ZLN005 - PGC-1α Activator - 生命科學試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEZLN005Cat. No.: HY-17538CAS No.: 49671-76-3分式: CHN分量: 250.34作靶點: PGC-1作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 22 mg/mL (87.88 mM; Need ultrasonic)Mass

2、Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.9946 mL 19.9728 mL 39.9457 mL5 mM 0.7989 mL 3.9946 mL 7.9891 mL10 mM 0.3995 mL 1.9973 mL 3.9946 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分

3、指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.2 mg/mL (8.79 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.2 mg/mL (8.79 mM); Precipitated solution; Need ultrasonicBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 ZLN005新型

4、過氧化物增殖激活受體協(xié)同激活 (PGC-1) 轉(zhuǎn)錄調(diào)節(jié)劑 1。IC50 & Target Peroxisome proliferator-activated receptor- coactivator-1 1體外研究 ZLN005 (2.5-20 M; 24 hours ) activates AMPK in a dose-dependent manner 1.Western Blot Analysis 1Cell Line: L6 myotubesConcentration: 2.5, 5, 10, 20 MIncubation Time: 24 hoursResult: Dose-depe

5、ndent activation of AMPK.體內(nèi)研究 ZLN005 (15 mg/kg; p.o.; per day for 4 weeks) decreases random blood glucose and fasting blood glucoselevels over 4 weeks compared with lean mice 1.Animal Model: Eight-week-old db/db mice 1Dosage: 15 mg/kgAdministration: Oral administration; per day for 4 weeksResult: Ra

6、ndom blood glucose and fasting blood glucose levels decreased significantly over 4weeks compared with lean mice.戶使本產(chǎn)品發(fā)表的科研獻 Int J Mol Sci. 2018 Jun 6;19(6). pii: E1691. Toxicol Appl Pharmacol. 2019 May 11.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Zhang LN, et al. Novel small-molecule PGC-1 transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013Apr;62(4):1297-307.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.T