肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述課件

1、肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述1The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma徐徐 智智南京醫(yī)科大學(xué)附屬南京第一醫(yī)院暨南京醫(yī)科大學(xué)附屬南京第一醫(yī)院暨南京市第一醫(yī)院南京市第一醫(yī)院 腫瘤腫瘤(zhngli)內(nèi)科內(nèi)科第一頁(yè)，共十四頁(yè)。肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述Worldwide incidence of HCCBlum HE, Spangenberg HC. Arch Iran Med. 2007 Jul;10(3):361-71.第二頁(yè)，共十四頁(yè)。肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述

2、Identification of Yes-associated Protein (YAP)Zender, L. et al. Cell 125, 1253-67EFGH第三頁(yè)，共十四頁(yè)。肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述YAP improves cell proliferationTime (Days)*：p0.05。 第四頁(yè)，共十四頁(yè)。肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述YAP induces anchorage-independent growthMIHA-YAP cells but not MIHA-Vec could form colonies in soft-agar.第五頁(yè)，共十四頁(yè)。

3、肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述MIHA-YAP cells gained advantages in cell migration and invasion.YAP enhances cellular mobility and invasiveness第六頁(yè)，共十四頁(yè)。肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述IHC results of YAP in HCC53.7% HCC samples showed nuclear YAP positive.第七頁(yè)，共十四頁(yè)。Clinical association of nuclear YAP in HCC第八頁(yè)，共十四頁(yè)。肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述C

4、linical association of nuclear YAP and HCC-specific postsurgical recurrenceKaplan-Meier Median RFT：Nuclear YAP negative: 25.8 months vs. Nuclear YAP positive：12.9 months第九頁(yè)，共十四頁(yè)。Nuclear YAP is an independent prognostic marker for HCC recurrenceCox Regression 第十頁(yè)，共十四頁(yè)。肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述SummaryYAP confe

5、rs tumorigenic and metastatic potentials in hepatocytes, as evidenced by enhanced aptitudes in cell viability, anchorage-independent growth, migration and invasion. YAP nuclear accumulation was found in the 53.7% of HCC, correlated with poorer tumor differentiation and higher serum alpha-fetoprotein

6、 (AFP) levels. Nuclear YAP is an independent predictor for HCC-specific recurrence-free survival. YAP plays an important role in HCC development and progression. 第十一頁(yè)，共十四頁(yè)。肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述Acknowledgement 新加坡國(guó)立大學(xué)外科系和藥學(xué)系新加坡國(guó)立大學(xué)外科系和藥學(xué)系 Asso. Prof. John M. Luk香港大學(xué)外科系香港大學(xué)外科系 Prof. Fan S. T.，Prof. Poon R. T. and Surgical Tissue Bank 南京市第一醫(yī)院腫瘤南京市第一醫(yī)院腫瘤(zhngli)內(nèi)科內(nèi)科 第十二頁(yè)，共十四頁(yè)。肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述第十三頁(yè)，共十四頁(yè)。肝細(xì)胞癌中表達(dá)-南京醫(yī)科大學(xué)綜述內(nèi)容(nirng)總結(jié)The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcino