Biapenem-CLI-86815-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBiapenemCat. No.: HY-13573CAS No.: 120410-24-4Synonyms: CLI 86815; L 627; LJC 10627分式: CHNOS分量: 350.39作靶點: Bacterial作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 H2O : 20 mg/m

2、L (57.08 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.8540 mL 14.2698 mL 28.5396 mL5 mM 0.5708 mL 2.8540 mL 5.7079 mL10 mM 0.2854 mL 1.4270 mL 2.8540 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Biapenem (CLI 86815)不經(jīng)腸道的譜碳 霉烯抗素。IC50 & Target Antiba

3、cterial 1.體外研究Biapenem (CLI 86815) is a carbapenem antibiotic of in vitro antibacterial activity encompassing manyGramnegative and Gram-positive aerobic and anaerobic bacteria, including species producing -lactamases.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBiapenem (CLI 86815) is more stabl

4、e than imipenem, mero-penem and panipenem to hydrolysis by humanrenal dihydropeptidase-I (DHP-I), and therefore does not require the coadministration of a DHP-I inhibitor. Inrandomised, nonblind or double-blind clinical trials, biapenem showed good clinical and bacteriologicalefficacy (similar to th

5、at of imipenem/ cilastatin) in the treatment of adult patients with intra-abdominalinfections, lower respiratory infections or complicated urinary tract infections.戶使本產(chǎn)品發(fā)表的科研獻 Biomed Res Int. 2018 Jul 2;2018:3579832.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Perry, C.M. an

6、d T. Ibbotson, Biapenem. Drugs, 2002. 62(15): p. 2221-34; discussion 2235.2. Kasahara, S., et al., Clinical effects of biapenem on febrile neutropenia in patients with hematological malignancy. Jpn J Antibiot, 2008.61(3): p. 115-21.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-8