Neomycin-sulfate-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENeomycinsulfateCat.No.:HY-B0470CASNo.:1405-10-3分?式:C??H??N?O??S?分?量:908.88作?靶點:Bacterial;Antibiotic;Phospholipase作?通路:Anti-infection;MetabolicEnzyme/Protease儲存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實驗H2O:250mg/mL(275.06mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.1003mL5.5013mL11.0026mL5mM0.2201mL1.1003mL2.2005mL10mM0.1100mL0.5501mL1.1003mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：PBSSolubility:50mg/mL(55.01mM);Clearsolution;Needultrasonic1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性Neomycinsulfate?種氨糖苷類抗?素，通過核30S核糖體亞單位的不可逆結合發(fā)揮抗活性(antibacterial)，從?阻斷細蛋?質(zhì)的合成。Neomycinsulfate?種已知的磷脂酶C(PLC)抑制劑。Neomycinsulfate能抑制?管?成素的核轉(zhuǎn)位和?管?成素誘導的細胞增殖和?管?成。IC50&TargetAminoglycoside體外研究Neomyciniseffectiveagainstmostgram-negativeorganismsexceptPseudomonasaeruginosaandanaerobicbacteria.Itsactivityagainstgram-positivemicroorganismsismoreorlesslimitedtostaphylococci,butbacterialresistancesupervenesafterprolongeduse[1].戶使?本產(chǎn)品發(fā)表的科研?獻?EmergMicrobesInfect.2022Feb22;1-34.?BrainBehavImmun.2020Nov24;S0889-1591(20)32408-9.?CellRep.2021Sep7;36(10):109660.?CellDeathDis.2021Jun7;12(6):582.?CellDeathDiscov.2022Feb22;8(1):77.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SassevilleD.Neomycin.Dermatitis.2010;21(1):3-7.[2].HuGF.Neomycininhibitsangiogenin-inducedangiogenesis.ProcNatlAcadSciUSA.1998;95(17):9791-9795.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: