Flunixin-Sch-14714-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEFlunixinCat.No.:HY-121046CASNo.:38677-85-9Synonyms:Sch14714分?式:C??H??F?N?O?分?量:296.24作?靶點(diǎn):COX作?通路:Immunology/Inflammation儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Flunixin?種環(huán)氧化酶(COX)抑制劑，對(duì)COX-1和COX-2的IC50值分別為0.55和3.24μM，其具有抗炎作?。IC50&TargetCOX-1COX-20.55μM(IC50)3.24μM(IC50)體外研究flunixinmeglumine(10-1000μM,2h)inhibitslipopolysaccharide(LPS)-inducedactivityofinduciblenitricoxidesynthase(iNOS)inRAW264.7murinemacrophages[2].flunixinmeglumine(10-1000μM,2h)inhibitslipopolysaccharide-inducedactivationofnuclearfactorkappaB(NfκB)inRAW264.7murinemacrophages[2].CellViabilityAssay[2]CellLine:RAW264.7murinemacrophagesConcentration:10,100,300,and1000μMIncubationTime:2hoursResult:InhibitedLPS-inducednitricoxidereleaseatconcentrationsbetween100and1,000μM(P=0.01).體內(nèi)研究Flunixinmeglumine(intravenousinjection;1.1mg/kg;once)treatmentinhibitstheformationofexudatePGE21/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEandserumTXB2[1].AnimalModel:MalesheepinjectedwithCarrageenan[1]Dosage:1.1mg/kgAdministration:Intravenousinjection;1.1mg/kg;onceResult:InhibitedCarrageenan-inducedexudatePGE2formation(Emax,100%,IC50,max,100%,IC50,17nM)forupto32h.REFERENCES[1].ZCheng,etal.Measurementofcyclooxygenaseinhibitioninvivo:astudyoftwonon-steroidalanti-inflammatorydrugsinsheep.Inflammation.1998Aug;22(4):353-66.[2].ClareEBryant,etal.EvaluationoftheabilityofcarprofenandflunixinmegluminetoinhibitactivationofnuclearfactorkappaB.AmJVetRes.2003Feb;64(2):211-5.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379