 mL 2.2303 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福?/p>

3、配制前請(qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.58 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChe

4、mESolubility: 2.5 mg/mL (5.58 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.58 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 紫云英苷（奈酚-3-O-葡萄糖苷）種黃酮類化合物，具有抗炎活性。REFERENCES1. Cho IH, et al. Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modula

5、ting oxidative stress-responsiveMAPK signaling. BMC Pulm Med. 2014 Jul 29;14:122.2. Li F, et al. Inhibitory effects of astragalin on lipopolysaccharide-induced inflammatory response in mouse mammary epithelial cells. JSurg Res. 2014 Dec;192(2):573-81.3. Li F, et al. Astragalin suppresses inflammator

6、y responses via down-regulation of NF-B signaling pathway in lipopolysaccharide-inducedmastitis in a murine model. Int Immunopharmacol. 2013 Oct;17(2):478-82.4. Kim MS, et al. Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-B inmacrophage

7、s. Arch Pharm Res. 2011 Dec;34(12):2101-7.5. Soromou LW, et al. Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-B signalingpathway. Biochem Biophys Res Commun. 2012 Mar 9;419(2):256-61.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use