生物信息學(xué) 相關(guān)數(shù)據(jù)庫(kù)資源介紹

1、生物信息學(xué) 相關(guān)數(shù)據(jù)庫(kù)資源介紹,劉 吉 平 Reference： ,生物信息學(xué)相關(guān)數(shù)據(jù)庫(kù)資源,核酸及其相關(guān)數(shù)據(jù)庫(kù)（核酸序列、基因組相關(guān)數(shù)據(jù)庫(kù)、核酸三維結(jié)構(gòu)、其他） 蛋白質(zhì)相關(guān)數(shù)據(jù)庫(kù)（蛋白質(zhì)序列、蛋白質(zhì)三維結(jié)構(gòu)、蛋白質(zhì)組（二維凝膠電泳數(shù)據(jù)庫(kù)）、信號(hào)傳導(dǎo)及蛋白質(zhì)-蛋白質(zhì)相互作用相關(guān)數(shù)據(jù)庫(kù)、DNA和蛋白質(zhì)相互作用數(shù)據(jù)庫(kù)） 基因或蛋白質(zhì)一些特定數(shù)據(jù)庫(kù) 糖類及其相關(guān)數(shù)據(jù)庫(kù) 蛋白質(zhì)翻譯后修飾相關(guān)數(shù)據(jù)庫(kù) 基因表達(dá)數(shù)據(jù)庫(kù) 人類基因突變及疾病相關(guān)數(shù)據(jù)庫(kù) 進(jìn)化相關(guān)數(shù)據(jù)庫(kù)及資源專利數(shù)據(jù)庫(kù) 資源目錄服務(wù)器或網(wǎng)頁(yè),一、核酸及其相關(guān)數(shù)據(jù)庫(kù),1、核酸序列數(shù)據(jù)庫(kù) EMBL - EMBL Nucl

2、eotide sequence database (EBI) * GenBank - GenBank Nucleotide Sequence database (NCBI) * DDBJ - DNA Data Bank of Japan * BIOSINO 我國(guó)的核酸序列公共數(shù)據(jù)庫(kù) dbEST - Database of Expressed Sequence Tags (NCBI) dbSTS - Database of Sequence Tagged Sites (NCBI),2.基因組及相關(guān)數(shù)據(jù)庫(kù) Genomic Databases,GenomeWeb(HGMP) - A catalogu

3、e of useful Web sites for Genomics with a set of collections of genome databases GSDB - Genome Sequence database (NCGR) GOLD - Genomes On-line db 一些數(shù)據(jù)庫(kù)的直接鏈接,3.核酸三維結(jié)構(gòu)數(shù)據(jù)庫(kù),NDB - Nucleic Acid Databank (3D structures) BNASDB - Nucleic acid structure db from University of Pune,4.其他,AsDb - Aberrant Splicin

4、g db ACUTS - Ancient conserved untranslated DNA sequences db Codon Usage Db - The frequency of codon use in each organism is made searchable through this World Wide Web site. EPD - Eukaryotic Promoter db HOVERGEN - Homologous Vertebrate Genes db IMGT - ImMunoGeneTics db Mirror at EBI ISIS - Intron S

5、equence and Information System RDP - Ribosomal db Project gRNAs db - Guide RNA db PLACE - Plant cis-acting regulatory DNA elements db,其它,PlantCARE - Plant cis-acting regulatory DNA elements db sRNA db - Small RNA db ssu rRNA - Small ribosomal subunit db lsu rRNA - Large ribosomal subunit db 5S rRNA

6、- 5S ribosomal RNA db tmRNA Website tmRDB - tmRNA dB tRNA - tRNA compilation from the University of Bayreuth uRNADB - uRNA db,其他,RNA editing - RNA editing site RNAmod db - RNA modification db TelDB - Multimedia Telomere Resource TRADAT - TRAnscription Databases and Analysis Tools Subviral RNA db - S

7、mall circular RNAs db (viroid and viroid-like),Transgenics,Cre Transgenic Database - Cre transgenic mouse lines Transgenic/Targeted Mutation Database - Information on transgenic animals and targeted mutations,二.蛋白質(zhì)序列和相關(guān)數(shù)據(jù)庫(kù),SWISS-PROT - SWISS-PROT annotated protein sequence db PIR-international -The

8、Protein Information Resource (protein sequence) MIPS - Martinsried institute for protein sequence and homology data and yeast genome information,蛋白質(zhì)及其相關(guān)數(shù)據(jù)庫(kù),PROSITE - PROSITE dictionary of protein sites and patterns InterPro - Integrated Resources of Proteins Domains and Functional Sites BLOCKS - BLO

9、CKS db DOMO - Protein domain db (Automatically generated) Pfam - Protein families db (HMM derived) Mirror at Sanger PRINTS - Protein Motif fingerprint db ProDom - Protein domain db (Automatically generated) PROTOMAP - An automatic hierarchical classification of SWISS-PROT proteins SBASE - SBASE doma

10、in db (Protein domain sequence library) SMART - Protein signalling and extracellular domain patterns (Simple Modular Architecture Research Tool) ProClass - Protein sequence alignments and curation of protein families,.蛋白質(zhì)三維結(jié)構(gòu)和相關(guān)數(shù)據(jù)庫(kù),PDB - Protein Data Bank Mirrors in EBI BioMagResBank - Repository fo

11、r data on proteins, peptides, and nucleic acids from NMR spectroscopy SWISS-MODEL Repository - Automatically generated protein models db ModBase - Db of comparative protein structure models CATH - UCL BSM structural classification of proteins SCOP - Structural classification of proteins Mirror at US

12、A | Israel | Singapore | Australia Mol_R_Us - Molecules R Us, browser for PDB BMM Domain Server - Biomolecular Modelling Laboratory (ICRF) protein domain server PRESAGE - Collaborative resource for structural genomics,蛋白質(zhì)三維結(jié)構(gòu)和相關(guān)數(shù)據(jù)庫(kù),SBASE - SBASE domain db (Protein domain sequence library) SMART - Pr

13、otein signalling and extracellular domain patterns (Simple Modular Architecture Research Tool) ProClass - Protein sequence alignments and curation of protein families Kabat - Kabat db of protein of immunological interest PMD - Protein Mutant db,蛋白質(zhì)二維凝膠電泳數(shù)據(jù)庫(kù),WORLD-2DPAGE - A complete index of 2D-PAGE

14、 db and servers Phoretix links - Phoretix page of links to 2D gel db,三、信號(hào)傳導(dǎo)及蛋白質(zhì)-蛋白質(zhì)相互作用相關(guān)數(shù)據(jù)庫(kù),DIP - Db of Interacting Proteins INTERACT - Protein-Protein interaction db ProNet - Protein-Protein interaction db CANSITE - Signal Transductions Web SPAD - Signaling pathway db CSNDB - Cell Signaling Networ

15、ks db,四、DNA和蛋白質(zhì)相互作用數(shù)據(jù)庫(kù),DPInteract - DNA-Proteins interactions db,五、特定基因或蛋白質(zhì)的數(shù)據(jù)庫(kù),AAA - AAA family of ATPases server Acetylcholinesterases ALDH - Aldehyde dehydrogenase gene superfamily db Aminoacyl-tRNA synthetases in SWISS-PROT - List of aminoacyl-tRNA synthetases in SWISS-PROT AARSDB - Aminoacyl-tR

16、NA synthetases db Allergens in SWISS-PROT - Nomenclature and index of allergens in SWISS-PROT,特定基因或蛋白質(zhì)的數(shù)據(jù)庫(kù),AMSDb - Antimicrobial sequences db Antibody resource page - Links to antibody related Web resources Australian venom and toxin db Bacillus thuringiensis toxin specificity db TFII - Basal transc

17、ription factors Blood group antigens in SWISS-PROT BCGD - Breast cancer genes db from MBCR BRENDA - Db of enzyme functional data,特定基因或蛋白質(zhì)的數(shù)據(jù)庫(kù),EF-hand CaBP - EF-hand calcium-binding proteins db CAZy - Carbohydrate-Active enZYmes Web site CBS domain - Cystathionine Beta Synthase domain WWW page CD ant

18、igens in SWISS-PROT - Nomenclature for surface proteins of human leucocytes (CD),特定基因或蛋白質(zhì)的數(shù)據(jù)庫(kù),CD antigens in PROW - Database on information about CD antigens Chaperonin - Information on GroEL and GroES chaperonins Conotoxins - Information on conotoxins from a Web site on cone shells。 etc。,糖類相關(guān)數(shù)據(jù)庫(kù),Ca

19、rbBank - Complex Carbohydrate Structure Database GlycoSuiteDB - Db of glycan structures TGN - The Glycoscience Network FCCA - Forum Carbohydrates Coming of Age CARBHYD - Carbohydrate information WWW sites Monosacharide browser - Space filling Fischer projection for monosaccharides,蛋白質(zhì)翻譯后修飾相關(guān)數(shù)據(jù)庫(kù),O-Gl

20、ycBase - O-glycosylated proteins db PhosphoBase - Phosphorylation sites db RESID - Db of Amino Acid Modifications,基因表達(dá)數(shù)據(jù)庫(kù),ASDB - Protein products and expression patterns of alternatively-spliced genes Axeldb - Gene expression in Xenopus BodyMap - Human and mouse gene expression data EpoDB - Genes ex

21、pressed in vertebrate RBC FlyView - Drosophila development and genetics Gene Expression Database (GXD) - Mouse gene expression and genomics Kidney Development Database - Kidney development and gene expression,基因表達(dá)數(shù)據(jù)庫(kù),MAGEST - Ascidian (Halocynthia roretzi) gene expression patterns Mouse Atlas and Ge

22、ne Expression Database - Spatially-mapped gene expression data PEDB - Normal and aberrant prostate gene expression Tooth Development Database - Gene expression in dental tissue TRIPLES - TRansposon-Insertion Phenotypes, Localization and Expression in Saccharomyces,人類基因突變及疾病相關(guān)數(shù)據(jù)庫(kù),HMGD - Human Gene Mu

23、tation db SVD - Sequence variation db HGBASE - Human Genic Bi-Allelic Sequences db The SNP consortium dbSNP - Human single nucleotide polymorphism (SNP) db List of mutation databases from OMIM List of mutation databases from IMT (Finland),人類基因突變及疾病相關(guān)數(shù)據(jù)庫(kù),ADB - Albinism db (Mutations in human genes ca

24、using albinism) Alpha-glucosidase - Information about human acid alpha-glucosidase (GSD-II) AR mutations - Human androgen receptor mutation db Antithrombin mutation db Asthma and Allergy gene db BIOMDB - Db of mutations causing tetrahydrobiopterin deficiencies BLMbase - Human BLM mutation db (Bloom

25、snydrom),人類基因突變及疾病相關(guān)數(shù)據(jù)庫(kù),BTKbase - Human BTK mutation db (X-linked agammaglobulinemia) CD40Lbase - Human CD40 ligand mutation db COL1/3 mutation - Human Type I and III collagen mutation db CFTR mutation - Human cystic fibrosis mutation db (CFTR) EMD db - Human Emerin (EMD) mutation db (Emery-Dreifuss

26、 muscular dystrophy) KMeyeDB - Eye disease genes db,人類基因突變及疾病相關(guān)數(shù)據(jù)庫(kù),FVII mutation - Human Factor VII mutation db HAMSTeRS - Human Factor VIII mutation db (Haemophilia A) HAeMB - Human Factor IX mutation db (Haemophilia B) FBN1 mutation - Human fibrillin 1 mutation db (Marfan syndrome) G6PD - Human G6

27、PD deficiency resource Galt mutation - Human galactose-1-phosphate uridylyltransferase mutation db (Galactosemia),人類基因突變及疾病相關(guān)數(shù)據(jù)庫(kù),HEXAdb - Human Hexosaminidase A mutation db (Tay-sachs disease) IL2RGbase - Human IL2RG (Interleukin-2 receptor gamma) mutation db (X-SCID) L1CAM mutation - Human L1CAM mu

28、tation db LDLR mutation - Human LDLR mutation db (Familial hypercholesterolemia) LQTSdb - Long QT syndrome db NCF1base - Human NCF1 mutation db NCF2base - Human NCF2 mutation db,人類基因突變及疾病相關(guān)數(shù)據(jù)庫(kù),Neuromuscular diseases web site NCL - Neuronal Ceroid Lipofuscinoses mutation db OTCase - Human ornithine t

29、ranscarbamylase (OTCase) website Cytochrome P450 alleles nomenclature p53 mutation db - University of Tokyo p53 mutation db Germline p53 mutation db - University of Prague db of germline p53 mutations PAHdb - Human phenylalanine hydroxylase (PAH) mutation db,人類基因突變及疾病相關(guān)數(shù)據(jù)庫(kù),PAX6 mutation - Human PAX6

30、 mutation db Prion - Prion and prion disease web site RAG1base - Human RAG1 mutation db RAG2base - Human RAG2 mutation db RB1base - Human retinoblastoma-associated protein (RB) mutation db RetNet - Retinal Information Network Retina International Scientific Newsletter - Information on Retinal genes,

31、 proteins and diseases,人類基因突變及疾病相關(guān)數(shù)據(jù)庫(kù),TSC - TSC (TSC1/TSC2) variation db TSC2 - Cardiff-Rotterdam Tuberous Sclerosis (TS) db (Tuberin; TSC2) TGDB - Tumor gene db VMD2 mutation - Human VMD2 mutation db vWF mutation - Human von Willebrand factor (vWF) mutation db WRN - Human WRN mutation db (Warner di

32、sease) WT1 mutation - Human WT1 mutation db X-ALD mutation - Human ABCD1 mutation db,進(jìn)化相關(guān)數(shù)據(jù)庫(kù)及資源,Clusters of Orthologous Groups (COG) - Phylogenetic classification of proteins from 21 complete genomes XREFdb - Cross-referencing of model organism genetics with mammalian phenotypes TreeBASE - Relationa

33、l db of phylogenetic information The Tree of life - Collection of WWW pages on phylogeny and biodiversity of organisms,專利數(shù)據(jù)庫(kù),DPD - DNA Patent db Ag Patents - Agricultural Biotechnology patents from the USDA USPTO patent db - USA Patent and Trademark Office patent db Espcenet - Patent information dat

34、abase from the European Patent Office (worldwide coverage) The Delphion Intellectual Property Network (IPN) for searching, viewing, and analyzing patent documents.,資源目錄服務(wù)器或網(wǎng)頁(yè),BioCatalog - The BioCatalog at EBI Yellow BAGI - Bio Access Guide to the Internet at Houston University Software library from

35、 G DBCAT - Databases catalog at INFOBIOGEN MBDL - Molecular Biology Database List Amos WWW links page Nucleic Acids Research database issue,Human,CEPH-genotype database CEPH home page - a research laboratory which constructs maps of the human genome GeneMap99 - A Gene Map of the Human Genome (NCBI)

36、OMIM - Online Mendelian Inheritance in Man GENATLAS - Human genes atlas GeneClinics - Medical genetics knowledge base GDB - Human genes and genomic maps GeneCards - Db integrating information on human genes,Human,UDB - Unified db for Human genome mapping Ensembl - Human genome annotations site UCSC

37、human genome working draft TIGR HGI - TIGR Human Gene Index Human BAC Ends Database - Non-redundant human BAC end sequences Hs UniGene - Human transcripts in GenBank (EST clusters) STACK - Sequence Tag Alignment and Consensus Knowledgebase (Db of consensus human ESTs),Human,A - Human pred

38、icted gene index/catalog GenLink - Human genetics resource GENOTK - Human cDNA db HUGE - Human Unidentified Gene-Encoded large proteins cDNA (KIAA.) CGAP - Cancer Genome Anatomy Project SCDb - Stem cell db,Human,HuGeMap - Human genome genetic and physical map data G3-RH - Stanford G3 and TNG radiati

39、on hybrid maps GB4-RH - Genebridge4 (GB4) human radiation hybrid maps Radiation Hybrid Database - Radiation hybrid map data,Human chromosome 18,Chr1 - Human chromosome 1 at Rockefeller University Mirror at EBI Chr3 - Human chromosome 3 db at the University of Texas Health Science Center Chr7 - Human

40、 chromosome 7 db at Ontarios Hospital for Sick Children Chr8 SWISS-PROT list - Links to SWISS-PROT entries from human chromosome 8,Human chromosome911,Chr9 SWISS-PROT list - Links to SWISS-PROT entries from human chromosome 9 Chr9 - Human chromosome 9 db Chr10 SWISS-PROT list - Links to SWISS-PROT e

41、ntries from human chromosome 10 GTC Chr10 data - Human chromosome 10 data from Genome Therapeutics Corporation Chr11 SWISS-PROT list - Links to SWISS-PROT entries from human chromosome 11 11DB - Human chromosome 11 db at Imperial College (U.K.),Human chromosome1216,Chr12 SWISS-PROT list - Links to S

42、WISS-PROT entries from human chromosome 12 Chr13 - Human chromosome 13 db at Columbia Chr14 SWISS-PROT list - Links to SWISS-PROT entries from human chromosome 14 Chr15 SWISS-PROT list - Links to SWISS-PROT entries from human chromosome 15 Chr15 UBC - Human chromosome 15 WWW page at UBC Chr16 SWISS-

43、PROT list - Links to SWISS-PROT entries from human chromosome 16,Human chromosome1619,Chr16 LANL - Human chromosome 16 db at Los Alamos National Laboratory Chr16 TIGR - Human chromosome 16 db at TIGR Chr17 SWISS-PROT list - Links to SWISS-PROT entries from human chromosome 17 Chr18 SWISS-PROT list -

44、 Links to SWISS-PROT entries from human chromosome 18 Chr18 - Human chromosome 18 at Boston Childrens Hospital Chr19 SWISS-PROT list - Links to SWISS-PROT entries from human chromosome 19,Human chromosome2022,Chr20 SWISS-PROT list - Links to SWISS-PROT entries from human chromosome 20 Chr21 SWISS-PR

45、OT list - Links to SWISS-PROT entries from human chromosome 21 Chr21 at RIKEN - Human chromosome 21 genome site at RIKEN (Japan) Chr21 at ERI - Human chromosome 21 genomic sequence db from the Eleanor Roosevelt Institute Chr22 SWISS-PROT list - Links to SWISS-PROT entries from human chromosome 22 Ch

46、r22 at Sanger - Sanger Center chromosome 22 project Chr22 at HGC - Human genome center for chromosome 22,Human chromosomeXY,ChrX SWISS-PROT list - Links to SWISS-PROT entries from human chromosome X IXDB - Integrated X chromosome db ChrY SWISS-PROT list - Links to SWISS-PROT entries from human chrom

47、osome Y DRESH - Human cDNA clones homologous to Drosophila mutant genes,Vertebrates,OMIA - Online Mendelian Inheritance in Animals MGI - Mouse Genome Informatics (includes Mouse Genome Database (MGD)Mirrors in Australia | UK | Japan TIGR MGI - TIGR Mouse Gene Index Mm UniGene - Mouse transcripts in

48、GenBank (EST clusters) RatMAP - Rat genome db TIGR RGI - TIGR Rat Gene Index Rn Unigene - Rat transcripts in GenBank (EST clusters),Vertebrates,BovBASE - Bovine genome db (in UK) BOVMAP - Bovine genome db (in France) Ark-Cat - Cat genome db HorseBASE - Horse genome db DGP - Dog Genome Project PiGBAS

49、E - Pig genome db SheepBASE - Sheep genome db (also known as SheepMap) Mirror in UK MIS - Mendelian Inheritance in Sheep ChickGBASE - Chicken genome db,Vertebrates,Fugu - HGMP Resource Centre Fugu Project (Fugu rubripes) Medakafish - Mekada fish (Oryzias latipes) server Ark-Tilapia - Tilapia mossamb

50、ica genome db The fish net - Zebrafish server FishBase - Global information system on fishes,Mitochondrion and chloroplast,GOBASE - Organelle Genome Database MitoDat - Mendelian Inheritance and the Mitochondrion db (mitochondrial nuclear genes) MITOMAP - Human mitochondrial genome db MmtDB - Metazoa

51、 mitochondrial DNA variants db MitBASE - Integrated mitochondrial DNA db MitBASE-Pilot - Db of S.cerevisiae nuclear genes involved in mitochondrial biogenesis HvrBase - Primates mtDNA control region sequences compilation,Mitochondrion and chloroplast,MOUSE - Mitochondrial and Other Useful SEquences

52、(human and apes mit. DNA db) MITOP - Mitochondrial proteins, genes and diseases AMmtDB - Metazoan mitochondrial DNA sequences,Insects,Drosophila SWISS-PROT list - Links to Drosophila SWISS-PROT entries FlyBase - Drosophila genetic and molecular db Mirror at EBI FlyView - Drosophila image db GIFTS -

53、Gene Interactions in the Fly Trans-World Server FlyNets - Db of molecular interactions in Drosophila melanogaster SOS-DGBD - Db of Drosophila DNA sequences annotated with regulatory binding sites Mosquito Genomics,Invertebrates,WormBase - C.elegans db Mirror at Sanger C.elegans WWW server - at Unive

54、rsity of Texas Southwestern ACeDb - Caenorhabditis elegans db C.elegans Mitochondrial Directory - Data on C.elegans genes for mitochondrial proteins C.elegans EST - C.elegans EST db from Japan (Yuji Koharas group) C.elegans SWISS-PROT list - Links to C.elegans SWISS-PROT entries WormPep - C.elegans

55、proteins db WormPD - C.elegans protein db,Invertebrates,Dictystelium Genome Sequencing project at BCM Dictyostelium discoideum genome project at IENA DictyDb - Dictyostelium discoideum db Dicty_cDB - Dictyostelium discoideum cDNA project Cone shells Web site Parasite genomes db and resources Parasit

56、e genomes WWW site PlasmoDB - P.falciparum genome db,Invertebrates,Malaria - WHO - Malaria db (from WHO) （瘧疾nue） P.falciparum Sanger - P.falciparum genome project at Sanger PFDB - Plasmodium falciparum Genome db （瘧原蟲） P.falciparum - Plasmodium falciparum Gene Sequence Tag project,Invertebrates,MAD -

57、 Malaria Antigen db Malaria parasite metabolic pathways LGN - Leishmania Genome Network Trypanosoma brucei genome project Trypanosoma cruzi genome project kDNA - Kinetoplast Minicircle Sequence db,Plants,NAL - AGIS - Access to many plant genome databases at the National Agricultural Library Demeters

58、 genomes - Access to many plant genome databases at the USDA-ARS Mendel - Plant gene nomenclature database from CPGN AtDB - Arabidopsis thaliana genome database TAIR - The Arabidopsis Information Resource MATDB - MIPS Arabidopsis thaliana db TIGR AtGI - TIGR Arabidopsis thaliana Gene Index AGR - Ara

59、bidopsis Genome Resource,Plants,BeanGenes - Beans genome db （豆） BeanRef - Beans genome db and other resources ChlamyDB - Chlamydomonas reinhardtii genome db衣藻(分類地位有爭(zhēng)議的綠色雙鞭毛單細(xì)胞生物) CropNet - Genome mapping in crop plants CottonDB - Cotton genome db （棉花） MaizeDb - Maize genome db （玉米） INRA Maize - INRA Maize genome db ZmDB - Maize genome database Pisum sativum (pea) web site（豌豆）,Plants-Rice,RGP - Rice Genome Research Program RiceGenes R - Monsanto rice genome site TIGR OsGI - TIGR Rice Gene Index TIGR GmGI - TIGR Soybean Gene Index Snapdra