Revizinone-R80122-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERevizinoneCat. No.: HY-100615CAS No.: 133718-29-3Synonyms: R80122分式: CHNO分量: 459.54作靶點(diǎn): Phosphodiesterase (PDE)作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO :

2、4.6 mg/mL (10.01 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.1761 mL 10.8804 mL 21.7609 mL5 mM 0.4352 mL 2.1761 mL 4.3522 mL10 mM 0.2176 mL 1.0880 mL 2.1761 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Revizinone個(gè)新的有選擇性的phos

3、phodiesterase (PDE) III抑制劑，在酶檢測(cè)實(shí)驗(yàn)上的IC50值是0.036microM。REFERENCES1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE1. Herregods L et al. Haemodynamic effects of R 80122 immediately after cardiopulmonary bypass; preliminary results. Anaesthesia. 1994Aug;49(8):719-22.2. Schneider J et al. Cardiac effects

4、 of R 79595 and its isomers (R 80122 and R 80123) in an acute heart failure model. A new class ofcardiotonic agents with highly selective phosphodiesterase III inhibitory properties. Naunyn Schmiedebergs Arch Pharmacol. 1992Nov;346(5):563-72.3. de Cheffoy de Courcelles D et al. Inhibition of human c

5、ardiac cyclic AMP-phosphodiesterases by R 80122, a new selective cyclic AMP-phosphodiesterase III inhibitor: a comparison with other cardiotonic compounds. J Pharmacol Exp Ther. 1992 Oct;263(1):6-14.4. Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymesin vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3