SMCC-DM1-DM1-SMCC-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESMCC-DM1Cat.No.:HY-101070CASNo.:1228105-51-8Synonyms:DM1-SMCC分?式:C??H??ClN?O??S分?量:1072.61作?靶點(diǎn):Drug-LinkerConjugatesforADC作?通路:Antibody-drugConjugate/ADCRelated儲(chǔ)存?式:-80°C,storedundernitrogen溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:16.67mg/mL(15.54mM;ultrasonicandwarmingandheatto80°C)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM0.9323mL4.6615mL9.3231mL5mM0.1865mL0.9323mL1.8646mL10mM0.0932mL0.4662mL0.9323mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months(storedundernitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:2mg/mL(1.86mM);Clearsolution;Needultrasonic2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2mg/mL(1.86mM);Clearsolution;Needultrasonic1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2mg/mL(1.86mM);ClearsolutionBIOLOGICALACTIVITY?物活性SMCC-DM1(DM1-SMCC)由linkerSMCC和毒性分?DM1連接?成的，可?來制備抗體偶聯(lián)藥物。DM1(Mertansine)，含硫醇的美登?素?物堿，?種有效的微管破壞劑[1]。IC50&TargetMaytansinoids體外研究SMCC-DM1inhibitsHCC1954andMDA-MB-468cellsproliferationwithIC50sof17.2and49.9nM,respectively[1].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?MolTher.2022Apr18;S1525-0016(22)00237-4.?CancerLett.2022:216024.?Mbio.2022Jan18;e0338421.?IntJMolSci.2022,23(20),12358.?MonoclonAntibImmunodiagnImmunother.2020Apr;39(2):37-44.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].ShaoS,etal.Site-specificandhydrophilicADCsthroughdisulfide-bridgedlinkerandbranchedPEG.BioorgMedChemLett.2018May1;28(8):1363-1370.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-