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TheTripleHelix

HowThisInnovationModelhasSupportedtheSuccessofMDSSciexBillDavidsonMay10,2006MDSSciexWorld’slargestmanufacturerofmassspectrometersinthelifesciencesmarket>$550Minend-userrevenues550employeesinthreesites,230staffinR&D$50MR&DbudgetJointVenturewithAppliedBiosystemsMS/MS,LinearTrap,QqTOF,TOF/TOFJointVenturewithPerkinElmerICP/MSandprO-TOFJustlaunchedfirstnon-MSproduct–theCellKeycellanalysissystemWhatistheTripleHelix?Triple

HelixPianoTrioWhatistheTripleHelix?TheTripleHelixRockBandWhatistheTripleHelix?UniversityGovernmentIndustryFunding&StrategicNeedsNewProductConceptsDiagramofHowitWorksIndustryGovernmentAcademiaEmployment,Taxes,BenefitstoCitizensBenefitstoIndustryExpandlongtermandriskyresearchactivitiestoexpertsinthefieldObtainproprietarytechnologythroughlicensingagreementsLeveragefundingthroughmatchinggrantprojectsCollaboratingresearchlabsaresourceofnewrecruitsBenefitstoAcademiaExcellentsourceoffundingwithindustryandgovernmentsharingtheloadFundingallowsforcriticalmassofpersonnelandingeneralmoreefficientresearchTrainingofhighlyqualifiedpersonnelinindustrialrelatedresearchgoodforjobplacementsHelpsremovestigmaof“iviedwalls”ResearchgenerallybasedonstrategicneedsandhaslongrangebenefittothecommunityBenefitstoGovernmentNewindustriesandnewproductscanleadtohigheremploymentFinancialbenefitfromtaxesanddutiesHelpssupportstrategicR&DinitiativesManyproductshaveimpactonCanadiansinprovidingabetterlivestyleSuccessStoriesDevelopmentofTAGA6000AnMobileTaga6000forEnvironmentalMonitoringTaga6000(1980)PartiesInvolvedAcademiaUniversityofTorontoAerospaceInstitute,BarryFrenchwhohadhadexpertiseinionopticsinfreejetexpansionGovernmentNationalResearchCouncil,PeterDawsonwhohadworldleadingexpertiseinquadrupoledesignDepartmentofIndustry(PILPprogram)IndustrySciexInc.OutcomeTheTAGA6000wasthefirstcommercialtriplequadrupolemassspectrometerIntroducedin1980,itwasthefoundationforSciex’scommercialsuccessSciexnowisworldleaderinproductionoftriplequadrupoleMajorsourceoflicensingrevenuefortheNRCandUofTLedtothousandofCanadianjobsOff-springproductsnowusedindevelopmentofdrugs,neonatalandotherclinicalscreeningDevelopmentofELAN250PartiesInvolvedUniversityofTorontoInstituteforAerospaceStudiesDr.BarryFrenchwhohadexpertiseininterfacingatmosphericpressureionsourceswithMSMDSSciexDr.DonDouglaswhowasthefirsttoaccomplishthisinterface.NationalResearchCouncilDr.JimMcLarenwhowasaleaderinelementalanalysisDepartmentofIndustryOutcomeTheElan250wasthefirstcommercialICP/MSusedfortraceelementdetectionItprovedtobethecatalystintheformationofajointventurebetweenSciexandPerkinElmerMarketnowinclude:clinical,environmental,semi-conductor,homelandsecurity,medicalresearchMoreOutcomesNRCbecamethefirstuseroftechniqueandusedittodevelopcalibrationstandardsNRCreceivedroyaltiesasrepaymentofgovernmentgrantSeveralhundredjobscreatedovertheyearsDiversifiedSciex’sproductlineandkeptcompanyaliveinthemid-80sDevelopmentofELAN6000andAPI300PartiesInvolvedUniversityofTorontoInstituteforAerospaceStudiesDr.BarryFrenchSeveralSciexscientistssecondedtoUTIASMDSSciexPerkinElmerOntarioTechnologyFundOutcomesAPI300becametheplatformtriplequadrupolesystemforMDSSciexandwithhighmarginsledtoaddedprofitabilityElan6000alsobecametheplatformICP/MS,andbecamethemarketleaderinelementalanalysis$17Mgovernmentinvestmenthasleadtoover$3BinrevenuesMoreOutcomesThisprojectbecamethe“model”projectforbelieversinthetriplehelixmodelofinnovationItgaveMDSSciextheabilitytocompetegloballyandledtooursuccessintheindustryUTIASstudentsandpost-docswentontoexcellentpositionsinindustryandacademiaOTFdidn’tfairwellandwasstoppedwhenConservativestookpowerDevelopmentofQStarando-MALDICentaurPartiesInvolvedUniversityofManitobaDr.KenStandingandWernerEns,expertsintime-of-flight(TOF)technologyMDSSciexDr.BruceThomsonandothers,expertsinquadrupoletechnologyAppliedBiosystemsInstituteforMarineBiosciencesDr.BobBoydandothers,expertsintheuseofMSinbioanalyticalworkNSERCOutcomesTheQStarwasthefirstTOFinstrumentdevelopedbyMDSSciexItisnowakeyproductinbiomarkerdiscoverandproteinidentificationo-MALDIprovedtobeapowerfultoolinproteomicsandnowisusedtotissueimaging,highthroughputassaysUofManitobaandSciexwereawardedanNSERCSynergyAwardforthisprojectMoreOutcomesRoyaltiesandotherlicensingfeeswereamajorsourceofrevenueforUManitoba(andstillare)UManitobabecamekeyplayerinproteomicsarenaKeymemberofSciex’spresentresearchgroupcamefromUManitobaandIMBThisisalsoviewedasamodelofhowacademia,industryandgovernmentprojectscanbebeneficialtoallWhenProjectsareSuccessfulIndustryAcademiaGovernmentNotSoSuccessfulDNASequencerTheAppliedBiosystemsPrism3700PartiesInvolvedUniversityofAlbertaDr.NormDovichi,expertincapillaryelectrophoresisGeneticDiseaseNetworkBacterialDiseaseNetworkMDSSciexNSERCOutcomesILOofficelateinpatentingcertainaspectsofthetechnologyMDSSciexunabletocommercializeproductAppliedBiosystemslicensestechnologyfromSciexandcreatesthefirsthighthroughput,capillarybasedDNAsequencerThistechnologyledtothesequencingoftheHumanGenomeJobcreationinCanadalessthan5salespersons.WhatwentwrongUniversityunder-estimatedvalueofthetechnologyMDSSciexdidnothavetheresourcebasetocommercializeanon-MSproductAppliedBiosystemshadotherkeypatentsinplacethatrestrictedSciexDovichibecameunder-funded,andwenttotheUSMSProteinSequencerTheTobyProjectPartiesInvolvedBiomedicalResearchCentre(UniversityofBritishColumbia)Dr.RuediAbersold,aleaderinproteincharacterizationMDSSciexIndustryCanadaOutcomeThreeprototypeswerebuiltbutnocommercialproductwasevermadeIndustryCanadadidnotreceiveanyofitsinvestmentbackTechnologyworked,butovertakenbyotherMSapproaches(alsodevelopedbyMDSSciex)WhatwentwrongAcceptanceofthetechnologywasslowsinceallfundingwasdirectedtowardsDNAsequencingatthetimeWellcomefoundationpullsoutofBRCandsomefundingdisappearsThecomplexityofthetechnologymadeitsomewhatunattractiveWithBRCtransferringtoUBC,fundingbecomesaproblemandRuediAebersoldleavesforUWashingtonLackofGovernmentFundingLeadsto“Separation”CanadianResearcherFundingAgencyGenomeCanadaCompetitionsCompetitionIIMDSSciexandGenomePrairieteamupto“DevelopEnablingTechnologiesforProteomicsResearch”Competition–HumanHealthUniversityHospitalNetwork,MDSSciexandOntarioGenomicsInstitutesuccessfulin“DevelopmentofMS-basedCytometersforStemCellResearch”CompetitionIIIMDSSciex,GenomePrairieandMt.SinaiHospitalproposetodevelopnewtoolsforbiomarkerdiscoveryandvalidationOutcomesCompetitionIIProjectusedasanexampletoparliamentastothevalueoflarge-scaleprojectsinvolvingthetriplehelixCompetition–HumanHealthMDSSciexbacksoutofmajorfundingduetohighcommercialrisk.Sciexresearchersformnewcompanytocontinueproject.CompetitionI

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