乳酸分析在臨床中的應(yīng)用

1、沃芬醫(yī)療 張浩葡萄糖蛋白質(zhì)脂肪 葡萄糖的代謝產(chǎn)物能量單位(ATP)反應(yīng)地點(diǎn)有氧代謝水+二氧化碳36線粒體內(nèi)無氧代謝乳酸2線粒體外線粒體結(jié)構(gòu)模式圖細(xì)胞漿細(xì)胞漿糖元糖元-葡萄糖葡萄糖-丙酮酸丙酮酸 2ATP 乳酸乳酸無氧糖酵解無氧糖酵解有氧糖酵解有氧糖酵解線粒體線粒體O2 CO2 H2O 36ATP三羧酸循環(huán)三羧酸循環(huán)Jan B,Philippe G, Michel C,et al. Serial blood lactate levels can predict the development of multiple organ failure following septic shock J.A

2、m J Surg,1996,171(2):221-226 Henning R J，Wei M N Weiner F. Blood lactate as a prognostic indicator of survivial in patients with acute myocardial infarction.Circ Shock,1982,9(3):307Rashkin MC,Bosken C, Baughman RP. Oxygen delivery in critically ill patients :Relationship to blood lactate and surviva

3、l. Chest,1985,87(5):580J Inflamm(Lond) 2010;7:6Munoz R,Laussen PC, Palacio G, et al.Changes in whole bloodlactate levels during cardiopulmonary bypass for surgery for congenital cardiac disease an early indicator of morbidity and mortalityJ Thorac Cardiovasc Surg,2000,119：155一162. 心內(nèi)直視手術(shù)病人的乳酸監(jiān)測(cè)付利民等

4、：實(shí)用兒科臨床雜志2004，19（7），576578 Kruger K, Hallberg B, Blennow M, et al. Predictive value of fetal scalp blood lactate concentration and pH as markers of neurologic disabilityJ. Am J Obstet Gynecol,1999，181:1072-1078.圍產(chǎn)兒的乳酸監(jiān)測(cè)Mathieu Gatien,MD Ian Stiell,MD,et al.Diagnostic Performance of Venous Lactate on

5、 Arrival at the Emergency Department for Myocardial Infarction. Academic Emergency Medicine.2005 12(2):106-113Coast TJ,Smith JE, Lockey D,et al.Early increase in blood lactate following injuryJ.JR Army Med Corps,2002,148(2):140-143夏紅杰 王 潔 現(xiàn)代醫(yī)藥衛(wèi)生2004年第8期1 李春盛，顧偉等。充血性心力衰竭患者循環(huán)內(nèi)皮細(xì)胞、血乳酸和一氧化氮濃度的變化J。中華急診醫(yī)學(xué)

6、雜志，2005，14（4）:313-315線粒體結(jié)構(gòu)模式圖齊多夫定(zidovudine)和司他夫定(stavudine)Astles R, Williams CP, Sedor F. Stability of plasma lactate in vitro in the Presence of antiglycolytic agents.Clin Chem 1994,40:1327-1330 Sacks DB. Carbohydrates. In Tietz Textbook of Clinical Chemistry,3rd ed.Burtis CA, Ashwood ER,Eds. Ph

7、iladelphia, Saunders, 1999,pp787-789 GEM Premier 3000pH, PCO2, PO2, Hct, Na, K, Ca, Glu, Lac第一臺(tái) pH/血?dú)夥治鰞x 1959 IL105血氧定量計(jì)1967 - IL182將動(dòng)脈血?dú)夥治鰞x引入常規(guī)的臨床檢測(cè)發(fā)明了第一臺(tái)血氧定量計(jì)用火焰光度計(jì)來測(cè)量電解質(zhì)實(shí)現(xiàn)智能質(zhì)量控制管理（iQM） 性能可靠 多年的臨床應(yīng)用經(jīng)驗(yàn)iQM一體化分析包THb, O2Hb, CO2Hb, MetHb(plus cO2sat and O2cont)PT, APTT, ACT, ACT-LR操作簡(jiǎn)便、免維護(hù)靈活的檢測(cè)項(xiàng)目組合是IL的經(jīng)典之作 Ca+(7.4)* HCO3- HCO3std TCO2 BEecf BE(B) SO2c THbc O2ct O2cap A-aDO2 pAO2 paO2/pAO2 RI CaO2 CvO2 CcO2 a-vDO2 Qsp/ Qt P50BP(mmHG) 760BE & Temp-corrected Equations NCCLSP50 Calculation Parameter SO294君子生非異也，善假于物也。君子生非異也，善假于物也。登高而招