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閱讀實(shí)戰(zhàn)訓(xùn)練(三)★Whydida1promising有希望的,有前途的heartdrug2Doomed命中注定drughighlights3complications并發(fā)癥of4meddlingwith瞎弄;亂動(dòng)5cholesterol[k?'lest?r?l]膽固醇.Thefailureofa6high-profile備受矚目的cholesteroldrughasthrowna7spotlight聚光燈on8complicated復(fù)雜的9machinery機(jī)械;機(jī)器that10regulates調(diào)節(jié)cholesterollevels.Butmanyresearchersremainconfidentthatdrugsto11boost促進(jìn);增加levelsof'good'cholesterolarestilloneofthemostpromisingmeansto ;與…戰(zhàn)斗13spiralling原地打轉(zhuǎn)heartdisease. Pfizer14announced宣布o(jì)n2Decemberthatitwascancellingall15clinicaloftorcetrapib抑制劑,adrugdesignedtoraiseheart-protectivehigh-densitylipoproteins(HDLs).Inatrialof1500016patients ,asafety17board foundthatmorepeoplediedor cardiovascular[,kɑ?d???'v?skj?l?]心血管的problemsaftertakingthedrugplusacholesterol-loweringstatinthanthoseinacontrolgroupwhotookthestatinThenewscameasa18kickintheteeth責(zé)備,口頭指責(zé)批評(píng)tomanycardiologists心臟病專家becauseearliertestsinanimalsandpeoplesuggesteditwouldlowerratesofcardiovasculardisease."Therehavebeenno19redflags 信號(hào)tomyknowledge,"saysJohnChapman,a20specialist專家inlipoproteinsandatherosclerosisattheNationalInstituteforHealthandMedicalResearch(INSERM)inPariswhohasalsostudiedtorcetrapib."Thiscancellationcameasacompleteshock."Torcetrapibisoneofthemost21advanced先進(jìn)的ofa22newbreed新品種ofdrugsdesignedraiselevelsofHDLs,which23ferry擺渡cholesteroloutof24artery動(dòng)脈-25clogging阻塞26 ques斑塊tothe27liver肝臟forremovalfromthebody.Specifically,torcetrapib28blocks阻礙; 29protein蛋白質(zhì)calledcholesterolestertransferprotein(CETP),whichnormallytransfersthecholesterolfromhigh-densitylipoproteinstolowdensity,que-promotingones.Statins,incontrast,mainlyworkbyloweringthe'bad'low-densitylipoproteins.UnderResearchersarenowtryingtoworkoutwhyandhowthedrug30backfired適得其反,somethingthatwillnot eclearuntiltheclinicaldetailsare31released釋放byPfizer.One32hint暗示;線索liesinevidencefromearliertrialsthatit33slightly輕微地raisesbloodpressureinsomepatients.Itwasthoughtthatthis34mild溫和的;輕微的problemwouldbe35offset抵消,補(bǔ)償bytheheartbenefitsofthedrug.Butitispossiblethatitactuallyproved36fatal致命的;重大的insomepatientswhoalreadysufferedhighbloodpressure.Ifbloodpressureistheex nation,itwouldactuallybegoodnewsfordrugdevelopersbecauseitsuggeststhattheproblemsarespecifictothis pound化合物.Other38prototype原型;標(biāo)準(zhǔn)drugsthatarebeingdevelopedtoblockCETPworkinaslightlydifferentwayandmightnotsufferthesame39downfall ButitisalsopossiblethatthewholeideaofblockingCETPis40flawed有缺陷的;有瑕疵的saysMotiKashyap,whodirectsatherosclerosis動(dòng)脈硬化researchattheVAMedicalCenterinLongBeach,California.WhenHDLs41excrete排泄;分泌cholesterolintheliver,theyactuallyrelyonLDLsforpartofthisprocess.So42inhibiting抑制;約束CETP,whichpreventsthetransferofcholesterolfromHDLtoLDL,mightactuallycausean43abnormal反常的,不規(guī)則的and44irreversible45accumulation積累ofcholesterolinthebody."You'reblockinga46physiologic生理的;生47mechanism機(jī)制;原理to48eliminate剔除,清除cholesterolandeffectively49constipating使遲鈍thepathway,saysKashyap.GoingupMostresearchersremainconfidentthat50elevating使升高h(yuǎn)ighdensitylipoproteinslevelsbyonemeansoranotherisoneofthebest51routes路線forhel heartdiseasepatients.ButHDLsarecomplexandnotentirelyunderstood.One52approved被認(rèn)可的;經(jīng)過檢驗(yàn)的drug,calledniacin,isknowntobothraiseHDLandreducecardiovascularriskbutalsocausesanunpleasantsensationofheatand53tingling麻刺感.Researchersareexploringwhethertheycan54bypass繞開;忽視this55sideeffect副用andwhetherniacincanlowerdiseaseriskmorethanstatinsalone.Scientistsarealsoworkingonseveralothermeanstobumpuphigh-densitylipoproteinsby,forexample,introducing56synthetic綜合的HDLs."Theonlythingweknowisdeadinthewateristorcetrapib,notthewholeideaofraisingHDL,"saysMichaelMiller,directorofpreventivecardiologyattheUniversityofMarylandMedicalCenter,(613wordsQuestions1-Thispassagehas7paragraphs1-Choosethecorrectheadingforeachparagraphfromthelistofheadingsbelow.Writethecorrectnumberi-ixinboxes1-7onyouranswersheet.ListofHowdoestorcetrapibContradictoryresultpriortothecurrentOnefailuremaypossiblybringaboutfutureThefailuredoesn’tleadtototallossofItistherightroutetoWhyit’sTheymaycombineandtheoreticallyproduceidealWhat’swrongwiththeItmightbewrongatthefirst ExampleanswerParagraph1ParagraphParagraphParagraphParagraphParagraphParagraphQuestions7-Matchtorcetrapib,HDLs,statinandCETPwiththeirfunctions(Questions8-13)..WritethecorrectletterA,B,CorDinboxes8-13onyouranswersheet.NBYoumayuseanylettermorethanIthasbeenadministeredtoover10,000subjectsina
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