英文會議演講PPT示例.

1、Effect of Nesiritide in Patients with Acute Decompensated Heart FailurePresented by Dr Wang PUMC OConnor CM, Starling RC, Hernandez AF, Armstrong PW, Dickstein K, Hasselblad V, Heizer GM, Komajda M, Massie BM, McMurray JJ, Nieminen MS, Reist CJ, Rouleau JL, Swedberg K, Adams KF Jr, Anker SD, Atar D,

2、 Battler A, Botero R, Bohidar NR, Butler J, Clausell N, Corbaln R, Costanzo MR, Dahlstrom U, Deckelbaum LI, Diaz R, Dunlap ME, Ezekowitz JA, Feldman D, Felker GM, Fonarow GC, Gennevois D, Gottlieb SS, Hill JA, Hollander JE, Howlett JG, Hudson MP, Kociol RD, Krum H, Laucevicius A, Levy WC, Mndez GF,

3、Metra M, Mittal S, Oh BH, Pereira NL, Ponikowski P, Tang WH, Tanomsup S, Teerlink JR, Triposkiadis F, Troughton RW, Voors AA, Whellan DJ, Zannad F, Califf RM.N Engl J Med. 2011 Jul 7;365(1):32-43 Introduction Treat acute heart faluire Approved in 2001 by FDAOConnor ,N Engl J Med. 2011 Jul 7;365(1):3

4、3 Picture from http:/Controversy Improvement in heart function and relief in difficult breathing Worsen renal function and increase death rateOConnor ,N Engl J Med. 2011 Jul 7;365(1):33 Picture from http:/Effective and safe?Picture from http:/Methods Randomized, double-blind, placebo-controlled tria

5、l From May 2007 through August 2010 at 398 centers Written informed consentOConnor ,N Engl J Med. 2011 Jul 7;365(1):33 Study patientl Key inclusion criteriae.g.,uHospitalized for heart failure within 24 hours uDifficult breathing at restl Key exclusion criteriae.g.,uHigh risk of low blood pressureOC

6、onnor ,N Engl J Med. 2011 Jul 7;365(1):34End Points Change in self-reported dyspnea 6 and 24 hours after study-drug initiation Rehospitalization for heart failure and death from randomization to day 30OConnor ,N Engl J Med. 2011 Jul 7;365(1):34Statistical analysis Estimated in CochranMantel Haenszel

7、(CMH)test P value 0.005OConnor ,N Engl J Med. 2011 Jul 7;365(1):34Results 7141 patients North America, Europe, Latin America, and the AsiaPacific regionOConnor ,N Engl J Med. 2011 Jul 7;365(1):33 Picture from http:/Table 1.Characteristics of PopulationOConnor ,N Engl J Med. 2011 Jul 7;365(1):36,Tabl

8、e 1Figure 1A.Changes in Dyspnea at 6 and 24 Hours OConnor ,N Engl J Med. 2011 Jul 7;365(1):38,Figure 1AFigure 1B.Primary clinical end points at 30 DaysOConnor ,N Engl J Med. 2011 Jul 7;365(1):38,Figure 1BConclusions No improvement in patients with acute heart failure No change in the rate of death and rehospitalization No longer be recommendedOConnor ,N Engl J Med. 2011 Jul 7;365(1):42Limitations Study population Evaluation of dyspnea Lower clinical-event rateO