聚六亞甲基雙胍鹽酸鹽polyhexamethylenebiguanidineh

Title:精品文檔放心下載感謝閱讀DocumentTypeNumber:UnitedStatesPatentApplicationCode:A1精品文檔放心下載Abstract:Theinventionisanactiveingredientbinationprisingpolyhexamethylenebiguanidinehydrochloridedistearyldimethylammoniumchlorideandacosmeticordermatological

formulationprisingpolyhexamethylenebiguanidinehydrochlorideand

distearyldimethylammoniumchloride.Theinventionalsoincludesmethods

offightingorpreventingdermatologicalharmprisingapplyingtotheskin

acosmeticdermatologicalformulationprisingpolyhexamethylene

biguanidinehydrochlorideanddistearyldimethylammoniumchloride.The

inventionalsoincludesmethodsofpreventingdecayoforganicsubstances

inaformulation,prisingaddingtoformulationpolyhexamethylene

biguanidinehydrochlorideanddistearyidimethylammoniumchloride.感謝閱讀謝謝閱讀感謝閱讀AdsGoogleGlycidylmethacrylateMethacrylicacidoracrylicacidwithavarietyofdifferentalcohol精品文檔放心下載.nofamerica.AntibioticResistanceProtectionAgainstCatheter-RelatedBloodstreamInfections.ReadMore..精品文檔放心下載.cookmedical.8MGuanidineSolutionHighpurity8MGuanidine-HClforproteinsolubilization&refolding.感謝閱讀.piercenet.LotrylResinsArkemamanufacturesLotrylResinsEBAandEMAcopolymers精品文檔放心下載.arkema-inc.StaphAureusCountsReduceStaphAureusCounts,WipersImproveIPAContactTimes.

SeeHow!謝謝閱讀.Foamtecintlwcc.Inventors:Kroepke,Rainer(Schenefeld,DE)

Zelle,Dagmar(Bliedersdorf,DE)感謝閱讀Filbry,Alexander(Hamburg,DE)

Hamer,Gunhild(Hamburg,DE)謝謝閱讀精品文檔放心下載PlaqueIt!ApplicationNumber:11/090693PublicationDate:01/26/2006FilingDate:03/25/2005PatentImages:ImagesavailableinPDFformwhenloggedin.ToPDFs,

LoginCreateAccount(Free!)感謝閱讀謝謝閱讀ExportCitation:Clickforautomaticbibliographygeneration

Assignee:謝謝閱讀BeiersdorfAGPrimaryClass:424/78.270OtherClasses:424/59,514/635,514/643InternationalClasses:謝謝閱讀A61K7/42;A61K31/155;A61K31/14Attorney,AgentorFirm:精品文檔放心下載ALSTON&BIRDLLP;BANKOFAMERICAPLAZA(101SOUTHTRYONSTREET,SUITE4000,

CHARLOTTE,NC,28280-4000,US)謝謝閱讀Thatwhichisclaimed:1.Anactiveagentbination,prisingpolyhexamethylenebiguanidinehydrochloridedistearyldimethylammoniumchloride.2.Acosmeticdermatological

formulation,prisingpolyhexamethylenebiguanidinehydrochlorideand

distearyldimethylammoniumchloride.3.Thecosmeticordermatological

formulationasclaimedinclaim2,furtherprisingatleastoneantioxidant.ThecosmeticdermatologicalformulationclaimedinclaimfurtherprisingatleastUVfiltersubstance.Thecosmetic感謝閱讀ordermatologicalformulationasclaimedinclaim2,whereinformulationisintheformofanemulsion.6.Thecosmeticordermatological

formulationasclaimedinclaim2,whereinsaidformulationisintheformofan

oil-in-wateremulsion.7.Thecosmetic精品文檔放心下載ordermatologicalformulationasclaimedinclaim2,whereinsaid

formulationisintheformofawater-in-oilemulsion.8.Thecosmeticor

dermatologicalformulationasclaimedinclaim2,from0.01

to20%byweightintotalofthebinationofpolyhexamethylenebiguanidine

hydrochlorideanddistearyldimethylammoniumchloride,basedonthetotal謝謝閱讀感謝閱讀weighttheformulation.Thecosmeticdermatologicalformulation

asclaimedinclaim8,prisingfrom0.02to5%byweightintotalthe

binationofpolyhexamethylenebiguanidinehydrochlorideand

distearyidimethylammoniumchloride,basedonthetotalweightofthe

formulation.10.Thecosmeticordermatologicalformulationasclaimed

inclaim9,prisingfrom0.05to3%byweightintotalofthebination

ofpolyhexamethylenebiguanidinehydrochlorideand感謝閱讀感謝閱讀謝謝閱讀精品文檔放心下載精品文檔放心下載感謝閱讀精品文檔放心下載distearyidimethylammoniumchloride,basedonthetotalweightoftheformulation.11.Amethodofpreventingthegrowthofbacteria,mycobionts,viruses,prisingapplyinganactiveagentbinationprisingpolyhexamethylene

biguanidinehydrochlorideanddistearyldimethylammoniumchloride.12.A

methodoffightingpreventingdermatologicalharm,prisingapplyingtotheskin

acosmeticordermatologicalformulationprisingpolyhexamethylenebiguanidine

hydrochlorideanddistearyldimethylammoniumchloride.13.Themethodclaimedinclaimformulationprisesfrom0.01to20%byweightin

totalofthebinationpolyhexamethylenebiguanidinehydrochlorideand

distearyldimethylammoniumchloride,basedonthetotalweighttheformulation.14.Themethodclaimedinclaim12,whereinsaid

formulationprisesfrom0.02toweightintotalthebinationofpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammonium

chloride,basedonthetotalweightoftheformulation.Themethodasclaimed

inclaimwhereinsaidformulationprisesfrom0.05tobyweightintotalof

thebinationofpolyhexamethylenebiguanidinehydrochloridedistearyldimethylammoniumchloride,basedonthetotalweightoftheformulation.Themethodclaimedinclaimforpreventingimprovingneurodermatitis.17.Themethodasclaimedinclaimforpreventing

thegrowthoforStaphylococcusaureus.Aofpreventingdecayof

organicsubstancesinaformulation,prisingaddingtosaidformulationpolyhexamethylenebiguanidinehydrochlorideand

distearyldimethylammoniumchloride.19.Themethodasclaimedinclaimwhereinsaidformulationprisesfrom0.01toweightintotal

ofthebinationofpolyhexamethylenebiguanidinehydrochlorideand

distearyldimethylammoniumchloride,basedonthetotalweightofthe

formulation.20.Themethodasclaimedinclaimwhereinsaid

formulationprisesfrom0.02toweightintotalofthebinationof

polyhexamethylenebiguanidinehydrochloride謝謝閱讀感謝閱讀謝謝閱讀精品文檔放心下載感謝閱讀謝謝閱讀distearyldimethylammoniumchloride,basedonthetotalweightofthe

formulation.21.Themethodasclaimedinclaimwhereinsaid

formulationprisesfrom0.05toweightintotalofthebinationof

polyhexamethylenebiguanidinehydrochloride謝謝閱讀感謝閱讀感謝閱讀distearyldimethylammoniumchloride,basedonthetotalweightofthe

formulation.精品文檔放心下載Description:CROSS-REFERENCETORELATED

APPLICATIONS精品文檔放心下載ThisisacontinuationapplicationofPCT/EP02/10817,filedSep.26,2002,

whichclaimsthebenefitofDE47186.6,filedSep.2001.精品文檔放心下載精品文檔放心下載FIELDOFTHEINVENTIONThepresentinventionconcernsactiveingredientbinationsprising

polyhexamethylenebiguanidinehydrochloridedistearyidimethylammonium

aswellastheuseofactiveingredientbinationsasagentsagainstbacteria,

mycotaviruses,inparticularforpreservingcosmeticanddermatologicalemulsions.Inparticular

embodiments,thepresentinventionconcernspreparations,preferably

cosmeticanddermatologicalpreparationscontainingsuchsubstances.精品文檔放心下載BACKGROUNDOFTHEINVENTION精品文檔放心下載Healthywarm-bloodedorganisms,inparticularhealthyhumanskin,are

colonizedawidevarietyofnonpathogenicmicroorganisms.These

so-calledmicrofloraoftheskinarenotonlyharmless,butalsorepresentan

importantformofprotectionasadefenseagainstopportunisticpathogenicmicrobes.感謝閱讀精品文檔放心下載Bacteriabelongtotheprokaryoticsingle-celledorganisms.Theycanbe

crudelydistinguishedaccordingtotheirshape(ball,cylinder,cylinder)as

asthestructuretheirwall(gram-positive,gram-negative).The

physiologytheorganismsalsoallowsforfinerdistinctions.Therethusexistaerobic,anaerobicandfacultativelyanaerobic

bacteria.individualsareofsignificanceowingtotheir

characteristicaspathogenicmicrobes,whileothersarepletely

harmless.感謝閱讀Substanceseffectiveagainstbacteriahavebeenknownforsometimenow.

Nevertheless,manytheseantibacterialagentsaresuitableforall

medical,letalonecosmetic,applications,themetabolicfunctionsofthewarm-

bloodedorganism,inotherwordsthediseasedpatient,arealso

affectedbytheapplicationinwayanother.感謝閱讀謝謝閱讀感謝閱讀Gram-negativemicrobesaretypicallyEscherichiacoli,Pseudomonas

specieswellenterobacteriasuchasCitrobacterfreundii.感謝閱讀Evengram-positivemicrobesplayaroleincosmeticsanddermatology.Thus,

forexample,bacterialsecondaryinfectionsarealsoofetiologicalsignificance

besidesotherinfluences.Oneofthemostimportant謝謝閱讀microorganismsassociatedwithuncleanskinisStaphylococcusaureus.

ThisisresponsibleforthesymptomsImpetigofollicularis,furunculosis,abscesses,

sepsis,pemphigusneonatorum,toxicshocksyndrome,foodpoisoningetc.In

additiontothis,examinationshaverevealedthatahighpercentage(overof

thoseaffected)ofneurodermatitisexhibitedinpart,extremelycontentofStaphylococcusaureus

ontheskin.謝謝閱讀Incontrasttobacteria,fungi(alsoreferredtomycotaormycobionts)

belongtotheeukaryotes.Incontrasttotheso-calledprokaryotes(procytes),

eukaryotesarelivingorganismswhosecells(eucytes)have

acellnucleusseparatedfromtheremainingcytoplasmbyanuclearenvelope

nuclearmembrane.Thenucleuscontainsthegeneticinformation

storedinchromosomes.謝謝閱讀Typicalrepresentativesofthemycobiontsincludeyeasts

(Protoasycetes),(Plectomycetes),(Pyrenomycetes),

falsemildews(Phyycetes)andmushroomsortoadstools

(Basidiomycetes).感謝閱讀FungibelongtothePlantKingdom,butlikeplantshaveacellwallaswellas

vacuolesfilledcellsapandplasmastreamingclearlyvisiblemicroscopically.Theycontainanyphotosyntheticpigmentsare

C-heterotroph.Theygrowunderaerobicconditionsandobtainenergythrough

oxidationoforganicsubstances.Severalrepresentatives,forexampleyeasts,arefacultativeanaerobescapableofobtainingenergy

throughfermentationprocesses.謝謝閱讀Dermatomycosesdiseasesinwhichcertainspeciesoffungi,in

particulardermatophytes,penetratetheskinhairfollicles.Typical

symptomsofdermatomycosesarevesicles,exfoliation,fissureserosion,usuallyacpanieditchingorallergiceczema.感謝閱讀謝謝閱讀謝謝閱讀謝謝閱讀DermatomycosescanessentiallydividedintofourDermatophyes

(e.g.epidermophytosis,favus,microsporosis,trichophytosis),yeastmycoses

(e.g.pityriasisothermycosescausedbypityrospores,Candidainfections,blastomycosis,Busse-Buschkedisease,torulosis,piedra

alba,torulopsosis,trichosporosis),mouldmycoses(e.g.aspergilosis,cephalosporiosis,ndscopulariopsis)謝謝閱讀systemmycoses(e.g.chromomycosis,coccidiomycosis(Posada'sdisease)

orhistoplasmosis).精品文檔放心下載ThepathogenicmicrobestypicallyincludeCandidaspeciesfromtheyeast

group(e.g.Candidaalbicans)thosethePityrosporumfamily.

Pityrosporumspecies,inparticularPityrosporumovale,areresponsible

forskindiseasessuchasPityriasisversicolor,Seborrhentheforms

SeborrheaoleosaSeborrheasiccawhichprimarilymanifestedSeborrheacapitis(dandruff),seborrheiceczemaandPityrosporum

folliculitis.AninvolvementofPityrosporumovalethedevelopmentof

psoriasisiscurrentlyunderdiscussioninthemedicalworld.感謝閱讀Allregionsofthehumanskinaffectedbydermatomycoses.謝謝閱讀Dermatophytesalmostexclusivelyattacktheskin,andnails.Yeastmycosesregularlyextendtotheentireorgansystems.謝謝閱讀感謝閱讀Thoseareastheskininwhichhumidityandwarmthcanaccumulateon

accountofclothing,jewelryorshoesaffectedparticularly

frequently.Athlete'sfootrepresentsoneofthemostfamiliarwidespreadthese.Fungaldiseasesnailareasoftheandfootarealso

particularlyunpleasant.感謝閱讀Moreover,super-infectionsoftheskinfungiandbacteriaareunmon.精品文檔放心下載Ifaprimaryinfectionisextant,i.e.ifainfectionoccurswitha

highnumberofmicrobesforoneorseveralpathogens(forexample

staphylococci—oftenhowevernonpathogenicexampleCandida

albicans),“super-infection”oftheaffectedskinoccurif

unfavorableinfluencescoincide.Thenormalmicrofloraoftheskinanotherorganofthebody)areoverwhelmedthesecondarypathogensin

this謝謝閱讀謝謝閱讀謝謝閱讀精品文檔放心下載Dependingonthemicrobeconcerned—suchsuper-infectionsmanifestedinfavorablecasesasunpleasantskinappearances(itching,

unattractiveexternalappearance).Inunfavorablecases,however,they

canleadtolarge-scaledestructionoftheskin,intheworstsituation

thedeathofthepatient.謝謝閱讀謝謝閱讀謝謝閱讀精品文檔放心下載謝謝閱讀Suchsuper-infectionsareobservedforawidevarietyofdermatological

diseases,forexampleeczema,neurodermitis,seborrheicdermatitis

orpsoriasis.Evenmanymedicalandtherapeuticmeasures,e.g.radiography

orchemotherapyfortumordiseases,medicinally-induced謝謝閱讀謝謝閱讀immunosuppressioncausedasaside-effectorsystemictreatmentantibiotics,asasexternalchemicalorphysicalinfluences(e.g.謝謝閱讀environmentalpollution,smog),promotetheoccurrenceof謝謝閱讀super-infectionsoftheexternalandinternalorgans,inparticulartheskinandthemucousmembrane.精品文檔放心下載精品文檔放心下載Althoughitisperfectlypossibletofightsuper-infectionsantibiotics,such

substancesusuallyhavethedisadvantageunpleasanteffects.Patientsareoftenallergictopenicillinforexample,asresultofwhich

acorrespondingtreatmentwouldberuledoutinsuchcases.感謝閱讀Moreover,topicallyadministeredantibioticsthedrawbackofonly

removingsecondarypathogensfromtheskin,alsohaveadverse

effectonthepurelyphysiologicalskinflora,withtheresultthatthenatural

healingprocessissloweddownagain.精品文檔放心下載Theaimofthepresentinventionwastoremedythedisadvantagetheprior

artprovidesubstancesandpreparationscontainingsuchsubstancesthroughtheusewhichsuper-infectionsancured,wherebythe

physiologicalskinfloradoesnotsufferanysignificantsideeffects.精品文檔放心下載Incontrasttotheprokaryoticandeukaryoticcellularorganisms,viruses

representbiologicalstructureswhichrequireahostcellforbiosynthesis.

Extracellularviruses(alsoreferredtoa“virions”)感謝閱讀consistasingledoublestrandednucleicacidsequence(DNSRNS)anda

proteinmantle(calledthecapsid),sometimessurroundedbyanadditional

envelopecontaininglipids.Theentirestructureprising感謝閱讀nucleicacidandcapsidisreferredtothenucleocapsid.Viruseswere

originallyclassifiedaccordingtotraditionalandclinicalcriteria,butnowadaysthey

aregenerallyclassifiedaccordingtotheirstructure,morphologyand,inparticular,thenucleicacidsequence.謝謝閱讀Medicallyimportantvirusgeneraaretypicallyinfluenzaviruses(the

Orthomyxoviridaefamily),(e.g.rabies,Rhabdovirusfamily),

(e.g.Hepatitis-A,Picornaviridaefamily),Hepadnaviruses

(Hepatitis-B,Hepadnavirusfamily).精品文檔放心下載精品文檔放心下載Virucides,i.e.,substancescapableofkillingvirusesdoactually

existinthestrictsensetheterm,asvirusesdohavetheirown

metabolism.Pharmacologicalinterventionswithoutdamagetothethatare

affectedare,however,difficult.Possiblemechanisms感謝閱讀精品文檔放心下載actioninthefightagainstvirusesareprimarilythedestructionoftheir

replication,e.g.,blockingtheenzymesinthehostcellimportantfortheir

replication.Furthermore,thereleaseofviralnucleicacidsintothehostcan

beprevented.Withinthescopethedisclosurepresentedhere,theterms“antiviral”or“effectiveagainstviruses”,

“virucide”similarrefertothepropertyasubstanceenablingit謝謝閱讀toprotectasingleormulti-cellularorganismagainsttheharmfuleffects

ofaviralinfection,beitprophylacticortherapeutic,regardlesswhatthe

actualmechanismactionthesubstanceinindividualcases

is.謝謝閱讀精品文檔放心下載Substanceseffectiveagainstviruseswhichdonotdamagethehostorganism,

ordosotounjustifiabledegree,areinthepriorart.精品文檔放心下載Afurtheroftheinventionthereforetofindsubstances

whicheffectivelyprotectasingle-celledmulti-cellularorganismagainstthe

detrimentaleffectsaviralinfection,itprophylactic

ortherapeutic.謝謝閱讀Preservativesantimicrobialsubstanceswhichaddedtoaproduct

(foodandluxuryitems,pharmaceutical,cosmeticoralso感謝閱讀精品文檔放心下載chemical-technicalpreparations)duringtheproductionprocessinsmall

amounts(usuallybetweenapprox.0.0005%and1%activecontent,dependingon

theproduct).Preservativesareintendedtoprotectproductsfrom

contaminationmicroorganisms,inparticularfromdetrimentalchanges

causedmicrobes,duringproduction,storageandconsumption.精品文檔放心下載Thefollowingrequirementsareessentiallydemandedofapreservative:

Itmustbesufficientlyantimicrobial,aswellascapableofbeingappliedtechnically

safelyinrespecttohealth.Thefinishedpreparation—themercial—

beharmlesstohealth.itisnecessarytoconsiderthat

microorganisms,e.g.,incosmeticpreparations,canbepresentprimarilyasaresultofproductionorcanenterthe

cosmeticpreparationsecondarilyonaccountoftheconsumer.精品文檔放心下載Itmustthereforeensuredthatthefinishedisalsosafethroughouttheentireperiodconsumption.精品文檔放心下載謝謝閱讀Preservativesauthorizedinfoodtechnology—suchthoselistedinthe

followingtable—canalsoeffectivelyfortheproductionpharmaceuticalorcosmeticproducts.感謝閱讀感謝閱讀精品文檔放心下載E200SorbicacidE201Sodiumsorbate

E202Potassiumsorbate

E203CalciumsorbateE210BenzoicacidE211SodiumbenzoateE212Potassiumbenzoate

E213CalciumbenzoateE214Ethylp-hydroxybenzoate感謝閱讀E215Sodiumethylp-hydroxybenzoate謝謝閱讀E216Propylp-hydroxybenzoate感謝閱讀E217Sodiumpropylp-hydroxybenzoate精品文檔放心下載E218Methylp-hydroxybenzoate謝謝閱讀E219Sodiummethylp-hydroxybenzoate

E220Sulfurdioxide謝謝閱讀E221SodiumsulfiteE222Sodiumhydrogensulfite

E223Sodiummetabisulfite

E224Potassiummetabisulphite

E226Calciumsulfite精品文檔放心下載謝謝閱讀E227Calciumhydrogensulfite謝謝閱讀E228Potassiumhydrogensulfite

E230Biphynel(Diphenyl)

E231Orthophenylphenol

E232Sodiumorthophenylphenyl

E233Thiabendazole感謝閱讀感謝閱讀E235NatamycinE236FormicacidE237Sodiumformate

E238Calciumformate

E239Hexamethylenetetramine

E249Potassiumnitrite

E250Sodiumnitrite謝謝閱讀E251SodiumnitrateE252Potassiumnitrate

E280PropionicE281Sodiumpropionate

E281Calciumpropionate

E283Patassiumpropionate

E290CarbondioxideThefollowingalsorepresentpreservativespreservativeadditives

monlyusedinthecosmeticsindustry:Dibromodicyanobutane

(2-bromo-brommethylglutarodinitrile),3-iodo-2-propynylbutylcarbamate,

2-bromo-2-nitro-propane-1,3-diol,imidazolidinylurea,

5-chloro-2-methyl-4-isothiazolin-3-on,2-chloracetamide,benzalkonium

chloride,benzylalcohol.感謝閱讀謝謝閱讀精品文檔放心下載精品文檔放心下載Inadditiontothis,phenylhydroxyalkylethers,inparticularthepound

familiarunderthedesignationphenoxyethanol,wereusedaspreservativesaccountoftheirbactericidalandfungicidaleffectsonanumberofmicro-

organisms.謝謝閱讀Polyhexamethylenebiguanidinehydrochlorideisalsofamiliarinitself

asapreservativeforO/WW/Oemulsions.Polyhexamethylene

biguanidinehydrochloridewiththeCTFAdesignation“Polyaminopropyl

Biguanide”(CASNO.28757-47-3)isdistinguishedthefollowingformula:謝謝閱讀謝謝閱讀isavailablefromZenecaBiocidesunderthetradenameARLAGARD?E.感謝閱讀ARLAGARD?Eisacolorlesstoyellowish,odorless,cationicsolutionawideantimicrobialspectrum(effectiveagainst

gram-positivegram-negativebacteriaasyeastsfungi).精品文檔放心下載Mostpreservativesproposedorenvisagedforpreservationhavea

bacteriostaticandfungistaticeffect,occasionallyalsobactericidalandfungicidal.

Theyshouldbeodorlessandtastelessand,ifpossible,精品文檔放心下載soluble,non-toxic,skin-patiblesufficientlyeffectiveinthedoseapplied.精品文檔放心下載Inordertobeeffective,thepreservativesmustbedissolvedraw

materialorauxiliaryagenttopreserved.Asmostpreservativesaremorefat-

solublethanwater-soluble,itmustbeconsideredthat,for精品文檔放心下載example,inanemulsionwhoseaqueousphaseistobepreserved,the

preservativeincorporatedintheaqueousphasemigratestothefatphaseduring

thecourseofstorage,andhencecallsquestionthepreservationthe

aqueousphase.Thisposesaproblemforthepreservationofoil-in-water

formulationsinparticular.謝謝閱讀Althoughnosterilityisgenerallyrequiredforacosmeticpreparation,

itmustfreepathogenicmicrobesandprotectedagainstmicrobially

inducedchanges.精品文檔放心下載Itisimportanttoconsiderthatthevariousemulsiontypes,aqueous

solutions,suspensionsetc.requireadifferentpreservation,thatthepreservative

effectofindividualpreservativesdependsontheposition謝謝閱讀thephysicalpropertiesofthepreparationtobepreserved,that

interactionsbetweenthepreservative,theactiveagentandtheauxiliaryagentsare

tobeexpected,thatactiveauxiliarycan精品文檔放心下載adsorbandhencepotentiallyinactivatepreservatives,thatinparticular

hydrocolloidscontainedinthepreparationcanimpedepreservativesintheir

antimicrobialactivity,dependingontheconcentration,andfinallythat—dependingtheconcentrationandtypeofstratumcorneumadsorbsthepreservative,withtheresultthatpermeationand

absorptionofthepreservativethenoccur.精品文檔放心下載SUMMARYOFTHEINVENTIONItsurprisinglydiscovered,hereinliesthesolutiontotheseobjectives,

thatactiveagentbinationsprisingpolyhexamethylenebiguanidinehydrochlorideanddistearyldimethylammoniumchlorideaswellasthe

useofsuchactiveagentbinationsasantibacterial,antimycotic

orantiviralagentsremediesthepriorart.謝謝閱讀Theactiveagentbinationsaccordingtotheinventionastonishinglyactina

synergisticmanner,i.e.,withanoveradditiveeffectinrelationtotheindividualponents.Thiswastoexpectedinparticularonaccountof

thefactthatdistearyldimethylammoniumchlorideitselfexhibitsnoantimicrobialeffect.感謝閱讀Theactiveagentbinationsaccordingtotheinventionalsomakesubstances

availablewhichareeffectiveagainstgram-positiveand/orgram-negativebacteria

withoutentailinguntenableeffectthetheuser.精品文檔放心下載Distearyidimethylammoniumchloride(also:dimethyldioctadecylammoniumchloride,withtheCTFAdesignation“DistearyidimoniumChloride”isaquaternaryammoniumsaltwhichisbythefollowingstructuralformula:精品文檔放心下載感謝閱讀Especiallyadvantageousistheuseoftheactiveagentbinationsaccording

totheinventionapreservationsystemforcosmeticdermatological

oil-in-waterformulations,inparticularforcosmeticdermatological

O/Wemulsions.謝謝閱讀精品文檔放心下載謝謝閱讀Itsurprisinglybeenrevealedthattheactiveagentbinationsused

accordingtotheinvention—anoveradditivemannertobe

precise—preventthegrowthofgram-positiveandgram-negativebacteria,

mycobiontsandviruses.謝謝閱讀謝謝閱讀感謝閱讀Inparticular,theactivebinationsusedaccordingtotheinvention

arecapableofpreventingtheofgram-positivebacteria,

especiallythestaphylococcusspecies,namelyStaphylococcusareus.感謝閱讀精品文檔放心下載Moreover,itwasastoundingthattheactiveagentbinationsusedaccordingtothe

inventionareparticularlyeffectiveagainstneurodermatitisandthattheypreventthedevelopmentoftypicalrecurrencesofneurodermatitis.A

preferredembodimentofthepresentinventionthereforerepresentedbytheformulationstobeusedagainstneurodermatitis.感謝閱讀Finally,itbeenrevealedthattheactiveagentbinationsaccordingtotheinventioncanthedecayorganicsubstances,

inparticularcosmeticdermatologicalpreparations,asaresultofattackby

gram-positivegram-negativebacteria,mycobiontsand

viruses,iftheyareaddedtothesepreparations.謝謝閱讀謝謝閱讀謝謝閱讀Correspondingtotheinventionisaprocessforfightingmycobionts

characterizedbythefactthattheactiveagentbinationsusedaccordingtothe

invention,ifpossibleinasuitablecosmeticordermatologicalcarrier,arebrought

contactwiththeareacontaminatedwithmycobionts;aswellasaprocessfortheprotectionorganicproductsagainst

attackbymycobionts,characterizedthefactthattheactive

agentbinationsusedaccordingtotheinventionareaddedtotheseproductsin

aneffectiveconcentration.感謝閱讀Thepriorartdidconsequentlyprovideanyreferencewhatsoever

concerningtheuseasanantimycoticmechanisminaccordancewiththe

invention.謝謝閱讀DETAILEDDESCRIPTIONOFTHEPREFERREDEMBODIMENTS感謝閱讀Correspondingtotheinvention,theactiveagentbinationsarepreferably

usedincosmeticdermatologicalpositionswithacontent0.0005to50.0weight%,inparticular0.01to20.0weight%inrelationtothetotalweightofthe

position.Advantageously,thepositionscontain0.02謝謝閱讀感謝閱讀weight%,preferably0.02to5.0weight%oftheactiveagentbinations

usedaccordingtotheinvention,whileespeciallypreferredis0.5to3.0weight%,

respectivelyinrelationtothetotalweightoftheposition.謝謝閱讀Theactiveagentbinationsusedaccordingtotheinventionincorporatedwithoutanydifficultyincurrentcosmeticordermatological謝謝閱讀謝謝閱讀formulations,preferablypumpsprays,aerosolssprays,cremes,ointments,

tinctures,lotions,careproducts(e.g.nailvarnish,varnish

remover,andnailbalsam)andsimilar.謝謝閱讀感謝閱讀精品文檔放心下載PreparationsextantasemulsionsaccordingtothepresentinventioncontainormoreO/Wemulsifiersaswellas,possibly,additionalco-emulsifiers.ShouldtheemulsionscontainadditionalO/Wemulsifierswhich

maybepresentinthepreparationbesidethedistearyldimethylammonium

chloride,these(oneormorepounds)can,forexample,beadvantageously

selectedfromthegroupofpolyethoxylatedand/orpolypropoxylatedemulsifiers.精品文檔放心下載Theco-emulsifierco-emulsifiersarepreferablyselectedfromthe

groupfattyalcoholswith14to22carbonatoms,inparticularfromthegroup

offatty16tocarbonatomssuchasstearyl謝謝閱讀alcohol,cetylalcohol,cetylstearylalcohol(cetearylalcohol).精品文檔放心下載Itisalsopossible,andpossiblyadvantageous,tobinetheactivebinationsaccordingtotheinventionwithactiveagents,forothersubstancesantimicrobial,antimycoticorantiviraleffects.謝謝閱讀Iftheactiveagentbinationscorrespondingtotheinventionareusedactiveagentsforthepreservationorganicmaterials,anotheror

severalotherpreservativesselectedfromthesubstanceswiththe

E-numbersE-200toE-299canadditionallybeusedadvantageouslyand/or

anotherseveralotherpreservativesselectedfromthesubstances

dibromodicyanobutane(2-bromo-brommethylglutarodinitrile),

phenoxyethanol,3-iodo-2-propynylbutylcarbamate,精品文檔放心下載精品文檔放心下載謝謝閱讀感謝閱讀2-bromo-2-nitro-propane-1.3-diol,imidazolidinylurea,感謝閱讀5-chloro-2-methyl-4-isothiazolin-3-on,2-chloracetamide,benzalkonium

chloride,benzylalcohol.謝謝閱讀Itisalbeitnotnecessary,tobufferthepositions.Arange

of4.5to7.5Itisespeciallypreferablytoselectthe

pHvalueinarangeof5.0to6.5.感謝閱讀感謝閱讀感謝閱讀Thecosmeticand/ordermatologicalformulationsaccordingtotheinvention

canbeposedusualandservethetreatmentofskinand/or

hairwithinthescopeadermatologicaltreatmentatreatmentwithin

thescopeofbodycarecosmetics.Theycanalso,however,beusedinmakeup

productsindecorativecosmetics.感謝閱讀Thecosmeticand/ordermatologicalformulationsaccordingtothe

inventionareappliedintheusualmethodforcosmeticsandskincare

products,i.e.theskinand/orinasufficientconcentration.感謝閱讀感謝閱讀謝謝閱讀Advantageousarethosecosmeticand/ordermatologicalpreparationswhichexistintheformofaprotectionagent.Preferably,these感謝閱讀additionallycontainatleastoneUVAfilterand/oratleastoneUVBfilter感謝閱讀atleastinorganicpigment.感謝閱讀精品文檔放心下載Cosmeticpreparationscorrespondingtotheinventionforprotectingtheskin

againstUVradiationcanexistinvariousforms,arenormallyused

forthesetypesofpreparations.Theycanthusrepresent,forexample,asolution,

anemulsionthetypewater-in-oil(W/O)orofthetypeoil-in-water(O/W),or

multipleemulsions,forexampleofthetypewater-in-oil-in-water(WIOiw),agel,

ahydrodispersion,asolidpenanaerosol.感謝閱讀Thecosmeticpreparationscorrespondingtotheinventioncancontain

cosmeticauxiliaryarenormallyusedinsuchpreparations,forexample

preservatives,bactericides,antioxidants,perfumes,謝謝閱讀anti-foamingagents,colorings,whichhaveacoloringeffect,

thickeningagents,surfactants,emulsifiers,plasticizingagents,moisturizing

moisteningagents,fats,oils,waxesandotherstandardponentsofaformulationsuchasalcohols,polymers,

foamstabilizers,electrolytes,organic