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Antibioticusedata:
thelongwayfromnumberstoknowledge
NicoBondtLEI,partofWageningenURInternationalconference15november2011.Antibioticusedata:
thelongContentpresentationAntibioticusageinperspectiveObjectiveforcollectionofantibioticusedataMonitoringinEuropeandtheNetherlandsHowtomeasureusageTrendsintheNetherlandsandEuropeExampleofcountrycomparisonConclusions.ContentpresentationAntibioticAntibioticusageinperspective-quantityOutpatienthumanuseinEurope:1to3%(ECDC)AnimalproductionNetherlands(LEI,2011):Exposurepigs&calves:decreasing,butstillhighAnimalcategoryEstimatedexposure2010(ddperanimalyear)Piglets25%Fatteningpigs5%Vealcalves15%Broilers7%Dairycattle2%13%.AntibioticusageinperspectivAntibioticusageinperspective-patternAnimalcategoryInNLmainlyuseof:SowsandpigletsTetracyclines,Trim./sulfa’sFatteningpigsTetracyclinesVealcalvesTetracyclines,Oralanti-infectivesBroilersPenicillins,Tetracyclin.,QuinolonesDairycattlePenicillins,CefalosporinsDifferencesfromhumanhealthperspectiveves.AntibioticusageinperspectivAntibioticusageinperspective-qualityQualityofantibioticusage–prudence:AntibioticuseshouldbelimitedtosituationswheretheyareneededSelectionoftherightantibioticCompliancewiththeprescriptionAdequatedoseanddurationsource:FederationofVeterinariansofEurope.AntibioticusageinperspectivObjectiveforcollectionofantibioticusedataTogaininsightinto:totalamountofantibioticssoldlevelofexposureofanimalstoantibioticsqualityofantibioticuse:prudencerelationshipbetweenusageandantimicrobialresistanceinanimalsandanimalproductsrisksofantimicrobialresistanceinanimalsforhumanhealth.ObjectiveforcollectionofanObjectiveforcollectionofantibioticusedataTogaininsightinto:totalamountofantibioticssoldlevelofexposureofanimalstoantibioticsqualityofantibioticuse:prudencerelationshipbetweenusageandantimicrobialresistanceinanimalsandanimalproductsrisksofantimicrobialresistanceinanimalsforhumanhealth.ObjectiveforcollectionofanMonitoringinEuropeESVACfirstreportSeptember2011:only9countriesrecentrequestEMAtoprovidesalesdata2010sentto22countriesEURegulation726/2004legalbasisfornationalauthoritiestorequestsalesdatafrompharmaceuticalcompaniesNoobligationforEUcountriestoinformBrussels.MonitoringinEuropeESVAC.MonitoringintheNetherlands-1Nationaltotalsalesdataasfrom1999-FIDINwebsite:www.fidin.nl
Nationalusagedataasfrom2002-MARANwebsite:www.maran.wur.nl
Increasinginterestindividualfarms&vets(2010)website:www.antibioticawijzer.nl(inDutch)Centralizeddatacollection(2011)VetCISandprivatequalitysystems(IKB)EstablishmentofAnimalDrugAuthority(SDa).MonitoringintheNetherlandsMonitoringintheNetherlands-2FIDINtotalsalesdata+allsales(98%)+lowadministrativeburden-/-nodistinctionbetweenlivestocksectorsMARANbasedonFADNsamplefarms+detailsperlivestocksector+highqualityofcollecteddata+relationshipwithotherfarmcharacteristics-/-sample(appr.400farms).MonitoringintheNetherlandsHowtomeasureusageTotalsalesintonnesorinmg/kgmgantibiotics:addingupsubstances(e.g.oxy-doxy)kgoflivestock:addingupdifferentanimalspeciesExposure:numberofdaysundertreatmentAnimalDefinedDose(ADD;Jensenetal,2004)insightintoantibioticuseperspeciesdosageaccordingtosumm.ofproductcharacteristics?averageliveweightorweightattreatment?.HowtomeasureusageTotalsaleTotalsalesintheNetherlands(gramperkg;FIDIN).TotalsalesintheNetherlandsEstimatedexposureNLperspecies(dd/ay;LEI)www.maran.wur.nl.EstimatedexposureNLperspecSalespatternsNL&othercountries(EMA,2011)report‘Trendsinthesales(…)innineEuropeancountries’.SalespatternsNL&othercounTotalsalesNLandothercountries(EMA,2011)report‘Trendsinthesales(…)innineEuropeancountries’Notethedifferencesinthescales.TotalsalesNLandothercountExamplecountrycomparison–mgperkgTotalsales2010inNetherlands455tonactivesubst.Livestock2218tonliveweightTotalsalesperkg205mgperkgliveTotalsales2010inDenmark125.5tonactivesubst.Livestock1337tonliveweightTotalsalesperkg94mgperkgOwncalculationsbasedondataFIDIN,MARAN,DANMAP2010.Examplecountrycomparison–mExamplecountrycomparison–dd’sTotalsales2010inNetherlands455tonactivesubst.Livestock2218tonliveweightTotalsalesperkg205mgperkgliveCalculateddosage19mgp.kgp.dayEstimatedexposure10.8days/animalyearTotalsales2010inDenmark125.5tonactivesubst.Livestock1337tonliveweightTotalsalesperkg94mgperkgCalculateddosage16mgp.kgp.dayEstimatedexposure5.9days/animalyearprimarilybasedonsalespattern.Examplecountrycomparison–dComparisonanimaldemographics(%liveweight)importantdifference!DK:80%ofsales.ComparisonanimaldemographicsDifferencesinuseperspecies(estimate!)+475%+33%+100%.DifferencesinuseperspeciesSummaryexamplecountrycomparisontotalsales(NL;mg/kg): +118%estimatedexposure(NL): +83%estimatedexposureperanimalspecies(NL):pigs +33%cattle +100%vealcalves-poultry +475%+40-50%.SummaryexamplecountrycomparConclusionsabouttotalsalesdataTotalsalesdata:
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