生物信息學(xué)分析方法

常用的生物信息學(xué)分析方法第十組生物信息學(xué)是一門在生命科學(xué)的研究中，以計(jì)算機(jī)為工具對生物信息進(jìn)行儲(chǔ)存、檢索和分析的科學(xué)。生物信息學(xué)Bioinformatics生物信息學(xué)基本上是分子生物學(xué)與信息技術(shù)的結(jié)合體。研究材料和結(jié)果是各種各樣的生物學(xué)數(shù)據(jù)研究工具是計(jì)算機(jī)研究方法包括對生物學(xué)數(shù)據(jù)的搜索（收集和篩選）、處理（編輯、整理、管理和顯示）及利用（計(jì)算、模擬）節(jié)律基因Timeless數(shù)據(jù)庫MGIhttp數(shù)據(jù)庫NCBI數(shù)據(jù)庫TAIRhttp多序列比對MEGAhttp系統(tǒng)發(fā)育樹MEGAhttp:///tools/meme保守基序分析MEMEhttp基因結(jié)構(gòu)GSDShttp啟動(dòng)子分析PlantCARE基序名稱位置序列特征功能TATA-box254TATAAcorepromoterelementCAAT-box 260CCAATcommoncis-actingelementinpromoterandenhancerregions3-AF1bindingsite50AAGAGATATTTlightresponsiveelementCCAAT-box1051CAACGGMYBHv1bindingsiteCGTCA-motif1294CGTCAMeJA-responsivenessGA-motif 1252ATAGATAAlightresponsiveelementHSE 28AAAAAATTTCheatstressresponsivenessLTR414CCGAAAlow-temperatureresponsivenessMSA-like 568CCCAACGGTcellcycleregulationTGA-element 289AACGACauxin-responsiveelementhttp轉(zhuǎn)錄因子結(jié)合位點(diǎn)分析JASPARMatrixIDNameScoreRelativescoreStartEndStrandPredictedsequenceMA0940.1AP112.570.9011628+acaaaaatgaaatMA0934.1AHL2512.51691328335+aattaattMA0951.1ATHB-1612.24230.964352359+taatgattMA0933.1AHL2012.0060.979328335+aattaattMA0943.1ARF511.84490.97410171024+GCCGACAGMA0947.1ARR1411.81320.965707714+AGATCCGCMA0934.1AHL2511.81260.984333340+atttaatt可視化基因組學(xué)BAR亞細(xì)胞定位SUBAAGISUBAconPredictionsAT5G52910.1nucleusnucleus

cytosol

mitochondrionhttp://www.sbg.bio.ic.ac.uk/~phyre/三級(jí)結(jié)構(gòu)預(yù)測Phyre16-464replication643-747proteinbindinghttp信號(hào)肽預(yù)測SignalPAT5G52910AT1G01070http跨膜結(jié)構(gòu)域預(yù)測TMHMMhttp蛋白互作網(wǎng)絡(luò)STRINGDNArepairpolymerasehelicase序列分析雙序列比對MEGA/Bioedit/bioedit/bioedit.htmlNCBI/GenBank/MEME/tools/meme多序列比對（系統(tǒng)進(jìn)化樹、保守基序）基因分析ORF(Open

Reading

Frame)分析NBCI/orffinder/基因結(jié)構(gòu)分析（外顯子、內(nèi)含子）GSDS/啟動(dòng)子分析PlantCAREhttp://bioinformatics.psb.ugent.be/webtools/plantcare/html/PLACEhttps://sogo.dna.affrc.go.jp/cgi-bin/sogo.cgi?sid=&lang=en&pj=640&action=page&page=newplace轉(zhuǎn)錄因子結(jié)合位點(diǎn)分析TFSEARCHhttp://diyhpl.us/~bryan/irc/protocol-online/protocol-cache/TFSEARCH.htmlJASPAR/表達(dá)模式分析barhttp://bar.utoronto.ca/蛋白分析結(jié)構(gòu)分析二級(jí)PredictProtein

/PSIPREDhttp://bioinf.cs.ucl.ac.uk/psipred三級(jí)Phyrehttp://www.sbg.bio.ic.ac.uk/~phyre/SWISS-MODEL/亞細(xì)胞定位PSORTSUBAhttp://suba.live信號(hào)肽預(yù)測SignalPhttp://www.cbs.dtu.dk/services/SignalP/跨膜結(jié)構(gòu)預(yù)測TMHMMhttp://www.cbs.dtu.dk/services/TMHMM-