Cyclo-RGDyK-trifluoroacetate _Integrin 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECyclo(RGDyK) trifluoroacetateCat. No.: HY-100563CAS No.: 250612-42-1分式: CHFNO分量: 847.72Sequence: ArgGlyAspTyrLysSequence Shortening: RGDYK作靶點(diǎn): Integrin作通路: Cytoskeleton儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-2

2、0C 1 month溶解性數(shù)據(jù)體外實(shí)驗 DMSO : 130 mg/mL (153.35 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.1796 mL 5.8982 mL 11.7963 mL5 mM 0.2359 mL 1.1796 mL 2.3593 mL10 mM 0.1180 mL 0.5898 mL 1.1796 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗請根據(jù)您的實(shí)驗動物和給藥式選

3、擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實(shí)驗結(jié)果的可靠性，體內(nèi)實(shí)驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (2.56 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD

4、 in saline)Solubility: 2.17 mg/mL (2.56 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.17 mg/mL (2.56 mM); Clear solution; Need warmingBIOLOGICAL ACTIVITY物活性 Cyclo(RGDyK) trifluoroacetate種有效的選擇性 V3 整聯(lián)蛋 (integrin) 抑制劑，IC50 為 20 nM。IC50 & Target IC50: 20 nM (V3 Integrin), 3000 nM

5、(IIb3 Integrin), 4000 nM (V5 Integrin) 1體外研究 Cyclo(RGDyK) (c(RGDyK(SAA) shows high affinity and selectivity for V3 over V5 (IC50=4000 nM) andIIb3 (IC50=3000 nM) 1.REFERENCES1. Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics.J Nucl Med. 2001 Feb;42(2):326-36.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0