留學(xué)雅思閱讀2010年模擬練習(xí)題

1、資料中心大學(xué)生大學(xué)生群高考志愿交流畢業(yè)就業(yè)求職群管理/金融2495139195240145720020359925205572427668012525667911124944053310878529652028325250469437250469437202486294群學(xué)生家長職業(yè)培訓(xùn)青年創(chuàng)業(yè)交流教師資格 群2010年雅思閱讀精選模擬練習(xí)題Why did a promising heart drug fail?Doomed drug highlights complications of meddlingwithcholesterol.1.The failure of a high-prof

2、ile cholesterol drug has thrown a spotlighton the complicated machineryt regulates cholesterol levels. But many researchersremainconfidentt drugsto boost levels of good cholesterol are still oneof themost promising meansto combat spiralling heart disease.2.Drug company Pfizer announced on 2 December

3、t it was cancelling allclinical trials of torcetrapib, a drug designed to raise heart-protectivehigh-density lipoproteins (HDLs). In a trial of 15000 patients, a safety boardfoundt more people died or suffered cardiovascular problems after taking thedrug plus a cholesterol-lowering shan those in a c

4、ontrol group who tookthe sin alone.3.The news came as a kickhe teeth to many cardiologists because earrtests in animals and people suggested it would lower rates of cardiovascular disease.There have been no red flags to my knowledge, says John Chapman,a spelistin lipoproteins and atherosclerosis at

5、the National Institute for Healnd MedicalResearch (INSERM) in Paris who has also studied torcetrapib. Thiscancellationcame as a complete shock.called cholesterol ester transfrotein (CETP), which normally transfers thecholesterol from high-density lipoproteins to low density, plaque-promoting ones.Si

6、ns, in contrast, mainly work by lowering the bad low-density lipoproteins.Undrere5.Researchers are now trying to work out why and how the drug backfired,somethingt will note clear until the clinical details are released byPfizer. One hs in evidence from earr trialst it slightly raises bloodprere in

7、some patients. It was thoughtt this mild problem would be offsetby the heart benefits of the drug. But it issiblet it actually proved fatalin some patients who already suffered highblood prere. If blood prere isthe explanation, it would actually be good news for drug developers because itsuggestst t

8、he problems are specific to this compound. Othrototype drugst are being developed to block CETP work in a slightly different way and mightnot suffer the same downfall.6.But it is also sible t the whole idea of blocking CETP is flawed,says Moti Kashyap, who directs atherosclerosis research at the VA

9、Medical Centerin Long Beach, California. When HDLs excrete cholesterolhe liver, they actuallyrely on LDLs for part of this pros. So inhibiting CETP, which prevents the transferof cholesterol from HDL to LDL, might actually cause an abnormal and irreversibleaccumulation of cholesterolhe body. Youre b

10、locking a physiologic mechanismto eliminate cholesterol and effectively constipating the pathway, says Kashyap.Going up7.Most researchers remain confidentevating high density lipoproteinslevels by one means or another is one of thebest routes for helheart diseasepatients. But HDLs are complex and no

11、t entirely understood. One approved drug,called niacin, is known to both raise HDL and reduce cardiovascular risk but also4. Torcetrapib is one of the most advanced of a new breed of drugs designed to raise levels of HDLs, which ferry cholesterol out of artery-clogging plaques to the liver for remov

12、al from the body. Specifically, torcetrapib blocks a proteincauses an unpleasansation of heat and tingling. Researchers are exploringwhether they can bypass thie effect and whether niacin can lower disease riskmoren sins alone. Scientists are alsoworking on several other means tobumpup high-density

13、lipoproteins by, for exle,roducing synthetic HDLs.Theonly thing we know is deadhe wateris torcetrapib, not the whole ideaof raising HDL, says Michael Miller, director of preventive cardiology at theUniversity of MarylandMedical Center, Baltimore.(613 wordsnature)Questions 1-7This passage has 7paragr

14、aphs 1-7.Choose the correct heading for each paragraph from the list of headings below.Write the correctnumber i-ix in boxes 1-7 on your answer sheet.ListofHeadingsi.How does torcetrapib work?ii.Contradictory result prior to the current trialiii.One failure maysibly bring about future sucsiv.Thefail

15、ure doesnt lead to total loss of confidencev.Itis the right route to followvi.Whyits stoppedvii.They may combine and theoretically produce ideal resultviii.Whats wrong with the drugix.ItmightbewrongattheplaceExleanswerParagraph 1iv1.Paragraph22.Paragraph33.Paragraph44.Paragraph55.Paragraph66.Paragra

16、ph7Questions 7-13Match torcetrapib，HDLs，sin and CETP with their functions (Questions 8-13).Write the correct letter A, B, C or D in boxes 8-13 on your answer sheet.NB You may use any letter moren once.7.Is been administered to over 10,000 subjects in a clinical trial.8.It could help rid human body o

17、f cholesterol.9.Researchers are yet to find more about it.10.It was used to reduce the level of cholesterol.11.According to Kashyap, it might lead to unwanted result if its blocked.12.It produced contradictory results in different trials.13. It could inhibit LDLs.List of choiA. TorcetrapicB. HDLSC.

18、SinD. CETPSuggested Answers and Explanations1. vi2. ii3. vii本段介紹了 torcetrapib 和 sin 的治病原理，但是同時(shí)短語“incontrast”與之前第二段后半段的內(nèi)容呼應(yīng)，暗示了這兩種藥在理論上能相輔相成，是理想的搭配。第一個(gè)選項(xiàng)無法涵蓋整段意義，故選擇 i 是錯(cuò)誤的。4. iii本段分析了可能導(dǎo)致 torcetrapibl 臨床試驗(yàn)失敗的原因，后半段如果以上推測正確，那么未來的藥物可借鑒這個(gè)試驗(yàn)，設(shè)法避免 torcetrapib 的缺陷，研制出有效的藥物。viii 選項(xiàng)無法涵蓋后半段的意思。5.ix見首句。6.v7.A

19、見第二段。題目中 administer 一詞意為“用藥”，subject 一詞為“實(shí)驗(yàn)對象”之意。8. B見第四段“ to raise levels of HDLs, which ferry cholesterol out用最終是將 choleserol 清除出：“ for removal from the body”。9. B見第四段“But HDLs are complex and not entirely understood.”10.C見第二段“ plus a cholesterol-lowering sin”，即 sin是可以降低 cholesterol 的。11.D見第六段“So

20、inhibiting CETP, might actually cause anabnormal and irreversible accumulation of cholesterol he body.12.A見第三段。13.C見第四段“Sins, in contrast, mainly work bylowering the bad low-density lipoproteins.of artery-clogging plaques to the liver for removal from the body.”即 HDLs 的作資料中心http:/大學(xué)生大學(xué)生畢業(yè)就業(yè)求職群管理/金融2495139195240145720020359925205572427668012525667911124944053310878529652028325250469437250469437202486294群群 高考志愿交流交流教師資格 學(xué)生家長職業(yè)培訓(xùn)青年創(chuàng)業(yè)群http:/，好教育 找資料，查課程，好老師學(xué)生大學(xué)生2495139195240145720020