C1s-IN-1-trihydrochloride-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEC1s-IN-1trihydrochlorideCat.No.:HY-W371165CASNo.:1376162-36-5分?式:C??H??Cl?N?分?量:390.74作?靶點(diǎn):ComplementSystem作?通路:Immunology/Inflammation儲(chǔ)存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:125mg/mL(319.91mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.5592mL12.7962mL25.5925mL5mM0.5118mL2.5592mL5.1185mL10mM0.2559mL1.2796mL2.5592mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲(chǔ)存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性C1s-IN-1trihydrochloride(CompoundA1)C1s蛋?酶(C1sprotease)的選擇性抑制劑，Ki為5.8μM。C1s-IN-1trihydrochloride可抑制C1s對C2的裂解，IC50為85μM，可抑制經(jīng)典途徑的激活，IC50為22μM。C1s-IN-1trihydrochloride凝?酶(thrombin)的競爭性抑制劑，Ki為51.2μM。IC50&TargetKi:5.8μM(C1sprotease);51.2μM(thrombin)REFERENCES1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1].XuX,etal.,InhibitionoftheC1sProteaseandtheClassicalComplementPathwayby6-(4-Phenylpiperazin-1-yl)Pyridine-3-CarboximidamideandChemicalAnalogs.JImmunol.2024Feb15;212(4):689-701.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021