Doripenem-monohydrate-S-4661-monohydrate-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDoripenem (monohydrate)Cat. No.: HY-B0187ACAS No.: 364622-82-2Synonyms: S 4661 monohydrate分式: CHNOS分量: 438.52作靶點(diǎn): Bacterial作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO :

2、 50 mg/mL (114.02 mM; Need ultrasonic)H2O : 10 mg/mL (22.80 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.2804 mL 11.4020 mL 22.8040 mL5 mM 0.4561 mL 2.2804 mL 4.5608 mL10 mM 0.2280 mL 1.1402 mL 2.2804 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?/p>

3、，配制前請(qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 3 mg/mL (6.84 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 3 mg/mL (6.84 mM); Clear solution1/2

4、 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 3 mg/mL (6.84 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Doripenem合物譜的-內(nèi)酰胺抗素，抗 譜覆蓋蘭陽(yáng)性，陰性和厭氧菌。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00282-18. Biomed Res Int. 2018 Jul 2;2018:3579832

5、.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Anderson DL. Doripenem. Drugs Today (Barc). 2006 Jun;42(6):399-404.2. Jones RN, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidalaction and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792