Sinefungin-Adenosyl-Ornithine-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESinefunginCat. No.: HY-101938CAS No.: 58944-73-3Synonyms: Adenosyl-Ornithine; A-9145; Antibiotic 32232RP分式: CHNO分量: 381.39作靶點(diǎn): Histone Methyltransferase作通路: Epigenetics儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -2

2、0C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 100 mg/mL (262.20 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.6220 mL 13.1099 mL 26.2199 mL5 mM 0.5244 mL 2.6220 mL 5.2440 mL10 mM 0.2622 mL 1.3110 mL 2.6220 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物

3、活性 Sinefungin是病毒mRNA (鳥嘌呤-7-)-甲基轉(zhuǎn)移酶、 mRNA (核苷-2-)-甲基轉(zhuǎn)移酶和病毒增殖的有效抑制劑。Sinefungin 種SET7/9 抑制劑，通過抑制 H3K4 甲基化來改善腎纖維化。REFERENCES1. Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2-)-methyltransferase,and viral multiplication. J Biol Chem. 1978 J

4、un 25;253(12):4075-7.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE2. Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016Jan;27(1):203-15.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-