MMV008138 _Parasite 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMMV008138Cat. No.: HY-123561CAS No.: 1679333-73-3分式: CHClNO分量: 361.22作靶點(diǎn): Parasite作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 125 mg/mL (346.05 mM; Need ultrasonic)Ma

2、ss Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.7684 mL 13.8420 mL 27.6840 mL5 mM 0.5537 mL 2.7684 mL 5.5368 mL10 mM 0.2768 mL 1.3842 mL 2.7684 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬?chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的

3、百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.76 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.76 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 MMV008

4、138種物種選擇性抗瘧劑，靶向 MEP 途徑中的 IspD 酶，對惡性瘧原 Dd2 株作的 IC50 值為 250 nM 1 2。IC50 & Target IC50: 250 nM (P. falciparum Dd2 strain) 1REFERENCES1. Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3

5、S)-MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4(4):549-559.2. Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initialstructure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-