Leu5-Enkephalin-Leu-enkephalin-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELeu5-EnkephalinCat. No.: HY-P0288CAS No.: 58822-25-6Synonyms: Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin分式: CHNO分量: 555.62Sequence: Tyr-Gly-Gly-Phe-LeuSequence Shortening: YGGFL作靶點(diǎn): Opioid Receptor; Endogenous Metabol

2、ite作通路: GPCR/G Protein; Neuronal Signaling; MetabolicEnzyme/Protease儲(chǔ)存式: Powder -80C 2 years-20C 1 yearIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 150 mg/mL (269.97 mM)H2O : 100 mg/mL (179.98 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentrati

3、on制備儲(chǔ)備液1 mM 1.7998 mL 8.9990 mL 17.9979 mL5 mM 0.3600 mL 1.7998 mL 3.5996 mL10 mM 0.1800 mL 0.8999 mL 1.7998 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Leu5-Enkephalin種具有嗎啡藥性的五肽。作為阿受體 (opioid receptors) 激動(dòng)劑。IC50 & Target Huma

4、n Endogenous Metabolite體外研究 Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptidesfound in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors.Enkephalins are putative endogenous ligands for delta opioid receptors

5、, and dynorphins are endogenousligands for the kappa opioid receptors. Three receptor types resembling the vertebrate - and -type opioidreceptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin)and localized by autoradiography at CHH terminals in the

6、SG of C. maenas 1.Leucine-enkephalin is apentapeptides with morphine like properties, naturally present in mammalian brain 2.REFERENCES1. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.2. Meunier JC, et al. Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 1977 May15;77(2):209-13.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel