Tri-Amino-PEG3-amide-amine-DataSheet-生命科學(xué)試劑-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemETri(Amino-PEG3-amide)-amineCat.No.:HY-140249分?式:C??H??N?O??分?量:755.94作?靶點:PROTACLinker作?通路:PROTAC儲存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(132.29mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.3229mL6.6143mL13.2286mL5mM0.2646mL1.3229mL2.6457mL10mM0.1323mL0.6614mL1.3229mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實驗結(jié)果的可靠性，體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(2.75mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(2.75mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(2.75mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemE?物活性Tri(Amino-PEG3-amide)-amine?種PROTAClinker，屬于PEG類?？?于合成PROTAC分?[1]。IC50&TargetPEGs(批量添加)體外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseandtheotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemtoselectivelydegradetargetproteins[1].REFERENCES[1].AnS,etal.Small-moleculePROTACs:Anemergingandpromisingapproachforthedevelopmentoftargetedtherapydrugs.EBioMedicine.2018Oct;36:553-562.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5