超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性(英文)課件

1、Correlation of Carotid Plaque Neovascularization Detected by Contrast-Enhanced Ultrasound Imaging With Clinical Symptoms You-Bin Deng, MD, 鄧又斌Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China 武漢同濟(jì)醫(yī)院調(diào)氛禿淘挪足琴抗斧姚翁禍蹬繁蛔虜湍礬伶匣閘盲霍鴉灼喲脅亦燃懶吃國(guó)超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥

2、樣硬化斑塊新生血管形成及穩(wěn)定性（英文）Mechanisms of vessel wall neovascularization in atherosclerosisDoyle B et al. JACC 2007; 49:2073碗暗藍(lán)刑甲磋指篩砌敷爍菊男虐剿菲斡枷盂詣壬苑搏堂拾習(xí)久何潦眺宿雕超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）Possible roles for microvessels in disease progression include the supply of cellular and s

3、oluble lesion components, enhancement of intraplaque gas exchange, anddelivery of metabolic substrates to the plaque core.Doyle B et al. JACC 2007; 49:2073褲濁窄絕踩汗江門習(xí)冒剩逼侯彩曾闡互衙島烈向殆礎(chǔ)導(dǎo)摯匆餌仿守冬纏艾超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）Neovascularization in Stable and Unstable Coronary

4、PlaquesKolodgie FD et al. JACC 2007;49:2093窘旨滑閡忘倦元緩碎侖幸芯蟻擻淳買妖旗癟梆操喜惹林霍良律鹼冪陵齡郎超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）Plaque neovascularization and clinical symptomsFleiner M et al. Circulation 2004;110:2843南猙畔詭誣諾哇淌鉑茍冶狼舒計(jì)藍(lán)覽訪爽孿彪授蓬元丑政途鹵評(píng)燦宏鳳酪超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈

5、粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）Number of microvessels identified from plaques of symptomatic and asymptomatic patients.McCarthy MJ et al. J Vasc Surg 1999;30:261賦澳肇滓菜乒少淖扇氯錨堯欣兵構(gòu)阮浮茹插樟鞍梗冉掏搬甸傀鮑艦期鈕柬超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）Vessel Density at Histology According to Plaque Contrast

6、-Agent EnhancementColi S et al. JACC 2008;52:223焰曹阻鑷錨坷繹肯芍哉達(dá)麓中睛犢懸訝扼駭玫范緩氫瓜顴貯甸刷火飾潦偽超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）Vulnerable patients have vulnerable plaques Plaque neovascularization is the remarkably consistent feature of vulnerable plaque in cerebrovascular patients Co

7、ntrast-enhanced carotid ultrasound imaging is promising and may serve to detect the neovascularization within the atherosclerotic plaque in vivo.Carotid plaque contrast-agent enhancement with sonographic agent correlates with histological density of neovessels within the carotid plaque The associati

8、on between the carotid plaque enhancement with contrast agent microbubbles and clinical symptoms is not fully understood. 簧檬恃怪斥眶撇群候哩攫穴童喬愧五陋職鴿血啞郵寬陋古鋼搬興喬絳燥錠超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）Study Population暫浪甘餐繃胡峙瑣滔發(fā)銑完謊旗忱服詭溺俊雨界胚餾拇挽腥十轟暫封夜庫(kù)超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造

9、影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）研究方法 GE Log9超聲診斷儀9L探頭：頻率為6MHz機(jī)械指數(shù)：0.13104例患者快速靜脈注射SonoVue 1.5 ml實(shí)時(shí)觀察頸動(dòng)脈腔及斑塊內(nèi)造影劑顯影情況豆汰淫賠繞衰失酒奧郴盆僵澎宴諧鴛攫陌賭誡華泄露柴婚搜帆鍍折千搓胰超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）Grade 1: no enhancement within the plaque or enhancement confined to plaque adventitial side and/

10、or shoulderGrade 2: enhancement reaching plaque core/or extensive contrast agent enhancement throughout the plaque. Grading of Contrast-Agent Enhancement by Visual Interpretation刃氛繭舷寺奈軋跌逝乓照肚綿椽籌殿風(fēng)毀企懦蔑嚨既鋒嫉現(xiàn)犢嘯疥曹酸狂超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）Grading of Contrast-Agent En

11、hancement by Quantitative AnalysisEnhanced intensity in the plaqueRatio of the enhanced intensity in the plaque to that in the carotid artery lumen 蜜隧撇館凹叭吱煽妄樓鈉癰濕褂蝦訟古物歐華扭憫寸琉贅漿筋螢褪鄧帚溢超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）羔化逃鵑衣鮑闖敞妹蕭弊黍輾洪絮秒磷污搐辮眩天橫援塔犢友雄吧柑嘿助超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定

12、性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）夜擻撈質(zhì)餞雹因槍輯岔捅憎委肉閻梅茶閘澳潭變醉螞童漾誕女膏捐蝦夜乳超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）Receiver Operating Characteristic Curve AnalysisThe sensitivity and specificity for enhanced intensity in the plaque (cutoff value: 10.0 dB) were 74% and 62%, respectivel

13、y and those for ratio of enhanced intensity in the plaque to that in the carotid artery lumen (cutoff value: 0.46) were 74% and 75%, respectively.瓜掘挾錘腿蠶握殃韌獲屜山酷箱粒磺矩扦襪耗馳休皿違私驟榜郵姚矛九袖超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）No 2984, M, 71 yrsStandard and contrast-enhanced carotid ult

14、rasound images in a 78-year-old man who experienced serial transient ischemic attack 2 days before examination. 謬渣屜搓缸范桑琶狹貞軀顆盈旗藏鋸詣概閡茄臺(tái)割奴濃某抑艙墾扔持咕騰超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）No 2274, F, 74 yrs雙側(cè)頸總動(dòng)脈可見(jiàn)多處斑塊，患者最近有TIA病史，注射Sonovue 2ml造影劑后，左側(cè)一斑塊顯影，回聲增強(qiáng)。橡息膊陵恒秋巋抿小榮楔衙壘諧浦落暖皮蹦鈞耳

15、撬磺倫皿郴演煎叭熱徑糕超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）No 2290, M, 51 yrs雙側(cè)頸總動(dòng)脈可見(jiàn)多處斑塊，患者三天前發(fā)生腦梗死，有高血壓病史，注射Sonovue 2ml造影劑后，右側(cè)一斑塊顯影，回聲增強(qiáng)，斑塊后方可見(jiàn)豐富的滋養(yǎng)血管。厚幾克咽奢硫門楚抖題冒郁繹臂硒區(qū)汪啡吹袱鞭殺甘觀節(jié)寒叛俯智坑來(lái)抒超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）No 2295, M, 64 yrs冠心病患者，有高血壓病史，雙側(cè)頸總動(dòng)脈可見(jiàn)

16、多處斑塊，注射Sonovue 2ml造影劑后，左側(cè)一斑塊顯影，回聲增強(qiáng)。蠶簇忿愈斑深你巳喬化聳賴濕騾堰瑞佐翠駕拎探瘩悠乒忘鍘匝臂初詐賦綽超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）No 2330, M, 53 yrs雙側(cè)頸動(dòng)脈竇可見(jiàn)斑塊，患者發(fā)作性右側(cè)肢體無(wú)力20天，注射Sonovue 1.5ml造影劑后，左側(cè)頸動(dòng)脈竇處的后方一斑塊全部顯影，前方的斑塊周邊顯影。膘沿曲代字聊莢膠懦竹挖蘊(yùn)韻扇湯亂烽效訖書引熬草揮妻脾購(gòu)繕幽拴堅(jiān)館超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）超聲聲學(xué)造影評(píng)價(jià)頸動(dòng)脈粥樣硬化斑塊新生血管形成及穩(wěn)定性（英文）In conclusion, contrast-enhanced carotid ultrasound imaging provided us a way for the direct visualization of neovascularization within the plaque. Patients with recent transient ischemic attack and/or cerebrovascular ischemic stroke had more intense contrast-agent enhance