S-R-S-AHPC-PEG4-NH2-VH032-PEG4-NH2-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(S,R,S)-AHPC-PEG4-NH2Cat.No.:HY-103604ACASNo.:2010159-57-4Synonyms:VH032-PEG4-NH2;VHLLigand-LinkerConjugates4;E3ligaseLigand-LinkerConjugates7FreeBase分?式:C??H??N?O?S分?量:663.83作?靶點(diǎn):E3LigaseLigand-LinkerConjugates作?通路:PROTAC儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:170mg/mL(256.09mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.5064mL7.5320mL15.0641mL5mM0.3013mL1.5064mL3.0128mL10mM0.1506mL0.7532mL1.5064mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性(S,R,S)-AHPC-PEG4-NH2?種合成的E3連接酶配體-linker偶聯(lián)物，包含于(S,R,S)-AHPC的VHL配體和4個(gè)單元PEGlinker。1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEIC50&TargetVHL體外研究E3ligaseLigand-LinkerConjugates7FreeBase,extractedfrompatentUS20170008904A1,canbeusedinthesynthesisofcompoundA1895inexample3[1].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?BioconjugChem.2020Nov18;31(11):2564-2575.?ACSOmega.2020Dec28.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].Crew,AndrewP,etal.MDM2-BASEDMODULATORSOFPROTEOLYSISANDASSOCIATEDMETHODSOFUSE.US20170008904A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:0