侯圣陶博士簡介

侯圣陶博士簡介現(xiàn)任職務(wù)：加拿大國家研究院生物科學(xué)研究所腦血管研究組組長職稱：加拿大國家研究院生物科學(xué)研究所高級研究員渥太華大學(xué)（加拿大）兼職教授近期主要研究內(nèi)容，方向及代表性成果近十年來主要從事神經(jīng)細(xì)胞凋亡機(jī)制及基因治療研究。自1996年起主持10多項(xiàng)包括加拿大國家科學(xué)院和加拿大心臟及中風(fēng)基金會的項(xiàng)目。2000年起參與并主持了加拿大國家科學(xué)院的HealthandGenomicsInitiatives項(xiàng)目(二百五十萬加元)。研究方向?yàn)槿毖鹕窠?jīng)細(xì)胞凋亡的分子機(jī)制和基因治療。在世界上首次證明轉(zhuǎn)錄因子E2F1可調(diào)解分化成熟的神經(jīng)細(xì)胞凋亡，E2F1信號傳導(dǎo)通路會被許多導(dǎo)致細(xì)胞死亡的因素激活，如多巴胺(dopamine),β-amyloid,低鉀(lowK+),Fas-受體激活及缺氧和糖處理(oxygen-glucose-deprivation)等。最重要的發(fā)現(xiàn)是腦缺血造成的神經(jīng)組織損傷在E2F1-/-的小鼠上明顯小于E2F1+/+。用基因芯片技術(shù)，發(fā)現(xiàn)幾組E2F1的靶基因，理解E2F1靶基因調(diào)節(jié)神經(jīng)細(xì)胞凋亡的機(jī)制對治療神經(jīng)變性疾病，如老年癡呆，帕金森氏癥，腦中風(fēng)及青光眼等有非常重要的意義。經(jīng)過近三年的研究，侯圣陶教授于2005年在國際上首次報道成功構(gòu)建低氧誘導(dǎo)、神經(jīng)元特異性腺病毒表達(dá)載體p5HRE-3NRSE，該基因治療載體是研究缺血相關(guān)神經(jīng)變性疾病如腦中風(fēng)、青光眼的重要工作，并具有潛在的臨床應(yīng)用價值。獲得過多項(xiàng)英國和加拿大研究組織獎勵和資助，曾多次受邀在國際會議和研究機(jī)構(gòu)宣讀論文，在SCI收錄的雜志上共發(fā)表30篇論文，其中包括J.Neurosci，J.Biol.Chem.，J.Neurochem.等雜志。另外，2項(xiàng)成果申請美國專利。學(xué)歷1988-1991 Ph.D.(CellBiology),FacultyofMedicine,UniversityofGlasgow,1984-1987 理學(xué)碩士,東北師范大學(xué)，長春。1980-1984 理學(xué)學(xué)士,遼寧師范大學(xué)，大連。工作經(jīng)歷2005-至今高級研究員(SeniorResearchOfficer),InstituteforBiologicalSciences,NationalResearchCouncilCanada加拿大國家研究院生物科學(xué)研究所2002-至今 兼職教授，DepartmentofBiochemistry,UniversityofOttawa,Canada渥太華大學(xué)生物化學(xué)、免疫及微生物系，加拿大2000-2005 副研究員(AssociateResearchOfficer),InstituteforBiologicalSciences,NationalResearchCouncilCanada加拿大國家研究院生物科學(xué)研究所1996-2000 助理研究員(AssistantResearchOfficer),InstituteforBiologicalSciences,NationalResearchCouncilCanada加拿大國家研究院生物科學(xué)研究所博士后(ResearchAssociate),DeptofBiochemistry,UniversityofBristol,UK.英國布魯塞爾大學(xué)，生物化學(xué)系1991-1993博士后(PostdoctoralResearchFellow),DeptofNeuropathology,InstituteofPsychiatry,UniversityofLondon,UK.英國倫敦大學(xué),神經(jīng)病理系1988-1991 助教(TeachingAssistant),FacultyofMedicine,UniversityofGlasgow,UK.英國格拉斯哥大學(xué)，醫(yī)學(xué)院獲獎情況2003-2005BritishCouncil&NRCScienceandTechnologyFund2000TravelAward，國際神經(jīng)化學(xué)年會1995中國人事部客座訪問學(xué)者PostdoctoralFellowship,英國生物及技術(shù)研究委員會(BBSRC),PostdoctoralFellowship,英國醫(yī)學(xué)研究委員會(MRC),GlasgowUniversityResearchStudentScholarship,哥拉斯格大學(xué)，PrincipleandVice-chancellor’sOverseasResearchStudentAward，英國大學(xué)校長基金會獎參與的國際學(xué)術(shù)團(tuán)體FullMember,InternationalSocietyforNeurochemistryFullMember,SocietyforNeuroscience(USA)MemberoftheScientificProgramCommittee,19thInternationalCongressofBiochemistryandMolecularBiology,Toronto(CANADA)20-25July2003MemberoftheNSERC(Canada)Committee(responsibleforreviewinggrantapplications)指導(dǎo)研究生情況親自和參與指導(dǎo)了6名博士后，多名博士，碩士生以及本科生的畢業(yè)論文工作。近年代表著作如下（累計(jì)：IF130多分）

PublishedandSubmittedRefereedPapersinthelast5years(*indicatescorrespondingauthor)HouST*,KeklikianA,SlinnJ,O'HareM,JiangSX,AylsworthA.(2008)Sustainedup-regulationofsemaphorin3A,Neuropilin1,anddoublecortinexpressioninischemicmousebrainduringlong-termrecovery.BiochemBiophysResCommun.367:109-15.IF:2.749RyanSD,HarrisCS,MoF,LeeH,HouST,BazanNG,HaddadPS,ArnasonJT,BennettSA.(2007)Plateletactivatingfactor-inducedneuronalapoptosisisinitiatedindependentlyofitsG-proteincoupledPAFreceptorandisinhibitedbythebenzoateorsellinicacid.JNeurochem.103:88-97.IF:4.451JiangSX,KapplerJ,ZurakowskiB,DesboisA,AylsworthA,HouST*.(2007)Calpaincleavageofcollapsinresponsemediatorproteinsinischemicmousebrain.EurJNeurosci.26:801-9.IF:3.673DuftyBM,WarnerLR,HouST*,JiangSX,Gomez-IslaT,LeenhoutsKM,OxfordJT,FeanyMB,MasliahE,RohnTT.(2007)Calpain-cleavageofalpha-synuclein:connectingproteolyticprocessingtodisease-linkedaggregation.AmJPathol.170:1725-38.HouST*,JiangSX,HuangD,DesboisA.(2007)Anoveladenoviralvector-mediatedneuronalselectivegeneexpressioninneonatalmousebraininresponsetohypoxia.NeurosciLett.419:23-7.IF:2.085JiangSX,SheldrickM,DesboisA,SlinnJ,HouST*.(2007)Neuropilin-1isadirecttargetofthetranscriptionfactorE2F1duringcerebralischemia-inducedneuronaldeathinvivo.MolCellBiol.27:1696-705.IF:6.42Hou,ST*,JiangSX,DesboisD,HuangDQ,KellyJ,TessierL,KarchewskiL,KapplerJ(2006)Calpain-CleavedCollapsinResponseMediatorProtein-3InducesNeuronalDeathafterGlutamateToxicityandCerebralIschemia.JNeurosci26(8)1-9.IF:7.49JiangSX,LertvorachonJ,HouST*,KonishiY,WebsterJ,MealingG,BrunetteE,TauskelaJ,PrestonE.(2005)Chlortetracyclineanddemeclocyclineprotectmouseneuronsagasintglutamatetoxicityandcerebralischemiathroughinhibitionofcalpain.JBC280:33811-33818.IF:5.581WeaverJGR,TarzeA,MoffatTC,LeBrasM,DeniaudA,BrennerC,BrenGD,MorinMY,PhenixBN,MillerB,DongL,JiangSX,SimVL,ZurakowskiB,LallierJ,HardinH,WettsteinP,vanHeeswijkRPG,DouenA,KroemerR,HouST,BennettSAL,LynchDH,KroemerG,BadleyAD.(2005)InhibitionofAdenineNucleotideTranslocatorPoreFunctionandProtectionAgainstApoptosisinvivobyanHIVProteaseInhibitor.JClinicalInvestigation115:1828-1838.(Iwasresponsibleformousestrokeworkperformedinthisstudy).IF:16.915Huang,D.,Desbois,A.andHou,ST*(2005)Anoveladenoviralvectorwhichmediateshypoxia-induciblegeneexpressionselectivelyinneurons.GeneTherapy12:1369-1376.IF:4.812LortieK,HuangD,ChakravarthyB,ComasT,HouST,Lin-ChaoS,MorleyP(2005)Thegas7proteinpotentiatesNGF-mediateddifferentiationofPC12cells.BrainRes1036:27-34.IF:2.218LinYP,DesboisA,JiangS,HouST*(2005)P2receptorantagonistPPADSconfersneuroprotectionagainstglutamate/NMDAtoxicity.NeurosciLett.377:97-100.IF:2.085LinYP,DesboisA,JiangS,HouST*(2004)GroupBvitaminsprotectmurinecerebellargranulecellsfromglutamate/NMDAtoxicity.NeuroReport24,2241-2244.IF:2.163Hou,ST*,DoveM.,AndersonE.,ZhangJB.,MacKenzieCR(2004)Identificationofpolypeptideswithselectiveaffinitytointactmousecerebellargranuleneuronsfromarandompeptide-presentingphagelibrary.J.NeurosciMethods138,39-44.IF:1.884Huang,D.Q.,Walker,T.,DesboisA.,Collier,C.L.,ChartierJ.,ChenG.,DoveM.,Fang,H.,HouST*.(2004)Expressionofcoxsakie-adenovirusreceptorandintegrins3/5onhumanNT2neurons:thelackofintegrin3expressionmaylimittheefficiencyofadenovirus-mediatedgenetransfer.JMolNeurosci24,323-328.IF:1.735Smith,R.A.,Walker,T.,andHou,ST*(2003)InvolvementofthetranscriptionfactorE2F1/Rbinkainicacid-induceddeathofcerebellargranulecells.MolBrainRes.116,70-79.IF:1.997Hou,ST*,Becker,K.G.,Baggley,A.,Chen,G.,andWebster,J.(2003)High-densityDNAmicroarrayanalysisofgeneexpressionfollowingtransientfocalcerebralischemiainmouse.ExcerptaMedicaVol1736,1-12.Smith,R.A.,Walker,T.,Hou,ST*(2003):Adenosinereceptorligandsfailtoattenuatekainicacid-induceddeathofculturedmousecerebellarneurons.Ann.Anat.185,326-327.IF:0.817Hou,ST*.Xie,X.,Baggley,A.,Park,D.S.,Chen,G.,andWalker,T.(2002)ActivationoftheRb/E2F1pathwaybythenon-proliferativep38MAPkinaseduringFas(APO1/CD95)-mediatedneuronalapoptosis.JBiolChem.277,48764-48770.IF:5.581Hou,ST*.andMaManus,J.P.(2002)Molecularmechanismsofneuronaldeath-inducedbycerebralischemia.IntRevCytol.221,93-148.IF:5.506Hou,ST*,Cowan,E.,Walker,T.,Ohan,N.,Dove,M.,Rasqinha,I.,andMacManus,J.P.(2001)ThetranscriptionfactorE2F1promotesdopamine-evokedneuronalapoptosisbyamechanismindependentoftranscriptionalactivation.JNeurochem.78:287-297.IF:4.451Hou,ST*,Cowan,E.,Dostanic,S.,Rasquinha,I.,Comas,T.,Morley,P.,andMacManus,J.P.(2001)IncreasedexpressionofE2F1duringdopamine-evokedcaspase-3-mediatedapoptosisinratcorticalneurons.NeurosciLett.306:153-6.IF:2.085Gendron,T.F.,Mealing,G.A.,Paris,J.,Lou,A.,Edwards,A.,Hou,ST.,MacManus,J.P.,Hakim,A.M.,Morley,P.(2001)AttenuationofneurotoxicityincorticalculturesandhippocampalslicesfromE2F1knockoutmice.JNeurochem.78:316-324.IF:4.451Hou,ST*,Callaghan,D.,Fournier,M.C.,Hill,I.,Kang,L.,Massie,B.,Morley,P.,Murray,C.,Rasquinha,I.,Slack,R.,MacManus,J.P.(2000)ThetranscriptionfactorE2F1modulatesapoptosisofneurons.JNeurochem.75:91-100,IF:4.451O'Hare,M.J.,Hou,ST.,Morris,E.J.,Cregan,S.P.,Xu,Q.,Slack,R.S.,Park,D.S.(2000)InductionandmodulationofcerebellargranuleneurondeathbyE2F-1.JBiolChem.275:25358-64.IF:5.581Giovanni,A.,Keramaris,E.,Morris,E.J.,Hou,ST.,O'Hare,M.,Dyson,N.,Robertson,G.S.,Slack,R.S.,Park,D.S.(2000)E2F1mediatesdeathofB-amyloid-treatedcorticalneuronsinamannerindependentofp53anddependentonBaxandcaspase3.JBiolChem.275:11553-60.IF:5.581PublishedBooksandMonographs(asauthororeditor)HouSt*andSmithRA(2008)Decipheringthecuesandsignallingpathwaysofaxonalgrowthandregeneration.IntlRevCell&MolBiol(inpress)O’hare,M,andHou,ST*(2008)ThetranscriptionfactorE2Finneuronaldeath.ResearchSignpostpp.123-133.Hou,S.T.*,Becker,K.G.,Baggley,A.,Chen,G.,andWebster,J.(2003)High-densityDNAmicroarrayanalysisofgeneexpressionfollowingtransientfocalcerebralischemiainmouse.ExcerptaMedicaInternationalCongressSeriesVol1736,1-12.ElsevierScienceHou,S.T.(2001)Dissectinghumanneurodegenerativediseasesinthepostgenomicsera.APECTechnomartIVS&TForumpp83-97.MacManus,J.P.,Hou,S.T.,Jian,M.,Webster,J.,andZurakowski,B.(2000)AroleforthetranscriptionfactorE2F1inexperimentalstrokedamage.InPharmacologyofCerebralIschemia(J.KrieglsteinEd.),pp.17-25.MedpharmScientificPublishers,StuttgartPublishedAbstracts/NumberofNotes(includenameofjournal，titleofarticleanddatesubmitted)Hou,S.T,Jiang,S.X,Sheldrick,M,Desbois,A.(2005)Neuropilin-1isamoleculartargetofthetranscriptionfactorE2F1andisinvolvedincerebralischemia-inducedneuronaldeath.JCerebBloodFlowMetab(Brain05)S71.HuangD,DesboisA,andHouST(2004)Anoveladenoviralve