組胺和抗組胺藥課件

1、南開大學(xué)(nn ki d xu) 醫(yī)學(xué)院張京玲 王侃 代紅勝第一頁，共三十一頁。第二頁，共三十一頁。第三頁，共三十一頁。第四頁，共三十一頁。Histamine and Antihistamine AgentsHistamine and its agonistsHistamine antagonistsH1 receptor antagonistsH2 receptor antagonists第五頁，共三十一頁。 Together with endogenous peptides, prostaglandins and leukotrienes, and cytokines, they are

2、sometimes called autacoids or local hormones第六頁，共三十一頁。第七頁，共三十一頁。stimulate sensory nerve endings Cause a decrease in systolic and diastolic blood pressure and a increase in heart rate.第八頁，共三十一頁。第九頁，共三十一頁。stimulate sensory nerve endings Cause a decrease in systolic and diastolic blood pressure and a i

3、ncrease in heart rate.第十頁，共三十一頁。 Intradermal injection of histamine causes a characteristic wheal-and-flare response, which involves an erythema, an edematous wheal and a red irregular flare surrounding the wheal.第十一頁，共三十一頁。 To be used in testing gastric acid secretion and diagnosis of leprosy.Decre

4、ase of gastric acid can be seen in malignant anemia and true achlorhydia第十二頁，共三十一頁。Histamine and Antihistamine AgentsHistamine and its agonistsHistamine antagonistsH1 receptor antagonistsH2 receptor antagonists第十三頁，共三十一頁。第十四頁，共三十一頁。Histamine and Antihistamine AgentsHistamine and its agonistsHistamin

5、e antagonistsH1 receptor antagonistsH2 receptor antagonists第十五頁，共三十一頁。First-generation blockersSecond-generation blockers 第十六頁，共三十一頁。urapidly absorbed orallyu widely distributed and the first-generation drugs enter the CNS readily.uMost metabolized in the liver uMost excreted from the kidney第十七頁，共三十

6、一頁。stimulate sensory nerve endings Cause a decrease in systolic and diastolic blood pressure and a increase in heart rate.第十八頁，共三十一頁。第十九頁，共三十一頁。第二十頁，共三十一頁。 Sedation, antimuscarinic action, drug allergy, cardiac arrhythmias (astemizole) and possible teratogenic effects.第二十一頁，共三十一頁。Histamine and Antih

7、istamine AgentsHistamine and its agonistsHistamine antagonistsH1 receptor antagonistsH2 receptor antagonists第二十二頁，共三十一頁。第二十三頁，共三十一頁。stimulate sensory nerve endings Cause a decrease in systolic and diastolic blood pressure and a increase in heart rate.第二十四頁，共三十一頁。第二十五頁，共三十一頁。第二十六頁，共三十一頁。第二十七頁，共三十一頁。第二十八頁，共三十一頁。Gastrointestinal reaction,CNS reaction, Endocrine system reactionCytochrome P-450 inhibition第二十九頁，共三十一頁。第三十頁，共三十一頁。組胺和抗組胺藥內(nèi)容(nirng)總結(jié)組胺(z n)和抗組胺(z n)藥Histamine and Antihistamine Agents。苯海拉明、異丙嗪（非那根）、氯苯那敏（撲爾敏）、布克利嗪（安其敏）。2-(m-F