Cinchonidine-α-Quinidine-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECinchonidineCat. No.: HY-N0173CAS No.: 485-71-2Synonyms: -Quinidine分式: CHNO分量: 294.39作靶點(diǎn): Serotonin Transporter作通路: Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 33.33 m

2、g/mL (113.22 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.3969 mL 16.9843 mL 33.9685 mL5 mM 0.6794 mL 3.3969 mL 6.7937 mL10 mM 0.3397 mL 1.6984 mL 3.3969 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您

3、現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.49 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.49 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master

4、of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (8.49 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Cinchonidine (-Quinidine)在雞納和蒿中發(fā)現(xiàn)的雞納物堿。 Cinchonidine (-Quinidine) 于有機(jī)化學(xué)中不對(duì)稱合成的砌塊。 素轉(zhuǎn)運(yùn)蛋 (SERT)的弱抑制劑，對(duì)于dSERT，hSERT，hSERTI172M，hSERT S438T，hSERT Y95F的 Ki 分別為330，4.2，36，196，15 M。有抗瘧活性 1.。IC50 & Ta

5、rget Ki: 330 M (dSERT), 4.2 M (hSERT), 36 M (hSERT I172M), 196 M (hSERT S438T), 15 M (hSERTY95F) 1體外研究 Cinchonidine (-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. Abuilding block used in asymmetric synthesis in organic chemistry. Weak inhibitor of seroto

6、nin transporter(SERT) with Kis of 330, 4.2, 36, 196, 15 M for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERTY95F, respectively 1.REFERENCES1. Beckman ML, et al. Stereoselective inhibition of serotonin transporters by antimalarial compounds. Neurochem Int. 2014 Jul;73:98-106.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400