Isoliquiritigenin-GU17-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIsoliquiritigeninCat. No.: HY-N0102CAS No.: 961-29-5Synonyms: GU17; ISL; Isoliquiritigen分式: CHO分量: 256.25作靶點: Aldose Reductase; Autophagy作通路: Metabolic Enzyme/Protease; Autophagy儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C

2、6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/mL (390.24 mM)Ethanol : 100 mg/mL (390.24 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.9024 mL 19.5122 mL 39.0244 mL5 mM 0.7805 mL 3.9024 mL 7.8049 mL10 mM 0.3902 mL 1.9512 mL 3.9024 mL請根據(jù)

3、產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟?，再依次添加助溶?為保證實驗結果的可靠性，體內實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.76 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (2

4、0% SBE-CD in saline)1/3 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (9.76 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (9.76 mM); Clear solution4. 請依序添加每種溶劑： 10% EtOH 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.76 mM); Clear solutio

5、n5. 請依序添加每種溶劑： 10% EtOH 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (9.76 mM); Clear solution6. 請依序添加每種溶劑： 10% EtOH 90% corn oilSolubility: 2.5 mg/mL (9.76 mM); Suspended solutionBIOLOGICAL ACTIVITY物活性 Isoliquiritigenin從光果草根中分到的黃酮類化合物，具有抗腫瘤的活性，能夠抑制 aldose reductase 的活性，IC50 值為 320 nM。IC50 & Targ

6、et IC50: 320 nM (Aldose reductase)體外研究 Isoliquiritigenin may prevent diabetic complications through inhibiting rat lens aldose reductase with an IC50of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 M 1. Isoliquiritigenin (100M) markedly inhibits the hypoxia-induced pr

7、olonged TPS and TR90 of cardiomyocytes. Isoliquiritigeninsignificantly triggers AMPK Thr172 phosphorylation as compared with vehicle group. Isoliquiritigenintreatment also induces extracellular signal-regulated kinase (ERK) signaling pathway in the cardiomyocytes.Isoliquiritigenin treatment signific

8、antly decreases the intracellular ROS levels of isolated cardiomyocytesduring hypoxia/reoxygenation 3. Isoliquiritigenin not only downregulates IL-6 expression but alsosignificantly decreases levels of phosphorylated ERK and STAT3 and can inhibit phosphorylation levels ofERK and STAT3 induced by rec

9、ombinant human IL-6, which are critical signaling proteins in IL-6 signalingregulation networks 4.體內研究 Isoliquiritigenin shows concentration-dependent inhibition of the tonic contraction of mouse jejunum inducedby various types of stimulants such as CCh (1 mM), KCl (60 mM) and BaCl2 (0.3 mM) with IC

10、50 values of4.961.97 mM, 4.031.34 mM and 3.700.58 mM, respectively 2. Isoliquiritigenin exhibits significant anti-tumor activity in MM xenograft models and synergistically enhances the anti-myeloma activity of adriamycin4.戶使本產品發(fā)表的科研獻 Am J Transl Res. 2018 Dec 15;10(12):4141-4151. Onco Targets Ther.

11、2018 Mar 22;11:1633-1642. Oncol Lett. 2018 Nov;16(5):6133-6139. Chemotherapy. 2018 Jun 22;63(3):155-161. Open Life Sci. 2017; 12: 300307See more customer validations on HYPERLINK / www.MedChemE2/3 Master of Small Molecules 您邊的抑制劑師www.MedChemEREFERENCES1. Aida K, et al. Isoliquiritigenin: a new aldos

12、e reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8.2. Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. BiolPharm Bull. 2007 Jan;30(1):145-9.3. Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway.Mediators Inflamm. 2013;2013:390890.4. Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012Nov;90(11):1311-9.McePdfHe