免疫學(xué)課程教學(xué)大綱

免疫學(xué)課程教學(xué)大綱CourseOutline課程基本信息（CourseInformation）課程代碼（CourseCode）

MS310

*學(xué)時64t

*學(xué)分（Credits）

4.0*課程名稱（CourseTitle）*課程性質(zhì)（CourseType）授課對象（TargetAudience）*授課語言(LanguageofInstruction)*開課院系先修課程授課教師

（中文）免疫學(xué)（英文）PrincipleofImmunobiology本科二年級/三年級雙語（漢語+英語）蘇冰

選修課課程網(wǎng)址（Instructor）

(CourseWebpage)*）些主要的實驗手段。并介紹其同其它生命學(xué)科的密切相關(guān)性，和其研究的方法。學(xué)生物學(xué)知識的生物工程學(xué)專業(yè)的學(xué)生。Thiscourseisahalf-yearcoursewhichintroducesthebasicprinciplesofmodernimmunobiology.Itwillfocusonthegeneration,developmentandregulationoftheimmunesystemanditsfunctioninhumanepidemics,immunologicaldiseases,inflammationandtumor.Theaimofthiscourseisnotonlytoelucidatethesekeyprinciplesofimmunology,butalsotodiscussitshistoryofdiscoveryandsomemajor*）

experimentaltechniques.Thecoursewillalsointroducethecloserelationshipofimmunologytotheothersubdisciplinesoflifescienceandresearchmethods.Thiscourseisnotonlysuitableforthestudentswhomajorsinlifescienceormedicalscience,butisalsogoodforthestudentswhomajorinbiomedicalengineeringwhowanttopickupsomebasicknowledgeinimmunology.課程教學(xué)大綱（coursesyllabus）免疫系統(tǒng)組成和功能。Introductiontotheimmunesystem.理解免疫細胞的免疫學(xué)功能。Describeinnateimmunerecognition.UnderstandInflammation,infectionandacutephaseresponses.DiscussimmunologicalFunctionofinnateimmunecells,suchasmonocyte,macropahgeandDC,etc.T,B淋巴細胞的發(fā)育，了解淋巴細胞抗原受體基因結(jié)構(gòu)和V(D)J排。DescribethedevelopmentofTandBcells.RecognizetheTCRandBCRgenestructuresandV(D)Jrearrangement.TTT細胞激活和T細胞亞群的分化及T細胞的功能。DescribeTCellreceptorandantigenrecognition.UnderstandTlymphocytematurationandmigrationintheLymphoidOrgans.DescribeTcellactivation,differentiationandthefunctionofeffectorTcells.*學(xué)習(xí)目標(biāo)(LearningOutcomes)

認(rèn)識B細胞介導(dǎo)的免疫應(yīng)答和生發(fā)中心的反應(yīng)，理解Ig類別轉(zhuǎn)換、體細胞高頻突變和抗體親和力成熟認(rèn)識免疫球蛋白分子結(jié)構(gòu)分類和功能Recognize B cell mediated immune response and germinal center reacyion.UnderstandIgclassswitch,somatichypermutationandaffinitymaturation.Describethestructure,classificationandfunctionofimmunoglobulin.B和TRecognizeandcomparethedifferenceofBCRandTCRsignaltransduction.Recognizethecytokinesandsignalingpathways.MHCMHCIII類分子抗原提呈的區(qū)別。DescribeMHCgeneandstructure.ComparethedifferenceofMHCImoleculeandMHCIImoleculepresentingantigen.記憶，了解疫苗的功能。Recognizeimmuneevolution. Understandtheinductionoftheadaptiveimmunitybyinnateimmuneresponseandimmunologicalmemory.Describethefunctionofvaccine.認(rèn)識黏膜免疫的組成和功能。Recognizemucosalimmunesystemandmucosalimmunity.認(rèn)識抗感染免疫的具體機制。Recognizeimmuneresponsetoinfection(virus,fungi,bacteria).認(rèn)識腫瘤免疫逃逸及機體抗腫瘤免疫。Understandtheimmunologicalprinciplesoftumorimmuneescape,anti-tumorimmunity.理解移植排斥的免疫學(xué)原理。Understandtheimmunologicalprinciplesoftransplantrejection.認(rèn)識免疫缺陷，認(rèn)識自身免疫病的病理損傷機制和相關(guān)治療。Recognizeimmunodeficiency.Understandpathologicaldamagemechanismandtherapeuticprincipleofautoimmunedisease(suchasSLE、RA、Diabetesetc.).教學(xué)內(nèi)容Introductiontothe

學(xué)時 教學(xué)方式 作業(yè)及要求基本要求 考查方式ImmuneSystemInnateImmuneSystemInnateImmuneRecognition4課堂教學(xué)預(yù)復(fù)習(xí)andInflammationDevelopmentof6課堂教學(xué)預(yù)復(fù)習(xí)LymphocytesAdaptiveImmuneReceptorand4課堂教學(xué)預(yù)復(fù)習(xí)AntigenRecognitionTCRandBCRsignal4課堂教學(xué)預(yù)復(fù)習(xí)transductionGenerationandRegulationof4課堂教學(xué)預(yù)復(fù)習(xí)AdaptiveImmunityMHCandAntigen8課堂教學(xué)預(yù)復(fù)習(xí)Presentation*教學(xué)內(nèi)容、進度安排及要求(ClassSchedule&Requirements)2課堂教學(xué)預(yù)復(fù)習(xí)10課堂教學(xué)2課堂教學(xué)預(yù)復(fù)習(xí)10課堂教學(xué)預(yù)復(fù)習(xí)10課堂教學(xué)預(yù)復(fù)習(xí)ImmunityandAdaptiveImmunity,MemoryTheImmuneSysteminHealthandDisease*考核方式(Grading)*教材或參考資料(Textbooks&OtherMateri