分泌型卷曲相關(guān)蛋白5、長(zhǎng)鏈非編碼RNA人肺腺癌轉(zhuǎn)移相關(guān)轉(zhuǎn)錄本、脂肪因子網(wǎng)膜蛋白-1在妊娠糖尿病患者中的表達(dá)及其對(duì)妊娠結(jié)局的預(yù)測(cè)價(jià)值.docx

1、MR«Be.?402切&舌t有£及卷可米位巷蜀J.中藥43<il:H5H9.6|SI5.?8.ft$.§.«JIt1iATflSTAT3博玉R弟照弟2019.48I31:253257.71段#壬i1?.r?i«M8?.MSTPCiS|正苗白取幽艮R|l.南J.中田位敏長(zhǎng),錄古，2018,28(121；3237.8.KenlerJ,HokmannT.GUlHerA.ttal.Radiosensitiiatiouandietiaggressivephenojptofhuminmil'gnanij.iomacellsexpres

2、jing:jocilrtitdehNrogenwI1DH1mnlanlpro:en：dissectingthemecksn:sms.J：.Can”Base.2919,116:SS9.(91弓笊元，局佑，售隹E3.宿氏R岳療后立耳&U咎療官登庭$eMnJMft1IMM.2006181：535536.iIiD球甫：|j來大牝2018.11FarrowES.BollingerT.WojcikT.elil.Migneticresonanceimungandcomput*diomographyiotheiSKijmen；ofmindibuarinm.onbysqsmuiBcelltncinoma

3、oftieon.csriiy.InllDtnteonsurgicalminigemenlandpostaperaiitttour$rI'.ReiSlomi:«.ChirMixil.olicChirOitlt.2016,U7lSI；311321.112SKOVJSSO&亡的彩啟).中藥W評(píng)與§*藥專，2020,31(21:125133.13美*甫，號(hào)子fib版吳，務(wù).木厚章£角人舌黃K為電£T”S113切MtRMa5；1r.中SftftS?II.2020.301Hl：16,HiChenYZ.BtiN.BIH,etiPropimololinh

4、ibilitheproJieralion,m:gri.ionand.ubeformaiionofhemtngiomi<t.$hroigbH1FIadependen*mechiniims(J.BrtziIMedBi»lRes.2017,5012'"613$15：HnLJ,JiangT,WingFI.e!il.Ef:tct!olirletunittcombinedwillbor'ezomibonipopiositandaulophanofi(u：emye.oidleukemiate!ItinvitroindiumtchiaijmI.ZhonghoiXieY

5、eXueZaZhi,2019.4013)：204208.16)壬居酉邛il有，王導(dǎo)E3.青SH屋U尊居小艮居窗K枝敏朗t»F“，Bel25gMOfi(J,(Is'方長(zhǎng)。大學(xué)學(xué)枝，2020.40(il：93H.I17VEGFMBel2.«1HOfiMSCt2H9.U(lll：15“1545.ISiX«W.GuoG.LiJ.etsi.AclintionofBel2ctspase9apoptosiiptbv2yinIheleslisolislhmtlicmice：J.PLoSOne.2016.11131:eO149353.IftMI：202108Oli如科與生殖

6、醫(yī)學(xué)RNA人肺腺癌1在妊娠糖尿病DOI：10.3969j.issn.16721993.2021.11.029分泌型卷曲相關(guān)蛋白5、長(zhǎng)鏈非編碼轉(zhuǎn)移相關(guān)轉(zhuǎn)錄本、脂肪因子網(wǎng)膜蛋白患者中的表達(dá)及其對(duì)妊娠結(jié)局的預(yù)測(cè)價(jià)值鞠佳ft）0大學(xué)附屬長(zhǎng)沙市舊幼保俚院歸產(chǎn)科，長(zhǎng)沙410007【步夏I目的分於型卷由相關(guān)蚩白5（SFRP5），長(zhǎng)8豐考同RNA人曲俄導(dǎo)*移招關(guān)樣錄本IIncRNAMALAT1If用9子且艮策白HOmeniinII在托免特艮希GDM）患者中的表反其N威氐綣局的預(yù)刈價(jià)值。方法前麾住延敏2020年1月至20211月湖南的慈大學(xué)附屬長(zhǎng)汐市0幼保健院診治的194例GDM思者作為研完對(duì)象（GDM組）.另

7、選取同期湖南帥范大學(xué)附屆長(zhǎng)沙市如幼保健院族收的194例體桂濱鼠單舊*為N址，費(fèi)定曲魏SFRP5.Omentinl米平及IncRNAMALAT1裘井貧，分折SFRP5.lncRNAMALATl.Omentin1KGDM&廢扃的用浦價(jià)值，穿臬與N明貝比故，GDM坷it帶IncRNAMALAT1.Omeniin1水平放江，差異只肖電計(jì)學(xué)直ZIPD051：與毋爰嘗比段，重度,血清SFRP5.IncRNAMALATl.Omeniin1米平放成讀#只有電計(jì)孕食R（PU051,虞建jfi不良if克翁耳發(fā)生事甲顯有于孫明資0多因案Logilic目白筷型分訴君果顯"SFRP5.IncRNAMA

8、LATl.Omeniin1是必電不R任資監(jiān)晝發(fā)圭的白世困索（P。5、與單組SFRP5.IncRNAMALATLOmeniinI比該，三項(xiàng)親合時(shí)母板貨局的故劇步帶更高IP。05）.君西GDMf|iSFRP5、IncRNAMALATl.Omeniin1米平肉低于他原其不良此板曲骨曲總有帝精tl童而詢加，I關(guān)建討I分#型由著機(jī)關(guān)笛白5：非K修弭同RNA：有甘困子同H番白1普著敏另宿；成板君昌【中國(guó)分類號(hào)】R714【文獻(xiàn)長(zhǎng)識(shí)仍】A|為iR乍吉)8ft8Email：jnl68163comExpresiionofsecretedfrizzledrelatedprotein5.longnoncodingRN

9、AIramcriptsiuociatedwithmelasta$isinhumanungadenocarcinomaandadipokineretinalprotein1ingesialionaldiabet”mellitmandlheirpredidivevalueforpregnancyoutcomeJUJiasuiA,YlMin.DtparlmenlofObstetricsandGyneco.ogy.ChangshaMaternalandChi.dHealthHospitalAHiliattdtoHunanNorma!Uninrjity.Changsha410007.Hunan.Chin

10、arelatedprolein5(SFRP5).longno；IncRNAMALATU,idipokinerelinandtheirpredidirevilueforprenaHeiltbHospililAffiliatedtoHuninNIAbstract!0bjecIiveToinvesligilelheexpreuionolsecreiedfrizzledncodingRNAIrinscriplsusociaitdwthmelislniiinhumanlungNenocirtinomaalprolein1Omentin11inpilieDHwithgesialionaldiabetesm

11、ellilDi<GDMncyoincomes.Methods194pitienhwiihGDMinChangshaMaternaltndChildRejultjComparedwilblhecontrolgroup,sP<0fl5).Compiredwiihmildgroup-leregroupsP<005),TheincidenceofadvenecontrolgroupandmildgroupP<0051.MMALAT1andOmentin1wereriskfactorsforRejultjComparedwilblhecontrolgroup,sP<0fl5

12、).Compiredwiihmildgroup-leregroupsP<005),TheincidenceofadvenecontrolgroupandmildgroupP<0051.MMALAT1andOmentin1wereriskfactorsforormdUniversityfromJmuiry2020IoJanuary2021wereprojpetlivelyjeleetedissubjecti(GDMgroupi.Iniddilion.194healihypregnm!womenIromlhesamehospililwerejelectedmthecontrolgrou

13、p.ThelevelsolSFRP5tndOmentin1andlheexpressionlerelofIncRNAMALAT1inlhetwogroupsweremeasured,andthepredictivevalueolSFRP5.IncRNAMALAT1andOmenlinlforGDMprepancyoultomewasanalyzed,erumIncRNAMALATImdOmenlin1levelswerelowerinGDMpoupI$ofjerumSFRP5.；ncRNAMALAT1"dOmentiniwerelowerinseverepregntncyoutcom

14、esinseteregroupwnsignificantlyhigherthinthatinullivriateLogisticregreuionmodelanslniishowed:hatSFRP5,IncRNAadvenepregnancyoutcomes(P<005).ThecombinationolSFRP5.IncRNAMALAT1andOmentin1hadbijhefpredictiTevaluelorpregnincyoutcomethanthethreetlone(P<005).ConclusionsThelevehofserumSFRP5.IncRNAMALAT

15、1andOmentin1inGDMpalienlswerelowerthanthoseinhealihypregnaniwomen,indtheadvenepresnantyoutcomesincreisedwithlheseverilyo:patients.【Keywords)Secreledfriuledrelatedproiein5：LongnoncodingRNA：Adipokineretinilproiein1；Ges13lionildiabetesmellilus：Pregnintyoutcomes££ISI(geilitiomldiabetesmellitus

16、.GDMI作為著勤特有發(fā)瘍，主要括好嵌發(fā)生后孕加博代說產(chǎn)生異常所放的播尿I!IS：.白5($ecreledfrizzledrelaifdprotein5.SFRP5I亦為酉型瓦奏信蒞由子，具有百節(jié)fl基，精虬博島索困族性作用，在展島索抵抗發(fā)生中發(fā)掉重要茴義；而E盼目子間長(zhǎng)是白1(adipokineretinalproteinI,OmenlinlI郵國(guó)賽赫志桐在GDM患音祁血中存在異常隸達(dá)，是誘發(fā)GDM發(fā)生的危險(xiǎn)因素，但其具體臨床意義需進(jìn)一步研究證實(shí)。長(zhǎng)錐非,碼RNA人肺爆盛轉(zhuǎn)移相關(guān)轉(zhuǎn)錄本(longnoncodingRNAIrtnscriptsasociBtedwiihmeiutasisinhu

17、manlungadenocarcinoma,IncRNAMALATI),pJJ茉錄及特錄后f頁(yè)上if1因表弦進(jìn)行訝在，其表達(dá)與心H曾發(fā)知麝等多片獲京的反蟲、發(fā)展具有巒場(chǎng)股條'七定GDM患者血流SFRP5.IncRNAMALATI,OmentinI表西，分析其對(duì)憑娘蒲局的預(yù)洲價(jià)值。1用象與方法11尿兄對(duì)象前瞻性遺取2020年I月至2021年1月湖甫師海大學(xué)時(shí)屬長(zhǎng)沙市好幼保俺院診治的194例GDM患者作為研咒對(duì)象(GDMSI»年售藏圍？23。八年甘261±33|£,技霸中學(xué)醫(yī)學(xué)會(huì)中的彥世標(biāo)在幻GDM強(qiáng)分為&建址In=911與堂食級(jí)In=H3l豹人麻他：

18、有臺(tái)中華民？§IlK克合并/屎布彥fiM：li您&在有臺(tái)空&血息FPG;N5immolL.lhilI>1Q0mmolL.2hA扈N85mmolL中任-林4；草畿娠。排除標(biāo)準(zhǔn)：合并心、肺、肝、骨等重要陟器功能不全；合并妊娠高血壓及其他妊娠期并發(fā)整；經(jīng)產(chǎn)如或高齡產(chǎn)婦；合并腳箱；孕前存在高血壓、德尿鋼、甲亢等慢性疾摘：©合并總英、內(nèi)分洛獲?。唤凵袼貋y、敏識(shí)隨畀。另選果同期滿南曲葩大學(xué)附屬長(zhǎng)汐市日幼保健院接收的194啊體冶健康孕h#為升爵址，年依慝局203?羅年會(huì)I26I±5QW,Wf兄經(jīng)湖南師藏大學(xué)附成長(zhǎng)沙市自幼保健辰陷理委員會(huì)批準(zhǔn)，孕筋家,&qu

19、ot;髯歐同麝，2無累宿標(biāo)丹攻攵推堂愎、餐后2bO5mL.2000rm:n肖It030min.一$QC環(huán)枝備用，H蒂FPG,餐后2h11I(2hPG).IittilfIHbA.J呆用全白彼I Hift南京貝竟民療EW有艮公司；整號(hào)：龍瑞B(yǎng)S280i|行倉(cāng)HM眼原島素(FINS；果用化學(xué)發(fā)光蒼頁(yè)利#1上宙)西門子長(zhǎng)學(xué)彥并產(chǎn)有隋公司&黑，商戒&度畋用試*法檢H慎島。圳曲切能麻HOMApl.SFRP5、OmeniinI水甲武劑盒回自賽默飛世爾科技(中國(guó))有戚公司，快作件格枝景試劑MJfl.賣時(shí)表光定雖芝號(hào)錄聚合償佳反(5IRTqPCRI蒞廿*ncRNAMALAT11ii.ft用Pri

20、merS0ItOit51采用2母Sif|,MU6,1 3發(fā)計(jì)學(xué)處理采用SPSS2。軟件對(duì)相關(guān)敏據(jù)進(jìn)行絞it分析。計(jì)量資&呆用伐知戲妲標(biāo)淮差(魄$)禎；計(jì)!H找用X?魅，MS(S分宜1時(shí)|衷示；PC。05表示差異月有電并宜義，2菇果1兩紙血糖、鹿島素水平比坂5.計(jì)照站比故，GDM級(jí)H浦FBG、2hPG,HbAloFINS術(shù)甲故有.HOMA平敏氏，茬導(dǎo)只有琛計(jì)學(xué)京義IPCD051.具體結(jié)果律見表1<如其員頊K5f*flt«s)員SJ«HFBGmmomL2hPGmmomLHbA,c%FINSHOMA。GDM組194682+0871051+190683il2153S+

21、042394+0$7時(shí),組194401±054620±i16480±03T390+067180Hill53til38220269702235026070109200P值0001000100010001000122再址H浦SFRP5.IncRNAMALAT1,Omentin1米平比放GDMgflitSFRP5.IncRNAMALATi.OmenlinUfftffl.ISFRP5.IncRNAMALATLOmenlin1由平放k,差異具有悠計(jì)學(xué)宜R，：P<。Q5i,其*君果Q袤2=23SFRP5、IncRNAMALATI、Omentin1*平與GDMIt11蜀、

22、麟島索指標(biāo)的相關(guān)性分析SFRP5、IncRNAMALATI.Omentin1與GDM勇者FBG.2hPG.HbA.d|fl關(guān)(P<005),SFRP5,IncRNAMALATI,Omenlin1與GDMl者FINS,HOMApIJO(P<005l.具體結(jié)果詳見表3,24三照不良如煤局發(fā)生舉比墳重既用不艮機(jī)坂穿月發(fā)生率(2330%.24103高于甘陽(yáng)級(jí)1412%.81941圳里度現(xiàn)I1208%,II911,是#其有家計(jì)學(xué)壹乂1P<0051.25不良妊廢皓局發(fā)生散電園索的多元Logistic回臼分析得不艮如岳君局發(fā)主/度=0,中重度=IIM.咨SFRP5.IncRNAMALATI

23、.Omenlin】作為自變八段自升冒役為1,正常我為0,切入二分類多0索Logistic目0修單分Hi,狀顯示,SFRP5,IncRNAMALATI.OmentinI為最府不艮兼定毓戔生MI(P<0051.I(U1M14,26ROC由費(fèi)分KSFRP5,ImRNAMALATI、Omenlin1及三次暖合對(duì)處娠若局的故洲價(jià)值與SFRP5.IncRNAMALATI.Omenlin1*1,三須底會(huì)彌腰募局的我H價(jià)修敏高(PM051<具修君臬洋殳表5§1.表2丙壩山育SFRP5,IihRNAMALAT】，Omenlin】*早It鼓碓H項(xiàng)0AUCZPfClt«lfE(%)特

24、異度(%)95%ClSFRP50736225?00041697895790440596T877n:RNAMALATI074S230300021*4884293470614-08$3Omeniin!076$22960(0128974903189860639-0MT三項(xiàng)聯(lián)合0$3426110001一9697843307250942項(xiàng)0AUCZPfClt«lfE(%)特異度(%)95%ClSFRP50736225?00041697895790440596T877n:RNAMALATI074S230300021*4884293470614-08$3Omeniin!076$22960(0128

25、974903189860639-0MT三項(xiàng)聯(lián)合0$3426110001一9697843307250942表5ROC由菠分折SFRP5,IncRNAMALATI.Omenlin1艮三見艮合Wif有蕓目的&洲價(jià)故1OO-特異度1IROCMMSFRP5.IncRNAMALATi.OmenlinI反三匝聯(lián)合甘局的川iHili3討論臨床研充表明，受經(jīng)濟(jì)變化、生活方式等因素影響，GDM發(fā)生凡險(xiǎn)逐籽升高，對(duì)母晏安全造成產(chǎn)重成脅，因此，預(yù)防及降KGDMgtAt,tfM：7，；.本研咒結(jié)果顯示，GDM鬼者血清SRFP5水平明星低于他康孕婦，由此提示SFRP5可能參與GDM的發(fā)生'發(fā)展，SFRP5

26、洋為Wn3號(hào)詢質(zhì)由技信衣列，可時(shí)圳四分L成博及宙,號(hào)多沖筋私部居產(chǎn)生分導(dǎo)換果e，研充京用，Wn雋號(hào)其卻LRP5突變是及糖藏發(fā)生的重要觥田素，而SFRP5可甘Wni經(jīng)R官號(hào)其留產(chǎn)生如例，進(jìn)而發(fā)H焉島索換史費(fèi)果，OR5IIM：，12：用關(guān)學(xué)者宥出，GDM勇者SFRP5也8#&$FRP5：ngmL)M:RNAMALATIOmemiu1GDMQ911335±447090+02621534±3414重度虹103934+275071±02019897i285J對(duì)照毋194224Sf553I03±03133T45xH14Fg19$407135337HOPtt0

27、00100011HlI3SFRP5.ncRNAMALATi.OmtnlinUfGDM«.I血糖、胰島素指標(biāo)相關(guān)指標(biāo)的相關(guān)性分析SFRP5in:RNAMALATIOmtn:n1IhIfr值PIrtPlrp值FBG-05120001-04180023-04i50B)2bPG-0310001-04030018-0348i02HbA.-0215001-«4490042-04190019FINS0847003405170001flS640028HOMAB03160041091400010$160Oil表4不艮任&目線生修懶®紊的多元Logistic96#U水平代于他

28、親芋園，并與血德、，慎島素存在相關(guān)性，由此，SFRP5可七為ffftGDMO$I?tft，3U本W(wǎng)*藥杲顯M，GDM走者外國(guó)J11SFRP5水平呈異常高表達(dá)，且簡(jiǎn)歡箱進(jìn)展逐瀟降R,提示SRFP5參與GDM的發(fā)生發(fā)暖過程，與相關(guān)研光內(nèi)容相帝：，HOt§OJj分折或亂，GDM董方不良質(zhì)胃君局發(fā)生率皎高，證實(shí)SFRP5與GDM、不良扯娠托娠菇局的發(fā)生存在必要關(guān)扇.誼男刈定SFRP5對(duì)族竟GDM愚戢娠結(jié)荷具艘敏義。0IMBtlaSEWa.1PfiOR95%(：lSFRP520604169400010711。51-167IncRNAMALATI1S50375870001084048-178Om

29、tnlin1I37061716000106I043-151W兄表明，IncRNAMALATI在2冬摘依帝勇者外®H中呈異常隊(duì)達(dá)，口挪關(guān)微血管功能障丹房理過程中發(fā)作頁(yè)要作用：lt：.用關(guān)吊另表珥，GDMS*h青IncRNAMALAT!表*普低，H與HbAL存正相關(guān)性，而HbAh可有效反映血箱檢制程度茂基H米平，血比證實(shí)，GDM發(fā)生、發(fā)，中IncRNAMALATI上調(diào)發(fā)擇保護(hù)作用，但是否可作為GDM軫斷及任娠落局1¥估常IfMIit-MV,l4：«Omentin1只有物奏活，處果，可對(duì)炎癥反應(yīng)的為成澈話產(chǎn)生IS棉效果,井札H島索并導(dǎo)發(fā)HM:，H；.K8.GDM*tIn

30、cRNAMALATI.Omenlin1米平放&,由ftff$IncRNAMALATI.OmenlinI參與GDM的生皇有理垃E,同Hill眼弟局進(jìn)行分折發(fā)現(xiàn)，GDM思者不良冥娠始局發(fā)生率牧商，I殖軟加重號(hào)血，由此靈示IncRNAMALATI、Omentin1與GDM.不良虹照好僑紿局的發(fā)生存在也要關(guān)聯(lián)。il過JI其水平進(jìn)行檢8,對(duì)預(yù)湄GDM患者此垢引局具有他特意義，本研克對(duì)上述將麻及償Rd診行分折反現(xiàn)，SFRP5,IncRNAMALATI.Omentin1我合檢洲對(duì)GDM勇者妊娠，扃的價(jià)It甲是高于申.一描麻檢利，由此表明指場(chǎng)族合檢利對(duì)應(yīng)低不良好娓卷局的發(fā)生具有重要崽義。除上訴述，GD

31、MfflitSFRP5,IncRNAMALATI.Omen1水平均低于健俄華歸，fl其不RJJ版菇局鹿崽者摘摘m重而博M,參考文贏1 費(fèi)交卷，為再與，刁段苴，等.北集月菖艮每，&$現(xiàn)有血氏龍麻皂專孕E制i&民i世子、D二苗水¥燮11女這義IJ.tSflftR«2020.351：4345.2 PlowsJF.StanleyJL.BikerPN.etil.Thepj'bophniologjofjetUtiooaldiibetesmdlilnsiI).IntJMolSci.2018-19iIII：3342.I32420.35I4)：623626.41ACO

32、GpritiitibulltlinNo.190：jesmiona.diibetesmelliiDi1J.ObilelGrnecol,2018,131121：t49e64.5：DinS.PheifferC.AbrihimiY.elil.Moleculirbiomirkeislorgetlalionaldiibeiesm«llilMlI).IntIMolSci,2018.19101:2926.I6)中車長(zhǎng)學(xué)會(huì)白F&學(xué)分會(huì)F&學(xué)址，中生氏學(xué)會(huì)留產(chǎn)氐學(xué)分箴缶臺(tái)井萱果帛每乍坂.其垢合井食艮帛彥治若有1?0141J.中宰旦*麻親古，2”4,49(81：561569.7)HomiyonniA.Bt