plus-Kavain-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemE(+)-Kavain(Standard)Cat.No.:HY-B1671RCASNo.:500-64-1分子式:C??H??O?分子量:230.26作用靶點(diǎn):GABAReceptor;SodiumChannel;CalciumChannel作用通路:MembraneTransporter/IonChannel;NeuronalSignaling儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性(+)-Kavain(Standard)是(+)-Kavain的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。(+)-Kavain是從卡瓦胡椒(Pipermethysticum)中提取的一種主要的卡瓦內(nèi)酯，具有抗驚厥作用，通過電壓依賴性的Na+和Ca2+通道相互作用，減弱血管平滑肌的收縮[1]。Kavain能與α4β2δGABAA受體結(jié)合，加強(qiáng)GABA的功效[2]。Kavain可用于炎癥疾病研究[4]。IC50&TargetNa+,Ca2+channel[1].α4β2δGABAAreceptor[2].REFERENCESBradi?I,etal.[Hirschsprung'sdisease--therapyandresults].ActaChirIugosl.1975;22(2):183-95.ChuaHC,etal.Kavain,theMajorConstituentoftheAnxiolyticKavaExtract,PotentiatesGABAAReceptors:FunctionalCharacteristicsandMolecularMechanism.PLoSOne.2016Jun22;11(6):e0157700.G.Boonen,etal.InvivoEffectsoftheKavapyrones(+)-Dihydromethysticinand(±)-KavainonDopamine,3,4-DihydroxyphenylaceticAcid,Serotoninand5-HydroxyindoleaceticAcidLevelsinStriatalandCorticalBrainRegions.PlantaMedica64(1998)507-510.TangX,etal.KavainInhibitionofLPS-InducedTNF-αviaERK/LITAF.ToxicolRes(Camb).2016Jan1;5(1):188-196.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:02