Antibacterial-agent-117-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAntibacterialagent117Cat.No.:HY-W282615CASNo.:341944-06-7分?式:C?H?ClN?S分?量:240.71作?靶點(diǎn):Bacterial作?通路:Anti-infection儲存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實(shí)驗DMSO:100mg/mL(415.44mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM4.1544mL20.7719mL41.5438mL5mM0.8309mL4.1544mL8.3088mL10mM0.4154mL2.0772mL4.1544mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性Antibacterialagent117，三唑衍?物，?種抗劑。Antibacterialagent117對R.prowazekiiMetAP1(RpMetAP1)有抑制作?，其IC50值為15μM。Antibacterialagent117也可抑制?克次體?長，可?于感染的研究。IC50&TargetIC50:15μM(RpMetAP1)[1]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體外研究Antibacterialagent117caninhibitRpMetAP1withanIC50valueof15μM[1].Antibacterialagent117(0.3μM,3μM,30μMand300μM)stimulatesendothelialcell(EC)metabolismandalsoinhibitsrickettsialgrowth[1].REFERENCES[1].TravisRHelgren,etal.Rickettsiaprowazekiimethionineaminopeptidaseasapromisingtargetforthedevelopmentofantibacterialagents.BioorgMedChemMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02