LY404039 _mGluR 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELY404039Cat. No.: HY-50906CAS No.: 635318-11-5分式: CHNOS分量: 235.21作靶點: mGluR作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 3.84 mg/mL (16.33 mM; Need ultrasonic

2、 and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.2515 mL 21.2576 mL 42.5152 mL5 mM 0.8503 mL 4.2515 mL 8.5030 mL10 mM 0.4252 mL 2.1258 mL 4.2515 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 LY404039是mGluR1和mGluR2的抑制劑，Ki分別為149 nM和92 nM，還能抑制多巴胺受體。REFERENCES1. R

3、orick-Kehn LM, Johnson BG, Burkey JL, Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selectivemetabotropic glutamate 2/3 receptor agonist: in vitro characterizationofagonist(-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo3.1.0-hexane-4,6-dicarboxylic acid (LY404039).

4、J Pharmacol Exp Ther. 2007 Apr;321(1):308-17.2. Seeman P. An agonist at glutamate and dopamine D2 receptors, LY404039. Neuropharmacology. 2013 Mar;66:87-8.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. Rorick-Kehn LM, Johnson BG, Knitowski KM, In vivo pharmacological characterization of the structurally novel, potent, selectivemGlu2/3 receptor agonistLY404039 in animal models of psychiatric disorders. Psychopharmacology (Berl). 2007 Jul;193(1):121-36.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559