細(xì)胞連接與細(xì)胞粘連.ppt

1、第七章 細(xì)胞連接與細(xì)胞粘連,Cell junction and cell adhesion,第一節(jié) 細(xì)胞連接 cell junction 1、 封閉連接 Occluding junction 2、錨定連接Anchoring junctions 3、通訊連接Communication junctions 第二節(jié) 細(xì)胞粘附分子 cell adhesion molecule,1、Occluding junction (tight junctions) 2、Anchoring junctions （1） Actin filament attachment sites a. Cell-cell adhe

2、rens junctions (adhesion belts) b. Cell-matrix adherens junction (focal contacts) （2） Intermediate filament attachment sites. a. Cell-cell (desmosomes) b. Cell-matrix (hemidesmosomes) 3、Communication junctions （1） Gap junctions （2） Chemical synapses,Three types of Cell Junctions:,閉鎖連接(occluding junc

3、tion) ：緊密連接(tight junction),The Tight Junction Forms Barrier Across Cells Despite the many structural and biochemical difference among various types of epithelia, all have the function of being selectively permeable to fluids on each side.,The Tight junction play two distinct roles in this selective

4、 barrier function. Prevent the apical membrane proteins from moving to basolateral surface. Seal the spaces between epithelial cells to prevent so that molecules can not move between cells.,desmosome,電鏡下顯示細(xì)胞間連接橋粒,通訊連接(communicating junction)：是細(xì)胞間的一種連接通道，除了使細(xì)胞間相互連接外，還介導(dǎo)細(xì)胞通訊，包括：（1）間隙連接(gap junction)；,

5、（三）,化學(xué)突觸(chemical synapse) ：由突觸前膜、突出間隙和突觸后膜組成，信息的傳遞需要有傳遞物（如神經(jīng)遞質(zhì)）,Legend:When an action potential reaches a nerve terminal, it opens voltage-gated Ca2+ channels in the plasma membrane, allowing Ca2+ to flow into the terminal. The increased Ca2+ in the nerve terminal stimulates the synaptic vesicles to fuse with