早產兒低蛋白血癥

1、.早產兒低蛋白血癥顏衛(wèi)源 2016-03-16.12為早產兒輸注白蛋白能否獲益3擴展：生后第1天總蛋白水平與早產兒結局相關目錄早產兒白蛋白水平.早產兒白蛋白水平 Reading R F, Ellis R, Fleetwood A. Plasma albumin and total protein in preterm babies from birth to eight weeksJ. Early Human Development, 1990, 22(2):81-87. Miller P W. Serum albumin concentrations and oedema in the ne

2、wborn.J. Archives of Disease in Childhood, 1986, 61(7):657-60.早產兒白蛋白水平61 preterm babiesReading R F, Ellis R, Fleetwood A. Plasma albumin and total protein in preterm babies from birth to eight weeksJ. Early Human Development, 1990, 22(2):81-87.早產兒白蛋白水平61 preterm babiesReading R F, Ellis R, Fleetwood

3、 A. Plasma albumin and total protein in preterm babies from birth to eight weeksJ. Early Human Development, 1990, 22(2):81-87.早產兒白蛋白水平61 preterm babiesReading R F, Ellis R, Fleetwood A. Plasma albumin and total protein in preterm babies from birth to eight weeksJ. Early Human Development, 1990, 22(2

4、):81-87.早產兒白蛋白水平195 infants of 25 to 42 weeksMiller P W. Serum albumin concentrations and oedema in the newborn.J. Archives of Disease in Childhood, 1986, 61(7):657-60.早產兒白蛋白水平早產兒白蛋白水平應當大于20g/L,35周左右達到25g/L,39周左右達到30g/L.為早產兒輸注白蛋白能否獲益 Jardine LA, Jenkins-Manning S, Davies MW. Albumin infusion for low

5、 serum albumin in preterm newborn infantsJ. Cochrane Database of Systematic Reviews, 2004, 3(3).為早產兒輸注白蛋白能否獲益 結論 尚缺乏有力的證據(jù)去證明為存在低蛋白血癥的早產兒輸注白蛋白能夠改善死亡率，但同樣沒有足夠的證據(jù)指出白蛋白有顯著的副作用。.入選文獻的白蛋白水平have a plasma albumin level below 30 g/L at 48 to 72 hours of life。Study subjects were newborn infants who were venti

6、lator dependant at less than seven days of age and had a serum albumin level of 30 g/L low birth weight newborn infants at risk for respiratory distress who were acidaemic with a low total serum protein level (whether they were hypoalbuminaemic or not is unknown).僅有僅有3篇文獻入選篇文獻入選.為早產兒輸注白蛋白能否獲益 早產兒早期，

7、小于30g/L即輸注白蛋白不一定能獲益.總蛋白水平與早產兒嚴重不良結局相關 Silvia I, Francesco B, Catherine Q, et al. Total plasma protein in very preterm babies: prognostic value and comparison with illness severity scores.J. Plos One, 2013, 8(4):e62210. 761 infants were studied(total protein level of less than 40 g/L),plasma protein

8、measurements on day one of life in very preterm infants severe adverse outcome：This was defined as death or severe (grade 3 or 4) intraventricular hemorrhage or cystic periventricular leukomalacia occurring before infants discharge from hospital. Conclusions: Early hypoproteinemia has prognostic value for severe adverse outcome in very preterm, sick infants. Total plasma protein has a predictive performance comparable with CRIB and SNAPPE-II and greater than other validated severity scores.12早產兒早期，小于30g/L