重組人骨形態(tài)發(fā)生蛋白 4作用機(jī)制 - Medchemexpress - MCE中國(guó)

1、Product Data SheetRecombinant Human Bone Morphogenetic Protein 4Cat. No.: HY-P7007Synonyms: rHuBMP-4; BMP-2BSpecies: HumanSource: E. coliAccession: P12644Gene ID: 652Molecular Weight: Approximately 13.3 kDaPROPERTIESAA SequenceM S P K H H S Q R A R K K N K N C R R H S L Y V D F S D V G WN DW I V A P

2、 P G Y Q A F Y C H G D C P F P L A D H L N S T N H A I V Q T L V N S V N S S I P K A C C V P T E L S A I S M L Y L D E Y D K V V L K N Y Q E M V V E G C G C RAppearance Lyophilized powder.Formulation Lyophilized after extensive dialysis against solution in 50 mM Na2CO3, 5 mM DTT, pH 11.0.Endotoxin L

3、evel 0.2 EU/g, determined by LAL method.Reconsititution Reconstitute the lyophilized recombinant Human Bone Morphogenetic Protein 4 (rHuBMP-4) to 0.1-1.0 mg/mL usingsterile distilled water or aqueous buffer containing 0.1% BSA.Storage & Stability Lyophilized recombinant Human Bone Morphogenetic Prot

4、ein 4 (rHuBMP-4) is stored at -20C. After reconstitution, itis stable at 4C for 1 week or -20C for longer. It is recommended to freeze aliquots at -20C or -80C for extended storage.Shipping Room temperature in continental US; may vary elsewhere.DESCRIPTIONBackground Bone morphogenetic protein-4 (BMP

5、-4) is a member of the BMP-family, a group of growth factors, initiallydiscovered for their ability to initiate bone formation when transplanted to ectopic sites. Bone morphogeneticprotein-4 is part of the transforming growth factor (TGF-) superfamily and is widely expressed from earlyembryogenesis

6、through adulthood. Bone morphogenetic protein-4 also plays a key role in mesenchyme formationand the development of multiple organs. In addition, BMP-4 also functions as a differentiation factor tohematopoietic and nerve cells and promotes epidermal commitment. Mature BMP-4 is a homodimeric glycopro

7、teinwith a cystine knot1.Page 1 of 2 www.MedChemEREFERENCES1. Gieseler GM, et al. Solubilization and renaturation of biologically active human bone morphogenetic protein-4 from inclusion bodies. Biotechnol Rep(Amst). 2018 Apr 4;18:e00249.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3