鼻咽腫瘤 頸部淋巴結(jié) 誘導(dǎo)化療 毒副作用 多西他賽 順鉑 CT-sim TPS

1、鼻咽腫瘤論文：TP方案誘導(dǎo)化療對、a期鼻咽癌頸部淋巴結(jié)消退作用及安全性的臨床觀察【中文摘要】觀察TP方案誘導(dǎo)化療對、a期鼻咽癌頸部淋巴結(jié)消退作用、毒副反應(yīng)發(fā)生情況,評價TP方案誘導(dǎo)化療的有效性、安全性。方法：36例經(jīng)病理及影像學(xué)證實的、a期鼻咽癌行多西他賽(TXT)十順鉑(DDP)誘導(dǎo)化療1周期,TXT75mg/m2,d1,DDP100mg/m2,d2-3。誘導(dǎo)化療前一天、誘導(dǎo)化療結(jié)束后(放療開始前)分別行CT(西門子CT-模擬定位機siemens somatom emotion duo2003)掃描,用TPS(Pinnacle 7.4f)勾畫CT掃描頸部淋巴結(jié)、計算體積,前后兩者對比。誘導(dǎo)化

2、療前、結(jié)束后1天、結(jié)束后1周分別檢測血常規(guī)、T淋巴細(xì)胞、肝腎功,觀察胃腸道毒性等毒副反應(yīng)。采用SPSS17.0版統(tǒng)計軟件分析,采用配對t檢驗比較誘導(dǎo)化療前、后36例患者頸部淋巴結(jié)體積變化情況,誘導(dǎo)化療前、結(jié)束后1天、結(jié)束后1周白細(xì)胞、中性粒細(xì)胞、紅細(xì)胞、CD3、CD4、CD8、CD4/CD8變化情況,P0.05為差異有統(tǒng)計學(xué)意義；采用單個樣本t檢驗分析T淋巴細(xì)胞與正常值差異,P0.05為差異有統(tǒng)計學(xué)意義。結(jié)果：CT結(jié)果顯示誘導(dǎo)化療結(jié)束后頸部淋巴結(jié)體積有明顯縮小,平均縮小7.57.【英文摘要】:To observe the lymph nodes regression of、a nasophar

3、yngeal carcinoma(NPC) and adverse effect and toxic effect of inductive chemotherapy, evaluate the effectiveness and safety of TP program.Methods:From June 2010 to October 2010,36 patients with locally、a NPC were accepted by Department of First Affiliated Hospital of Guangxi Medical University,all th

4、e patients accepted TP(TXT+DDP) program inductive chemotherapy 1 cycle, TXT75mg/m2, d1, DDP100mg/m2, d2-3.The lymph nodes of neck were tested b.【關(guān)鍵詞】鼻咽腫瘤 頸部淋巴結(jié) 誘導(dǎo)化療 毒副作用 多西他賽 順鉑 CT-sim TPS【英文關(guān)鍵詞】nasopharyngeal carcinoma(NPC) lymph nodes of neck induction chemotherapy TXT DDP adverse effect and toxic effect Siemens CT-sim TPS【索購全文】聯(lián)系Q1：138113721 Q2：139938848【目錄】TP方案誘導(dǎo)化療對、a期鼻咽癌頸部淋巴結(jié)消退作用及安全性的臨床觀察摘要4-6ABSTRACT6-7前言8-12材料與方法12-14結(jié)果1