Vidofludimus-4sc-101-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEVidofludimusCat. No.: HY-14908CAS No.: 717824-30-1Synonyms: 4sc-101; SC12267分式: CHFNO分量: 355.36作靶點(diǎn): Interleukin Related作通路: Immunology/Inflammation儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) D

2、MSO : 46 mg/mL (129.45 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.04 mM); Suspended solution; Need ultrasonic2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (7.04 mM); Suspended solution; Need ultrasonic3

3、. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.04 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Vidofludimus(4SC-101; SC12267)是免疫抑制劑，能抑制DHODH，在不影響淋巴細(xì)胞增殖的條件下抑制IL-17的分泌。REFERENCES1. Fitzpatrick LR, et al. Vidofludimus inhibits colonic interleukin-17 and improves hapten-induced colitis in rats

4、by a unique dual mode ofaction. J Pharmacol Exp Ther. 2012 Sep;342(3):850-60.2. Fitzpatrick LR, et al. 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models ofinflammatory bowel disease. Inflamm Bowel Dis. 2010 Oct;16(10):1763-77.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 0