Patent Rights Purchase Agreement專利購買合同

-23-PatentRightsPurchaseAgreement專利購買合同核心提示：ThisPatentRightsPurchaseAgreement(thisAgreement)ismadeandenteredintoasof_________,_________,_________(M,D,Y).(theEffectiveDate)betweenAAA,Inc.(AAA),andDDD,Inc.(DDD).1.DEFINITIONS.1.1CationicLipidmeansthosecompoundsdThisPatentRightsPurchaseAgreement(thisAgreement)ismadeandenteredintoasof_________,_________,_________(M,D,Y).(theEffectiveDate)betweenAAA,Inc.(AAA),andDDD,Inc.(DDD).1.DEFINITIONS.1.1CationicLipidmeansthosecompoundsdescribedinUnitedStatesPatentNos._________and_________;UnitedStatesPatentApplicationSerialNo._________;andEuropeanPatentApplicationNo._________,totheextentsuchcompoundsarenotCodeblockerCompounds.1.2CodeblockerCompoundmeansanoligonucleotidethatbindsdirectlytoDNAorRNAwithinacellonaselectivebasisdeterminedbythenucleotidesequenceofthetargetDNAorRNAandexertsitsbiologicalactivitypredominantlythroughbindingtoDNAorRNAtoinhibitthetranscriptionorreplicationofthetargetDNAorRNAorbindingtoRNAtoinhibitthetranslation,processing,packagingorregulatoryactivityofthetargetRNA.ACodeblockerCompoundmayalsohaveamechanismofactionorbiologicalactivityotherthanoneconferredthroughdirectbindingtoRNAorDNAprovidedthat(i)thecompoundoriginallywasdesignedtobindatargetDNAorRNAand(ii)thefinalcompoundoranycompoundsusedtoderivethefinalcompoundwerenotidentifiedusingselectivepurificationandpolymeraseamplificationinanyfashion.Anoligonucleotide,isanyoligomerorpolymermadeup_________AnoligonucleotideincludesRNAorDNAfragments,andmaybecomposedofnaturallyoccurringornon-naturallyoccurringbases,sugarsorintersugarlinkages.Anoligonucleotidemayhavethebases,sugarsorintersugarlinkagespartiallyorcompletelyabsent.Oligonucleotidesmaybemadesuchthatadjacentnucleosideornucleosidefragmentsarelinkedtogetherbyphosphategroupsormodifiedornon-naturallyoccurringinternucleosidelinkagestoformtheinternucleosidebackboneoftheoligomer,whetherornotsuchlinkagesretainaphosphorousatominthelinkage.1.3OligonucleotideDeliverySystemmeansanycarrier,targetingentity,excipient,formulation,device,prodrug,covalentornoncovalentconjugate,encapsulatingvesicle,microcapsule,micro-ornanosphere,emulsion,ormicroemulsion,lipid,liposome,virosome,orartificialvialenvelopewhichwasdevelopedbyDDDonorpriortotheEffectiveDate,andwhich(i)enhancesthecellularpenetrationorcirculatinghalf-lifeofaCodeblockerCompound,(ii)selectivelydeliversaCodeblockercompoundtotheintendedtargettissue,cellorsubcellularcompartment,(iii)providessustainedreleaseofaCodeblockerCompoundfromadepotformulation,or(iv)otherwisefavorablyalterstheabsorption,distribution,metabolismorexcretionofaCodeblockerCompoundsoastoenhanceitspharmacologicalactivityofclinicalvalue.OligonucleotideDeliverySystemincludescationiclipids.1.4PatentRightsmeansthepatentsandpatentapplicationslistedinExhibitAattachedhereto.2.ASSIGNMENTSANDLICENSES.2.1DDDherebysellsandassignstoAAAallofDDD’sright,titleandinterestinPatentRights,subjecttotherightsofEEEInc.(EEE)undertheCollaborativeResearchAgreementbetweenEEEandDDDdated_________,_________,_________(M,D,Y)(theEEEAgreement),providedhowever,thattheassignmentofU.S.PatentNumber_________shallbesubjecttotheconditionprecedentthatDDDsettletheinterferenceinvolvingthispatentonconditionsofDDD’schoosing(includingconcedingpriority).DDDherebygrantsAAAanexclusive,royalty-free,worldwide,assignablelicense(withtherighttograntsublicenses)toU.S.PatentNumber_________beginningontheEffectiveDateandcontinuinguntilsuchtimethatDDDsettlestheinterferenceandtheassignmenttoAAAbecomeseffective.2.2DDDherebyassignsanddelegatestoAAA(andAAAacceptsandagreestoperform)allofDDD’srightsandobligationsundertheLicenseAgreementbetweenFFFCorporation(FFF)andDDDdated_________,_________,_________(M,D,Y)andamendedon_________,_________,_________(M,D,Y).AcopyofthewrittenconsenttosuchassignmentanddelegationsignedbyFFFisattachedheretoasExhibitB.IntheeventthatAAA,byreasonofthisAgreement,isrequiredtoindemnifyFFFunderSection8.1(b)oftheFFFLicenseAgreement,DDDwillindemnifyAAAuptoamaximumamountequaltoonehundredpercent(100%)oftotalroyaltiesreceivedbyDDDfromFFF;thereafter,DDDwillnothaveanyindemnityobligationstoAAArelatedtosuchAgreement.DDDwillcontinuetohonoritsobligationstoFFFforactivitiesprecedingtheEffectiveDateofthisAgreement.2.3SubjecttotherightsofFFFabove,AAAherebygrantstoDDDanexclusive,perpetual,irrevocable,royalty-free,worldwide,assignablelicense(withtherighttograntsublicenses)todirectlyorindirectlymake,havemade,use,import,exportorsellcompoundsandothersubjectmatterfallingwithinthescopeofPatentRightswhichare_________2.4DDDherebygrantstoAAAanonexclusive,perpetual,royalty-free,worldwide,assignablelicense(withtherighttograntsublicenses)tocompoundsandothersubjectmatterwhicharewithinthescopeofPatentRights,solelyforuseasintermediatesinthemanufactureofCodeblockerCompoundsoroligomers_________2.5AAAherebygrantstoDDDanon-exclusive,non-sublicensable,non-assignable,perpetual,irrevocable,royalty-free,worldwidelicenseunderPatentRightstomakeanduseCodeblockerCompoundsandOligonucleotideDeliverySystemsforinternalresearchpurposes,butnotforanycommercialpurpose.2.6AAAwillnothaveanyobligationstoDDDrelatingtoCodeblockerCompoundsorthisAgreementtotheextentarisingpriortotheEffectiveDate.2.7EachpartyherebyagreestoexecutesuchdocumentsandtotakesuchotheractionsasshallbenecessaryorappropriatetoeffectuatetheassignmentsandlicensessetforthinthisSection2.3.REPRESENTATIONSANDWARRANTIESBYDDD.DDDmakesthefollowingrepresentationsandwarrantiestoAAA,eachofwhichwillsurvivetheEffectiveDate:3.1TothebestofDDD’sknowledge,thePatentRightsincludeallofthepatentsandpatentapplicationsownedorcontrolledbyDDDonorpriortotheEffectiveDatethatcoverCodeblockerCompoundsandOligonucleotideDeliverySystems,theirmanufactureoruse.TherearenootherUSorunpublishedforeignfilingsownedorcontrolledbyDDDfiledpriortotheEffectiveDatewhichclaimCodeblockerCompoundsorOligonucleotideDeliverySystemsotherthanassetforthinExhibitA,nordoesDDDhaveanypresentintentiontomakesuchfilings.IfDDDbecomesawareofanypatentsorpatentapplicationsthat(i)areownedorcontrolledbyDDD,(ii)claiminventionsmadepriortotheEffectiveDate,(iii)coverCodeblockerCompoundsorOligonucleotideDeliverySystems,and(iv)arenotincludedinExhibitA,DDDwillpromptlynotifyAAAinwritingandexecuteappropriatedocumentstotransfersuchpatentsandpatentapplicationstoAAA.3.2DDDrepresentsandAAAacknowledgesthat(i)theEEEAgreementremainsineffectandDDDandEEEhaveongoingrightsandobligationsthereunder,modifiedtotheextentspecificallysetforthinthisAgreementand(ii)thisAgreementisnotanassignmentofDDD’srightsorobligationsundertheEEEAgreementandthatAAAassumesnorightsorobligationstoEEEunderthisAgreement.DDDrepresentsthattheResearchTermandallrights,obligationsandfundingrelatingtheretoundertheEEEAgreementhavebeenterminated.DDDwillnotenterintoanyfutureamendmentstotheEEEAgreementwhichinanywayaffecttherightsofAAAhereunder.3.3TheEEEAgreementandthelicensetoFFFreferencedinSection2.2abovearetheonlylicensesandDDDisnotawareofanyotherthirdpartyrightsofanykindaffectingthePatentRights.ExceptwithrespecttoU.S.PatentNumber_________,whichissubjecttoaninterferenceproceeding,thePatentRightsarenotthesubjectofanypendinginterference,cancellationorotherprotestproceedingnototherwiseknowntoAAA,orotherwisesubjecttorightsorobligationstoanythirdpartyotherthanEEEandFFF.ThecompletetermsandconditionsofsuchrightsandobligationsrelatingtoEEEandFFFhavebeendisclosedtoAAA.3.4TherearenoCollaborationCompounds(asdefinedinSection1.7oftheEEEAgreement)andnoneweredevelopedduringtheResearchTermundertheEEEAgreement.DDDdoesnotoweanyroyaltiestoEEEoranythirdpartyundertheEEEAgreementnordoesDDDhaveanyknownorpendingclaimsagainstEEEarisingoutoftheEEEAgreement.TothebestofDDD’sknowledge,(i)EEEdoesnotoweanyroyaltiestoDDDoranythirdpartyundertheEEEAgreement,(ii)nordoesEEEhaveanyknownorpendingclaimsagainstDDDarisingoutoftheEEEAgreement.4.TECHNOLOGYTRANSFER.4.1DDDandAAAwillcooperateinthefilingandexecutionofanyandalldocumentsnecessarytoeffectuatetheassignmenttoAAAofthePatentRights,includingthefilingofassignmentsorothertransferoftitlecovenantswiththeU.S.PatentandTrademarkOfficeandforeignpatentofficesasapplicabletothePatentRights.Withinthirty(30)daysfromtheEffectiveDate,DDDwillnotifyallattorneyshandlingtheprosecutionofthePatentRightstocontacttheAAAPatentDepartmenttoprovideanimmediatestatusupdateonthePatentRightsandtopreparethedocumentsnecessarytotransferthePatentRightstoAAA.ThecostofrecordingassignmentsofthePatentRightswillbebornebyAAA.Withinforty-five(45)daysfromtheEffectiveDate,DDDanditscounselwillusetheirreasonablebesteffortstotransferallfilesandsupportingdocumentsrelatingtothePatentRightstoAAA,includingbutnotlimitedto,allinitialinventiondisclosuredocuments,alldocumentssenttotheU.S.PatentandTrademarkOfficeregardinginventionsandclaims,alldraftpatentapplications,allfilingorprosecutiondocumentssubmittedtothepatentoffices,andallfilewrappers.ConceptionnotebooksandallotherdocumentsinthepossessionorunderthecontrolofDDDoritscounselrelatingtoconceptionand/orreductiontopractice,suchasscientistnotebooksshallbeobtainedinaccordwithDDD’sordinarydocumentretentionandmadeavailabletoAAAuponAAA’reasonablerequest.AlldocumentstobeprovidedtoAAAhereunderaretobesentbyexpediteddeliveryservice.4.2DDDwillmakeappropriatescientificstaffavailabletoAAAforascientifictutorialonthesubjectmatterofthisAgreement,suchtutorialnottoexceedmorethan[***]fromDDD’sstaffandnottoobligateDDDtodiscloseanythirdpartyconfidentialinformation.5.PATENTMAINTENANCEANDPROSECUTIONRESPONSIBILITIES.5.1OnandaftertheEffectiveDate,AAAwilltakeresponsibilityforanyactionorproceedinginvolvingPatentRights.ThecostofrecordingtheassignmentofPatentRightsshallbebornesolelybyAAA.IfAAAelectsnottotakesuchresponsibilityinvolvingPatentRight(s)inaparticularcountrythenAAAwilltimelynotifyDDDandEEE30daysbeforethetimefutureactionisdue,andthereafterDDDorEEEshallundertakesuchresponsibility.IfDDDorEEEelectstodoso,AAAwillgrantanynecessaryauthoritytoDDD.DDDwilldeterminewhetherDDDorEEEshalltakesuchresponsibilityattheirexpense.AAAassumesnoobligationtoEEEasaresultofitsagreementwithDDDinthisSectionNOTICEOFINFRINGEMENT.AAAshallpromptlynotifyDDDinwritingofanyinfringementofanyassignedPatentRight(s)ofwhichitbecomesaware.5.3ENFORCEMENTOFPATENTS.ExceptasotherwisesetforthinthisSection,AAAmay,butshallnotberequiredto,prosecuteanyallegedinfringementorthreatenedinfringementofanyassignedPatentRight(s)ofwhichitisawareorwhichisbroughttoitsattention.AAAshallactinitsownnameandatitsownexpense.IfAAAhasfailedtoprosecuteunderthefirstsentenceofthisparagraphwithrespecttoallegedorthreatenedinfringementrelatingtoanyPatentRight(s)(i)twomonthsafterithasbeennotifiedinwritingofsuchallegedinfringement,or(ii)onemonthbeforethetimelimit,ifany,setforthintheappropriatelawsandregulationsforthefilingofsuchactions,whichevercomesfirst,DDD(oratitselectionEEE)may,butshallnotberequiredto,prosecuteanysuchallegedinfringementorthreatenedinfringementofaPatentwithinthePatentRights.Inanysuchevent,DDDorEEEshallbefreetoactinitsownnameandatitsownexpense.Notwithstandingtheforegoingandasbetweentheparties,DDDshallhavethesoleandexclusiverightofenforcementwithrespecttoanyallegedorthreatenedinfringementofanyrightwithinthescopeofthelicensegrantedinSection2.3ofthisAgreement.AAAshallcooperatefullywithDDDorEEEinanyactionbyDDDorEEE,respectively,underthisparagraph,includingifrequiredinordertobringsuchanaction,thefurnishingofapowerofattorney.6.INDEMNITYANDWARRANTY.6.1INDEMNITYBYAAA.AAAwillindemnify,save,defendandholdDDDanditsagents,directorsandemployeesharmlessfromandagainstanyandallsuits,claims,actions,demands,liabilities,expensesand/orloss,includingreasonablelegalexpenseandattorneysfees,resultingfromactivitiesunderthisagreementbyAAA.6.2INDEMNITYBYDDD.DDDwillindemnify,save,defendandholdAAAanditsagents,directorsandemployeesharmlessfromandagainstanyandallsuits,claims,actions,demands,liabilities,expensesand/orloss,includingreasonablelegalexpenseandattorneyfees,resultingfrom(i)DDD’s,DDD’ssublicensee’sorDDD’sassignee’sactivitiesunderthelicensesprovidedforinSections2.3and2.5;(ii)DDD’scontractualobligationstothirdpartiesincludingEEEandFFF,excepttotheextentresultingfromAAA’activitiesunderthisAgreement;or(iii)DDD’sexerciseofthePatentRightspriortotheEffectiveDate.6.3WARRANTY.DDDwarrantsthatithassufficientrightandtitletoenterintoandtoperformitsobligationsunderthisAgreement.EXCEPTASEXPRESSLYSETFORTHINTHISAGREEMENT,THEPARTIESDISCLAIMALLWARRANTIESOFANYNATURE,EXPRESSORIMPLIED,INCLUDINGWITHOUTLIMITATIONWARRANTIESOFVALIDITY,MERCHANTABILITY,NONINFRINGEMENT,ANDFITNESSFORAPARTICULARPURPOSE.7.CONFIDENTIALITY.ConfidentialInformationunderthetermsofthisAgreementisallinformationrelatingtothePatentRightssold,assignedorlicensedtoAAAunderSection2.1andtheTechnologyTransfertoAAAbyDDDunderSection4.1.DDDagreestotreattheConfidentialInformationasconfidentialandtoprotectandmaintaintheconfidentialitythereof.DDDwilluseatleastthesamestandardofcareasitusestoprotectitsownConfidentialInformationtoensurethatitsemployees,agents,andconsultantsdonotdiscloseormakeanyunauthorizeduseofsuchConfidentialInformation.DDDwillpromptlynotifyAAAupondiscoveryofanyunauthorizeduseordisclosureoftheConfidentialInformation.ConfidentialInformationwillnotincludeanyinformationwhichisgenerallyavailabletothepublic,isotherwisepartofthepublicdomainotherthanthroughanyactoromissionofDDDinbreachofthisAgreement,orwhichisrequiredtobedisclosedbylaworcontractenteredintopriortothisAgreement(providedthatAAAshallhavenoticethereofinadvancesothatitcanacttoprotectitsinterestsshoulditdecidetodoso).8.CONSIDERATION.AAAshallpayDDDthefollowingnoncontingent,non-refundablecashpaymentsasconsiderationfortheassignmentsprovidedforinthisAgreement:$,_________ontheEffectiveDate,$,_________onthefirstanniversaryoftheEffectiveDate,$,_________onthesecondanniversaryoftheEffectiveDate,and$,_________onthethirdanniversaryoftheEffectiveDate,fortotalpaymentsof$,_________.IntheeventthatAAAdefaultsonanyofthesepayments,afterthirty(30)daysnoticeandanopportunitytocure,thenownershipofallPatentRightswillautomaticallyreverttoDDDandAAAwilltakeallactionsreasonablyrequestedbyDDDforsuchpurposes,including,withoutlimitation,signinganddeliveringanyapplicableassignmentsandotherdocuments.AAAshallbeentitledtonodamagesexceedingtheconsiderationsetforthinthisSection8foranyuncuredclaimagainstDDDrespectingDDD’sperformanceorrepresentationshereunder.9.NOTICES.NoticesunderthisAgreementshallbesufficientonlyifpersonallydelivered,deliveredbyamajorcommercialrapiddeliverycourierservice,facsimileormailedbycertifiedorregisteredmail,returnreceiptrequested,toapartyatitsaddressessetforthasfollows:IftoAAA:AAA,Inc.Address:_________Attn:_________Facsimile:_________IftoDDD:Address:_________Attn:_________Facsimile:_________IftoEEE:Address:_________Attn:_________Facsimile:_________10.MISCELLANEOUS.IfanyprovisionofthisAgreementshallbeadjudgedbyanycourtofcompetentjurisdictiontobeunenforceableorinvalid,thatprovisionshallbelimitedoreliminatedtotheminimumextentnecessarytocontinuetoeffecttheintentoftheparties,andthisAgreementshallotherwiseremaininfullforceandeffectandenforceable.Anywaiversoramendmentsshallbeeffectiveonlyifmadeinwritingandsignedbyarepresentativeoftherespectivepartiesauthorizedtobindtheparties.ThisAgreementshallbegovernedbythelawsoftheStateofDelaware,excludingconflicts-of-lawprinciples.ThisAgreementisthecompleteandexclusivestatementofthemutualunderstandingofthepartiesandsupersedesandcancelsallpreviouswrittenandoralagreementsandcommunicationsrelatingtothesubjectmatterofthisAgreement,excludingtheConfidentialDisclosureAgreementbetweenthepartiesdated_________,_________,_________(M,D,Y).INWITNESSWHEREOF,thepartieshaveexecutedthisAgreementasofthedayandyearfirstindicated