Apigenin-7-glucuronide-Apigenin-7-O-glucuronide-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEApigenin-7-glucuronideCat. No.: HY-N1454CAS No.: 29741-09-1Synonyms: Apigenin 7-O-glucuronide分式: CHO分量: 446.36作靶點(diǎn): MMP作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn)

2、DMSO : 65 mg/mL (145.62 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.2403 mL 11.2017 mL 22.4034 mL5 mM 0.4481 mL 2.2403 mL 4.4807 mL10 mM 0.2240 mL 1.1202 mL 2.2403 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，

3、體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (4.86 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (4.86 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn o

4、il1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.17 mg/mL (4.86 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Apigenin-7-glucuronide 能夠抑制質(zhì)屬蛋酶 (MMP) 的活性，其對(duì) MMP-3，MMP-8，MMP-9，MMP-13的IC50 值分別為 12.87，22.39，17.52，0.27 M。IC50 & Target MMP-3 MMP-8 MMP-9 MMP1312.87 M (IC50) 22.39 M (IC50) 17.52

5、M (IC50) 0.27 M (IC50)體外研究 Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39,17.52, 0.27 M for MMP-3, MMP-8, MMP-9, MMP-13, respectively 1. Scutellarin A also inhibits the migratedcapacity of ACHN and 786-O cells in a dose-dependent manner.

6、It is also revealed that after treatment withScutellarin A (30, 60, and 90 M) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkablyenhanced dose-dependently when compared to the control groups 2.REFERENCES1. Crasc L, et al. Correlating In Vitro Target-Oriented Screening and Docking: I

7、nhibition of Matrix Metalloproteinases Activities byFlavonoids. Planta Med. 2017 Jul;83(11):901-911.2. Deng W, et al. Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN. Biomed Pharmacother.2018 Nov;107:1505-1513.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use