Pelcitoclax-APG-1252-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPelcitoclaxCat.No.:HY-109185CASNo.:1619923-36-2Synonyms:APG-1252分?式:C??H??ClF?N?O??PS?分?量:1281.85作?靶點(diǎn):Bcl-2Family;Apoptosis作?通路:Apoptosis儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:200mg/mL(156.02mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM0.7801mL3.9006mL7.8012mL5mM0.1560mL0.7801mL1.5602mL10mM0.0780mL0.3901mL0.7801mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:5mg/mL(3.90mM);Suspendedsolution;Needultrasonic2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥5mg/mL(3.90mM);ClearsolutionBIOLOGICALACTIVITY?物活性Pelcitoclax(APG-1252)?種有效的Bcl-2/Bcl-xl抑制劑，具有抗腫瘤和促凋亡作?。體外研究APG-1252changestothereactivemetabolitenamedAPG-1252-M1,whichhasremarkableantitumoreffectsinacutemyeloidleukemia[1].體內(nèi)研究Pelcitoclax(APG-1252;25-100mg/kg;i.v.;onceaday;for10days)treatmentinhibitsxenografttumorgrowthmoreobviouslythantheothergroups[1].AnimalModel:BALB/cathymicnudemice(male,4-6weeks)injectedwithN87cells[1]Dosage:25mg/kg,50mg/kg,and100mg/kgAdministration:Intravenousinjection;onceaday;for10daysResult:Inhibitedxenografttumorgrowthmoreobviouslythantheothergroups.REFERENCES[1].HanjieYi,etal.Bcl-2/Bcl-xlinhibitorAPG-1252-M1isapromisingtherapeuticstrategyforgastriccarcinoma.CancerMed.2020Jun;9(12):4197-4206.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82