Ceftobiprole-medocaril-sodium-BAL5788-sodium-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECeftobiprolemedocarilsodiumCat.No.:HY-106574ACASNo.:252188-71-9Synonyms:BAL5788sodium分?式:C??H??N?NaO??S?分?量:712.64作?靶點(diǎn):Bacterial作?通路:Anti-infection儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:250mg/mL(350.81mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.4032mL7.0162mL14.0323mL5mM0.2806mL1.4032mL2.8065mL10mM0.1403mL0.7016mL1.4032mLBIOLOGICALACTIVITY?物活性Ceftobiprolemedocaril(BAL5788)sodiumCeftobiprole(HY-112579)的胃腸外前藥。Ceftobiprole?種?腸道吡咯烷酮頭孢素。Ceftobiprole?種?譜頭孢素，對(duì)甲氧西林(MRSA)和耐萬(wàn)古霉素葡萄球(VRSA)和耐霉素鏈球具有??平的體外活性。Ceftobiprole也抑制?蘭?陽(yáng)性和?蘭?性病原體。體內(nèi)研究Ceftobiprolemedocaril(s.c.;3×q12h;totaldailydosesofBAL9141equivalents,2.1,4.2,or8.4mg/kg)causesten-daycumulativesurvivalratesrangedfrom57to100%forfemaleSwissalbinomice(bodyweight,20to22g)infectedPenrCrosCtxsstrainP-15986[1].Ceftobiprolemedocaril(10,40,160mg/kg;singledose;sc)hasT1/2sfrom20minto31min,asthedoserosefrom40mg/kgto160mg/kg.TheAUC/dosevaluesfortheescalatingsingledosesrangesfrom0.585to1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE1.33,andtheCmax/dosevaluesdecreasesfrom1.08to0.90inneutropenicthigh-infectedmice[2].REFERENCES[1].EAzoulay-Dupuis,etal.EfficacyofBAL5788,aprodrugofcephalosporinBAL9141,inamousemodelofacutepneumococcalpneumonia.AntimicrobAgentsChemother.2004Apr;48(4):1105-11.[2].WACraig,etal.Invivopharmacodynamicsofceftobiproleagainstmultiplebacterialpathogensinmurinethighandlunginfectionmodels.AntimicrobAgentsChemother.2008Oct;52(10):3492-6.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379