外周神經(jīng)系統(tǒng)藥物(定)總結(jié)課件

脊髓的反射功能和反射弧第三章傳出《運(yùn)動)神經(jīng)效應(yīng)器外周神經(jīng)系統(tǒng)藥物感受器傳入神經(jīng)交感神經(jīng)外周神經(jīng)植物神經(jīng)系統(tǒng)傳出神經(jīng)(自主神經(jīng)系統(tǒng)副交感神經(jīng)運(yùn)動神經(jīng)系統(tǒng)外周神經(jīng)系統(tǒng)藥物(定)總結(jié)脊髓的反射功能和反射弧第三章傳出《運(yùn)動)神經(jīng)效應(yīng)器外周神經(jīng)系統(tǒng)藥物感受器傳入神經(jīng)交感神經(jīng)外周神經(jīng)植物神經(jīng)系統(tǒng)傳出神經(jīng)(自主神經(jīng)系統(tǒng)副交感神經(jīng)運(yùn)動神經(jīng)系統(tǒng)傳出神經(jīng)系統(tǒng)自主神經(jīng)運(yùn)動神經(jīng)CNS乙酰膽堿N膽堿受體無神經(jīng)節(jié)神經(jīng)遞質(zhì)乙酰膽堿神經(jīng)節(jié)N膽堿受體甲腎上腺乙酰膽碗乙酰膽堿受體腎上腺素能受體「《膽堿受體N膽堿受體效應(yīng)器骨骼肌第三章外周神經(jīng)系統(tǒng)藥物◎膽堿能神經(jīng)系統(tǒng)藥物上腺素能神經(jīng)系統(tǒng)藥物組H1受體拮抗劑ρ局部麻醉藥≯傳出神經(jīng)系統(tǒng)自主神經(jīng)運(yùn)動神經(jīng)CNS乙酰膽堿N膽堿受體無神經(jīng)節(jié)神經(jīng)遞質(zhì)乙酰膽堿神經(jīng)節(jié)N膽堿受體甲腎上腺乙酰膽碗乙酰膽堿受體腎上腺素能受體「《膽堿受體N膽堿受體效應(yīng)器骨骼肌第三章外周神經(jīng)系統(tǒng)藥物◎膽堿能神經(jīng)系統(tǒng)藥物上腺素能神經(jīng)系統(tǒng)藥物組H1受體拮抗劑ρ局部麻醉藥≯腎上腺素能神經(jīng)系統(tǒng)藥物去甲腎上腺素的生物合成、代謝及作用腎上腺素受體激動劑(腎上腺素、麻黃堿)腎上腺素受體拮抗劑(普萘洛爾)多巴胺、去甲腎上腺素和腎上腺素的生物合成rosine-3-monooxygenase(tyrosinehydroxylase)COOHHOHONH2(S)-(-)-Tyrosine(L)(S)-(-)-Dopa(L)aromaticL-aminoacidHONH2decarboxylasedopamineB-hydroxylaseOHOHHOINH2ethanolamine-HOmethyltransferaseCH3HO(L)鄰苯二酚R)-(-)-Epinephrine①NE的生物合成、貯存、釋放和攝取SYMPATHETICVARICOSITYTYROSINEEFFECTORNECELLrTYROSINEDOPANENENEOMTNE0-NEHNEy-NE→(ANEURO-EFFECTORJUNCTION腎上腺素受體腎上腺素受體分為兩大類α受體:α1aβ受體:β1,β2,β3根據(jù)生理效應(yīng)的不同,腎上腺素能受體可分為激動劑拮抗劑0受體(擬似)(腎上腺素作用的反轉(zhuǎn)臟效應(yīng)細(xì)胞adrenalineseversal)血管平滑肌擴(kuò)瞳肌升壓降壓毛發(fā)運(yùn)動平滑肌抗休克改善微循環(huán)突觸前膜和后膜2血管平滑肌血小板、脂肪細(xì)胞降血壓β受體心率失常心臟、腎臟、腦干強(qiáng)心和抗休克高血壓,心絞痛阝2子宮肌、氣管平喘和改善微循環(huán),可抑制組胺和慢胃腸道、血管壁反應(yīng)物質(zhì)的釋放,防止早產(chǎn)β3雕脂肪防組織激動時分解脂肪,增加氧耗,減肥和糖尿病NE的代謝CHONorephephrineCOMTMAOCHOCHOARARCH3oCH3OCH2OCOoHCOoHCH2OHH