Piperazine-Erastin - Ferroptosis Activator - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPiperazine ErastinCat. No.: HY-100887CAS No.: 1538593-71-3分式: CHClNO分量: 645.19作靶點(diǎn): Ferroptosis作通路: Apoptosis儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 33.33 mg/mL (51.66 mM; Need ultra

2、sonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (3.87 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (3.87 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Piperazine erastinerastin的類似物，其誘導(dǎo)鐵離依賴形式的凋亡性細(xì)胞死亡，稱為鐵死亡。

3、體外研究 Erastin is a ferroptosis activator. It triggers a unique iron-dependent form of non-apoptotic cell death that istermed as ferroptosis. Piperazine erastin is a more effective analog of erastin which is more water-soluble(0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabol

4、ically stable. Piperazineerastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds 1.體內(nèi)研究 In the xenograft mouse model, a significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the

5、vehicle-treated group. Ptgs2 is upregulated in mouse liver with 10 or 60 mg/kgpiperazine erastin administration 1.PROTOCOLAnimal Mice: Athymic nude mice are injected with four million HT-1080 cells s.c. The next day, 400 L of vehicleAdministration 1 (0.625% DMSO/99.375% HBSS pH 2) or 40 mg/kg pipera

6、zine erastin is delivered to the s.c. site wherecancer cells are injected. Two days later, the s.c. injection is repeated. Three days later, 300 L of vehicle or30 mg/kg piperazine erastin is administered to the mice through tail vein. Tail vein injection is repeated threemore times, once every other

7、 day before the final tumor size is measured in both groups 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Redox Biol. 2019 Jun;24:101211.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Yang WS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 Jan 16;156(1-2):317-331.McePdfHeightCaution: Product has not been fully validated for medical applications.For resear