Kojic-acid-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEKojicacid(Standard)Cat.No.:HY-W050154RCASNo.:501-30-4分?式:C?H?O?分?量:142.11作?靶點(diǎn):Parasite;Tyrosinase;NF-κB;CDK作?通路:Anti-infection;MetabolicEnzyme/Protease;NF-κB;CellCycle/DNADamage儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Kojicacid(Standard)Kojicacid的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Kojicacid由Aspergillusoryzae產(chǎn)?的物質(zhì)，具有抗腫瘤、抗?、抗、抗氧化、防輻射等多種?物活性。Kojicacid具有酪氨酸酶抑制活性，通過(guò)捕獲與酪氨酸酶活性位點(diǎn)結(jié)合的銅離?防?其激活，酪氨酸酶??素?物合成的核?酶，因此Kojicacid可以阻???素產(chǎn)?。此外，Kojicacid顯?出對(duì)??質(zhì)形成細(xì)胞中NF-κB活性的潛在抑制作?，這種對(duì)NF-κB的抑制作?也可能與曲酸誘導(dǎo)的抗??素效應(yīng)有關(guān)。Kojicacid具有?服有效性也可被透?吸收，由Kojicacid制備的納?載體系統(tǒng)顯?出對(duì)抗癌藥物的有效遞送。Kojicacid有望?于癌癥、感染疾病及美?等多領(lǐng)域研究[1]。REFERENCES[1].WeiX,etal.KojicacidinhibitssenescenceofhumancornealendothelialcellsviaNF-κBandp21signalingpathways.ExpEyeRes.2018Dec28;180:174-183.[2].BurnettCL,etal.Finalreportofthesafetyassessmentofkojicacidasusedincosmetics[J].Internationaljournaloftoxicology,2010,29(6_suppl):244S-273S.[3].SaeediM,etal.Kojicacidapplicationsincosmeticandpharmaceuticalpreparations.BiomedPharmacother.2019Feb;110:582-593.doi:10.1016/j.biopha.2018.12.006.[4].KimTY,etal.NematicidalactivityofkojicacidproducedbyAspergillusoryzaeagainstMeloidogyneincognita[J].JournalofMicrobiologyandBiotechnology,2016,26(8):1383-1391.[5].ZillesJC,etal.Biologicalactivitiesandsafetydataofkojicacidanditsderivatives:Areview[J].Experimentaldermatology,2022,31(10):1500-1521.[6].KaiH,etal.Assessmentoftheeffectofarbutinisomersandkojicacidonmelaninproduction,tyrosinaseactivity,andtyrosinaseexpressioninB16-4A5andHMV-IImelanomacells[J].PlantaMedicaLetters,2015,2(01):e39-e41.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[7].KarakayaG,etal.Synthesisandcytotoxicevaluationofkojicacidderivativeswithinhibitoryactivityonmelanogenesisinhumanmelanomacells[J].Anti-CancerAgentsinMedicinalChemistry(FormerlyCurrentMedicinalChemistry-Anti-CancerAgents),2018,18(15):2137-2148.[8].KhanA,etal.AntioxidativeandAnti-inflammatoryEffectsofKojicAcidinAβ-InducedMouseModelofAlzheimer'sDisease.MolNeurobiol.2021Oct;58(10):5127-5140.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresear